Biocatalysis in Asymmetric Synthesis

Erscheinungsjahr 2024
ISBN: 978-0-443-19057-5
Verlag: Elsevier Science

Buch, Englisch, 520 Seiten, Format (B × H): 235 mm x 191 mm, Gewicht: 450 g

Biocatalysis in Asymmetric Synthesis, a new volume in the Foundations and Frontiers of Enzymology series, offers an applied discussion on synthesizing biological catalysts using asymmetric synthesis for varying applications. Here, global experts in the field analyze a wide variety of biocatalysts and their physical states, process conditions for their asymmetric synthesis, solvents required during synthesis, and even downstream procedures for the recovery of final products. The book adopts an interdisciplinary approach, merging fundamental biology and its synthetic applications across industries with a wide range of practical examples, from directed evolution to biotransformation and production of novel enzymes and non-conventional catalysts. Throughout the book, the impact and application of biocatalysis in sustainable processing is considered in-depth. This book will also help non-experts in biocatalysis to apply this knowledge in their own research, providing a thorough overview of the ways asymmetric biocatalytic approaches may be adapted for different disciplines and downstream products.

Autoren/Hrsg.

Gonzalo, Gonzalo De

Alcántara, Andrés R.

Fachgebiete

• Technische Wissenschaften Verfahrenstechnik | Chemieingenieurwesen | Biotechnologie Biotechnologie
• Naturwissenschaften Physik Angewandte Physik Biophysik
• Naturwissenschaften Biowissenschaften Molekularbiologie
• Naturwissenschaften Biowissenschaften Biochemie (nichtmedizinisch)

Inhaltsverzeichnis

List of contributors

About the editors

Preface

1. Introduction to asymmetric synthesis employing biocatalysts

Andrés R. Alcántara and Gonzalo de Gonzalo

1.1 Introduction

1.2 Type of enzymatic processes for generating asymmetry

1.3 Biocatalysts preparations

1.4 Novel-to-nature enzymatic processes

1.5 Enzymes in multicatalytic systems

1.6 Outlook

References

2. Biocatalysis and Green Chemistry: assessing the greenness of enzymatic processes

Andrés R. Alcántara and Pablo Domínguez de María

2.1 Introduction

2.2 Green Chemistry metrics

2.3 Green Chemistry in biocatalysis for practitioners: defining the boundaries of a biocatalytic reaction

2.4 Conclusions

References

3. Study of stereocontrol in enzymatic reactions using atomic models and computational methods

Daniel Platero-Rochart and Pedro A. Sánchez-Murcia

3.1 Introduction

3.2 Relevant features for stereocontrol in enzymes

3.3 Studying the stereocontrol in enzyme catalysis using atomic models

3.4 Some final considerations for a step-by-step protocol for simulation of enzyme activity

References

4. Control of the activity and enantioselectivity in biocatalyzed procedures: immobilization, medium engineering, and protein engineering

Zhongyao Tang, Fahmi Ihza Alghiffary and Tomoko Matsuda

4.1 Introduction

4.2 Immobilization of enzymes

4.3 Medium engineering

4.4 Protein engineering

4.5 Conclusions and future perspectives

References

5. Hydrolases and their application in asymmetric synthesis

Georgina Sandoval

5.1 Hydrolases

5.2 Low/nonaqueous solvents as media for asymmetric synthesis by hydrolases

5.3 Asymmetric synthesis catalyzed by key lipases

5.4 Proteases (peptidases)

5.5 Other hydrolases in asymmetric synthesis

5.6 Tools to discover and improve hydrolases

5.7 Conclusions

References

6. Biocatalysis for the selective reduction of carbonyl groups

Gonzalo de Gonzalo and Antonio Franconetti

6.1 Introduction

6.2 Examples of the application of alcohol dehydrogena

Über Autor(innen)

Alcántara, Andrés R.
Prof. Andrés R. Alcántara is a Full Professor at the Department of Chemistry in Pharmaceutical Sciences of the Pharmacy Faculty at the Complutense University of Madrid, Spain. He obtained his Degree and his Ph. D. in Chemistry at the University of Córdoba (Spain). He spent his postdoctoral stage at the University of Kent Canterbury (UK), returning to the Complutense University where he was Associate Professor from 1993 until 2018, when he gained Full Professorship. His research has been focused on Biotransformations and Applied Biocatalysis in Organic Chemistry, more specifically, in the preparation of enantiomerically pure compounds as chemical drug precursors, using mainly proteases, lipases and alcohol dehydrogenases, either native or immobilized. On the other hand, his work fits perfectly within Sustainable Chemistry, since he has applied these biocatalysts mainly in sustainable bio-solvents, which generates a very beneficial synergy from the point of view of the sustainability of the processes. All this has led him to publish more than 130 scientific papers, reviews, monographs, book chapters, and more than 100 communications to national and international Congresses. He is a member of the Board of ESAB (European Society of Applied Biocatalysis) and ESAB delegate inside the Board of SusChem, the European Platform of Sustainable Chemistry.

Gonzalo, Gonzalo De
Prof. Gonzalo de Gonzalo is an Associate Professor at the Organic Chemistry Department of the Chemistry Faculty at the University of Seville, Spain. He obtained his Degree and his Ph.D. in Chemistry at the University of Oviedo, Spain. He spent his postdoctoral stage at Consiglio Nazionale delle Ricerche, Milan, Italy, moving back to University of Oviedo with a Juan de la Cierva Fellowship. In 2010, he spent one year at the University of Groningen, The Netherlands, working in the research of novel oxidative enzymes. He worked two years for the pharmaceutical company Antibióticos S.A.U. León, Spain, moving to Seville in 2014 as a Ramón y Cajal Researcher, getting his present position in 2019. His research is focused on asymmetric synthesis by using different approaches, including biocatalytic and organocatalytic procedures, as well as the development of concurrent chemo- and biocatalytic reactions. He has published more than 90 scientific papers, including two books focused on biocatalysis applied to the synthesis of valuable compounds.