Cancer Epigenetics

Biomolecular Therapeutics in Human Cancer
1. Auflage 2011
ISBN: 978-0-471-71096-7
Verlag: Wiley

Buch, Englisch, 436 Seiten, Format (B × H): 164 mm x 246 mm, Gewicht: 755 g

The sole resource to focus on cutting-edge biomolecular approaches to cancer therapy

Presenting the latest research in cancer biology, Cancer Epigenetics reveals the most promising developments in novel therapeutics and diagnostic options for cancer patients. Featuring contributions from international authorities in diverse disciplines, the book offers clear therapeutic approaches and applications and facilitates collaboration between the basic, translational, and clinical sciences.

This volume is divided into five sections:

* Epigenetics and cell cycle
* Epigenetics and cell development, senescence and differentiation
* Epigenetics and gene transcription
* Epigenetics and cancer
* Epigenetics and anticancer drug development and therapy

Emphasizing practical applications of research, Cancer Epigenetics provides comprehensive coverage of therapeutic approaches in clinical testing and at the final stages of pre-clinical development. It also discusses new advances in the development of novel therapeutics, including angiogenesis inhibitors and antiretroviral therapies.

Research and clinical oncologists, translational cancer researchers, health professionals dealing with cancer science and therapies, and medical and biomedical science students will rely on this timely and authoritative resource.

Cover Art: The cover image shows an original piece of artwork by a renowned Italian artist Lello Esposito. It depicts nucleotides and a tumor cell, which of course relates directly to the theme of this new book. Mr. Esposito dedicated this piece to the Sbarro Health Research Organization.

Autoren/Hrsg.

Giordano, Antonio

Macaluso, Marcella

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Pharmazie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Onkologie, Krebsforschung
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizin, Gesundheitswesen Biomedizin, Medizinische Forschung, Klinische Studien
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Vorklinische Medizin: Grundlagenfächer Molekulare Medizin, Zellbiologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Pharmakologie, Toxikologie

Inhaltsverzeichnis

Contributors.

Preface.

SECTION I: EPIGENETICS AND CELL CYCLE.

1 Epigenetic Modulation of Cell Cycle: An Overview (Micaela Montanari, Antonio Giordano, Marcella Cintorino, and Marcella Macaluso).

SECTION II: EPIGENETICS AND CELL DEVELOPMENT, SENESCENCE AND DIFFERENTIATION.

2 Epigenetics in Skeletal Muscle Development (Cristina Giacinti and Antonio Giordano).

3 Epigenetic Control in Cellular Senescence (Heike Helmbold, Wolfgang Deppert, and Wolfgang Bohn).

4 Epigenetic Modulation in Cell Development and Differentiation (Mario Mancino, Claudia Esposito, Raffaella Pasquale, Immacolata Vocca, and Francesca Pentimalli).

SECTION III: EPIGENETICS AND GENE TRANSCRIPTION.

5 Epigenetic Control of Gene Transcription (Christian Bronner, Mayada Achour, Thierry Chataigneau,and Valerie B. Schini-Kerth).

6 Epigenetics, MicroRNAs, and Cancer: An Update (Giuseppe Russo, Andrew Puca, Francesco Masulli, Stefano Rovetta,Letizia Cito, Debora Muresu, Flavio Rizzolio, and Antonio Giordano).

SECTION IV: EPIGENETICS AND CANCER.

7 The Role of Epigenetic Modifications in Cancer (Michael J. Powell, Vladimir M. Popov, Xiang Wang, Steven B. McMahon,Alexander Mazo, and Richard G. Pestell).

8 MBD4/MED1 Protein in DNA Repair and Demethylation, Cancer, and Other Diseases (Serena Buontempo, Mara Sannai, and Alfonso Bellacosa).

9 Epigenetics in Pediatric Cancers (Roberta Ciarapica, Lavinia Raimondi, Federica Verginelli, and Rossella Rota).

10 Epigenetic Mechanisms in Cancer Formation and Progression (Elisabetta Fratta, Luca Sigalotti, Alessia Covre, Giulia Parisi, Riccardo Danielli, Hugues Jean Marie Nicolay, Sandra Coral, and Michele Maio).

SECTION V: EPIGENETICS AND ANTICANCER DRUG DEVELOPMENT AND THERAPY.

11 Recent Advances in the Field of Stem Cell Research: Toward the Definition of the Epigenetic and Genetic Codes of Pluripotency (Gaetano Romano).

12 Potential of Heat Shock Protein Targeting for Human Therapy (Laszlo Otvos, Jr).

13 Advances in Stem Cell Therapy for Cancer Research (Andrew Puca and Antonio Giordano).

14 Epigenetic Targets and Drug Development (Paraskevi Vogiatzi, Maria Irene Scarano, and Pier Paolo Claudio).

Index.

Über Autor(innen)

Macaluso, Marcella
Marcella Macaluso, Ph.D., is associate professor of biology and a researcher in the Hormone-Signaling and Cancer Program of the Sbarro Institute for Cancer Research at Temple University in Philadelphia.

Giordano, Antonio
Antonio Giordano, M.D., Ph. D., is professor of biology and medical research at Temple University College of Science and Technology in Philadelphia, Pennsylvania. In 1993 he co-founded the Sbarro Institute for Cancer Research and Molecular Medicine. He has been honored as Knight by the president of Italy and is recipient of the National Italian-American Political Action Committee (NIA-PAC) National Lifetime Achievement Award in Medical Research.

Antonio Giordano, M.D., Ph. D., is professor of biology and medical research at Temple University College of Science and Technology in Philadelphia, Pennsylvania. In 1993 he co-founded the Sbarro Institute for Cancer Research and Molecular Medicine. He has been honored as Knight by the president of Italy and is recipient of the National Italian-American Political Action Committee (NIA-PAC) National Lifetime Achievement Award in Medical Research.

Marcella Macaluso, Ph.D., is associate professor of biology and a researcher in the Hormone-Signaling and Cancer Program of the Sbarro Institute for Cancer Research at Temple University in Philadelphia.