Multicomponent Reactions

Applications in Organic Synthesis and Drug Discovery
1. Auflage 2026
ISBN: 978-3-527-35561-7
Verlag: Wiley-VCH GmbH

Buch, Englisch, 752 Seiten, Format (B × H): 170 mm x 244 mm

Comprehensive coverage of sustainable multicomponent reactions across multiple disciplines
 
Multicomponent reactions enable the combination of three or more starting materials in a single vessel to afford diverse and complex products while aligning with green chemistry principles. This two-volume work summarizes the most recent MCR applications and emerging trends, providing expert knowledge on current advancements across organic chemistry, medicinal chemistry, polymer and analytical chemistry.
 
The book explores sustainable chemical approaches, such as electrochemistry, photochemistry, mechanochemistry, and flow chemistry. It also covers biocatalytic MCRs, reactions in non-conventional solvents, isotope labeling, and late-stage functionalization.
 
Additional topics include:
* Artificial intelligence and automated synthesis (HTS) enhancing MCRs workflows in research laboratories
* Drug discovery applications demonstrating how MCRs rapidly generate diverse chemical libraries of heterocycles and bioactive compounds, including protein degraders
* Reactive intermediates and reaction mechanisms in multicomponent processes
* Innovative approaches for designing advanced materials with specific functional properties
* MCRs in chemical education
 
This comprehensive book will benefit organic chemists, medicinal chemists, materials scientists, and chemical engineers, providing them with practical knowledge of sustainable synthetic methods from expert contributors across various research fields.

Autoren/Hrsg.

Giustiniano, Mariateresa

Fachgebiete

• Naturwissenschaften Chemie Chemie Allgemein Pharmazeutische Chemie, Medizinische Chemie
• Naturwissenschaften Biowissenschaften Biochemie (nichtmedizinisch)
• Technische Wissenschaften Verfahrenstechnik | Chemieingenieurwesen | Biotechnologie Technologie der Kunststoffe und Polymere
• Naturwissenschaften Chemie Organische Chemie

Inhaltsverzeichnis

Preface
 
1. Multicomponent Reactions for a Sustainable Organic Synthesis
2. Light-triggered Multicomponent Reactions
3. Multicomponent Electrochemical Strategies for Modern Organic Synthesis
4. Mechanochemical Multicomponent Reactions
5. The Use of Microwave-assisted Multicomponent Reactions for the Synthesis of Heterocycles Containing Isatin or Organophosphorus Moiety
6. Biocatalytic Multicomponent Reactions
7. Isocyanide-Based Multicomponent Reactions in Aqueous Media
8. Non-Isocyanide-Based Multicomponent Reactions in Aqueous Media
9. The Use of Nonconventional Solvents in Multicomponent Reactions
10. Nanoreactors Technology in Multicomponent Reactions
11. Multicomponent Reactions in Automated Synthetic Chemistry
12. Scale-up and Automation of Multicomponent Reactions via Continuous Flow
13. Investigating Multicomponent Reactions Mechanisms
14. Reactive Intermediates in Isocyanide-based Multicomponent Reactions
15. Heterocycle-based Multicomponent Reactions
16. Multicomponent Synthesis of Functional Chromophores
17. Atropisomers and Molecular Balances via Multicomponent Reactions
18. Multicomponent Synthesis of Organoselenium Compounds
19. Multicomponent Reactions in Isotope Labelling
20. Harnessing Multicomponent Reactions for the Functionalization of Drugs and Bioactive Natural Products via Innate Reactivity
21. Multicomponent Reactions for the Synthesis of Protein Degraders
22. Synthesis of Natural Compounds via Multicomponent Reactions
23. Multicomponent Reactions in the Total Synthesis of Biologically Active Natural Products. Part 1: Reactions Based on the Use of Isocyanides, Transition Metal Catalysis and Tandem Conjugate Addition/Electrophilic Enolate Trapping on alpha,beta-Unsaturated Carbonyls
24. Multicomponent Reactions in the Total Synthesis of Biologically Active Natural Products. Part 2: MCRs Initiated by Nucleophilic Addition to Carbonyl Compounds, Mannich and Related Reactions, Anion Relay Chemistry, [4+2]-Cycloadditions and Other Transformations
25. Multicomponent Reactions in Polymer Chemistry
26. Multicomponent Derivatization for Advanced Gas and Liquid Chromatographic Methods
27. Multicomponent Reactions in Chemical Education

Über Autor(innen)

Mariateresa Giustiniano is an associate professor at the University of Naples Federico II in Italy. She has co-authored over 60 peer-reviewed publications and four book chapters, with research interests spanning multicomponent reactions, visible-light photocatalysis, and their application in medicinal chemistry for discovering new anticancer agents.