Clinical Trials in Neurology

2001. Auflage 2001
ISBN: 978-1-85233-239-6
Verlag: Springer

Buch, Englisch, 542 Seiten, Format (B × H): 186 mm x 265 mm, Gewicht: 1205 g

Clinical Trials in Neurology comprehensively tackles the methodology and design of clinical trials in neurological disease. A general section deals with the ethical aspects, drug development and regulatory requirements, basic trial designs and the statistics used. A diseases section tackles specific aspects of disorders, focusing on the relevant ethical issues, outcome variables and experience with large multicentre trials.

Zielgruppe

Professional/practitioner

Autoren/Hrsg.

Guiloff, Roberto J

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizin, Gesundheitswesen Biomedizin, Medizinische Forschung, Klinische Studien
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizin, Gesundheitswesen Medizinische Ethik
• Geisteswissenschaften Philosophie Angewandte Ethik & Soziale Verantwortung Medizinische Ethik
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Neurologie, Klinische Neurowissenschaft

Inhaltsverzeichnis

1 Ethical Considerations.- 2 Assessment Measures and Clinical Scales.- 3 Ethics, Outcome Variables and Clinical Scales: The Clinician’s Point of View.- 4 The Cochrane Collaboration Reviews in Neurology.- 5 Drug Development Stages.- 6 Drug Regulatory Requirements in the United Kingdom and Europe.- 7 Drug Regulatory Requirements in the United States.- 8 Quality Control and Data Monitoring: A Guide To Good Clinical Practice.- 9 Statistical Issues in Clinical Trials in Neurology.- 10 Analysis of Results: Statistical Principles.- 11 Survival Analysis.- 12 The Intention-to-Treat Principle for Clinical Trials.- 13 Statistical Analysis of Repeated-Measures Data with Drop-outs.- 14 The Role of Meta-analyses in Clinical Research: Uses and Limitations.- 15 Outcome Variables in Dementia Trials: Conceptual and Practical Issues.- 16 Dementia: Trial Design and Experience with Large Multicentre Trials.- 17 Cerebrovascular Disease: Basic Designs, Sample Sizes and Pitfalls.- 18 Clinical Trials in Stroke Prevention in North America.- 19 Cerebrovascular Disease: Experience Within Large Multicentre Trials.- 20 Epilepsy: Ethics, Outcome Variables and Clinical Scales.- 21 Epilepsy: Basic Designs, Sample Sizes and Experience with Large Multicentre Trials.- 22 Headache: Ethics, Outcome Variables and Clinical Studies.- 23 Headache: Basic Trial Designs, Sample Sizes and Pitfalls.- 24 Headache: Experience with Large Multicenter Trials in the Treatment of Migraine Attacks.- 25 Parkinson’s Disease: Outcome Variables and Clinical Scales.- 26 Parkinson’s Disease: A Review of Drug Trials.- 27 Parkinson’s Disease: Experience with Large Multicentre Trials.- 28 Tremor: Clinical Measurement of Impairment, Disability and Handicap.- 29 Tremor: Natural Behaviour, Trial Design and Physiological OutcomeMeasures.- 30 Multiple Sclerosis: Ethics, Outcome Variables and Clinical Scales.- 31 Multiple Sclerosis: Study Design, Sample Sizes and Pitfalls.- 32 Multiple Sclerosis: Experience with Large Clinical Trials.- 33 Motor Neurone Disease: Ethics, Outcome Variables and Clinical Scales.- 34 Motor Neurone Disease: Basic Designs, Sample Sizes and Pitfalls.- 35 Motor Neurone Disease: Experience with Large Multicentre Trials.- 36 Peripheral Neuropathies: Controlled Clinical Trials.- 37 Peripheral Neuropathies: Experience with Large Multicentre Trials.- 38 Disorders of the Neuromuscular Junction: Outcome Measures and Clinical Scales.- 39 Myasthenia Gravis: Basic Designs, Sample Sizes and Pitfalls.- 40 Myopathies: Ethics, Outcome Variables and Clinical Scales.- 41 Myopathies: Basic Designs, Sample Sizes and Pitfalls.