Buch, Englisch, Band 237, 344 Seiten, Format (B × H): 183 mm x 260 mm, Gewicht: 803 g
Reihe: Neuromethods
Buch, Englisch, Band 237, 344 Seiten, Format (B × H): 183 mm x 260 mm, Gewicht: 803 g
Reihe: Neuromethods
ISBN: 978-1-0716-5467-5
Verlag: Humana
This volume explores the diverse roles that metals play in the brain, including their distribution, regulatory mechanisms, and involvement in disease. The chapters focus on methods to measure neurometals with various technologies and discuss the latest advancements in the field ranging from the molecular underpinnings of metal ion homeostasis and detection to the latest research on how metal dysregulation can lead to brain pathologies. Each chapter covers specific aspects of metal biology in the brain and offers practical insights into the sophisticated methods used to study metal distribution and function. Each chapter also discusses potential therapeutic approaches to modulate metal homeostasis in disease and provides a roadmap for future research and clinical practice. In the
series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory.
Comprehensive and authoritative,
is a valuable resource for both novice and expert researchers, clinicians, and students in the field. This book will inspire further research and discussion on the critical roles that metals play in the brain, fostering a sense of community amongst its readers.
Zielgruppe
Professional/practitioner
Autoren/Hrsg.
Fachgebiete
Weitere Infos & Material
Foundations of Brain Metallomics.- Introduction to Brain Metallomics and Its Relevance to Neuroscience.- Studying Metal Ions in Biology: Some Practical Aspects.- Metal Meets Amyloid: Computational Approaches to Binding, Aggregation, and Neurotoxicity.- Fluorescent Probes for Metal Ion Detection.- Quantification of Metals in Brain Cells and Tissues: Atomic Absorption Spectroscopy (AAS).- Inductively Coupled Plasma Mass Spectrometry in Brain Metallomics.- Detailed Workflow for Cryo-Correlative Light and Synchrotron X-Ray Fluorescence Imaging of Proteins and Metals in Primary Rat Hippocampal Neurons.- Crosstalks between Neurometals and Amyloidogenic Proteins at Synapses and Their Involvement in the Pathogenesis of Neurodegenerative Diseases.- From Cause to Treatment: Brain Metallomics in Neuropsychiatric Disorders.- Brain Metallomics in Neurodevelopmental Disorders: From Pathophysiology to Therapeutics.- Environmental Factors Influencing Brain Metallomics.
