Protein Design

1. Auflage. Softcover version of original hardcover Auflage 2006
ISBN: 978-1-61737-659-7
Verlag: Humana Press

Buch, Englisch, Band 340, 300 Seiten, Previously published in hardcover, Format (B × H): 152 mm x 229 mm, Gewicht: 463 g

Reihe: Methods in Molecular Biology

Protein Design: Methods and Applications presents the most up-to-date protein design and engineering strategies so that readers can undertake their own projects with a maximum chance of success.

The authors present integrated computational approaches that require various degrees of computational complexity, and the major accomplishments that have been achieved in the design and structural characterization of helical peptides and proteins.

Zielgruppe

Research

Autoren/Hrsg.

Guerois, Raphael

de la Paz, Manuela López

Fachgebiete

• Naturwissenschaften Biowissenschaften Biochemie (nichtmedizinisch)
• Naturwissenschaften Biowissenschaften Proteinforschung

Inhaltsverzeichnis

Design of Structural Elementary Motifs.- Structure and Stability of the ?-Helix.- De novo Design of Monomeric ?-Hairpin and ?-Sheet Peptides.- De novo Proteins From Binary-Patterned Combinatorial Libraries.- Non-Protein Amino Acids in the Design of Secondary Structure Scaffolds.- Design and Synthesis of ?-Peptides With Biological Activity.- Design Of Entire Proteins And Protein Complexes.- Design of Miniproteins by the Transfer of Active Sites Onto Small-Size Scaffolds.- Consensus Design as a Tool for Engineering Repeat Proteins.- Multiple Sequence Alignment as a Guideline for Protein Engineering Strategies.- Sequence Search Methods and Scoring Functions for the Design of Protein Structures.- Prediction of Protein–Protein Interaction Based on Structure.- Electrostatic Design of Protein–Protein Association Rates.- Design of Amyloidogenic Polypeptides and Amyloid Inhibitors.- Peptide Model Systems for Amyloid Fiber Formation Design Strategies and Validation Methods.- Protein Misfolding Disorders and Rational Design of Antimisfolding Agents.