Cellular Senescence and Cardiac Aging

Mechanisms, Therapeutic Strategies, and Implications for Cardiovascular Diseases
Erscheinungsjahr 2026
ISBN: 978-0-443-45811-8
Verlag: Elsevier Science Publishing Co Inc

Buch, Englisch, 344 Seiten, Format (B × H): 216 mm x 276 mm, Gewicht: 450 g

Cellular Senescence and Cardiac Aging: Mechanisms, Therapeutic Strategies, and Implications for Cardiovascular Diseases offers a comprehensive and up-to-date exploration of the molecular and cellular processes driving cardiac aging, with a special focus on cellular senescence. This authoritative volume bridges cutting-edge, basic science with clinical applications, detailing how senescent cells contribute to age-related cardiovascular diseases and highlighting innovative therapeutic approaches such as senolytics and regenerative medicine. Ideal for graduate students, researchers, and clinicians in biomedical sciences, cardiology, pharmacology, and regenerative medicine, this book provides essential insights into biomarkers, epigenetics, autophagy, and emerging treatments.

With contributions from global experts, it also addresses gender and ethnic disparities, ensuring a broad and inclusive perspective. This indispensable resource equips readers with the knowledge needed to advance research and improve patient care in the rapidly evolving field of cardiac aging.

Autoren/Hrsg.

Gupta, Gaurav

Hussain, Md Sadique

Shahwan, Moayad Al

Thapa, Riya

Karmakar, Sanmoy

Fachgebiete

• Naturwissenschaften Biowissenschaften Biowissenschaften

Inhaltsverzeichnis

1. Introduction to Cardiac Aging and Cellular Senescence
2. Molecular Mechanisms of Senescence in Cardiomyocytes
3. Senescence-Associated Secretory Phenotype (SASP) in Cardiac Tissue
4. Mitochondrial Dysfunction, Oxidative Stress, and Cardiac Aging
5. Telomere Attrition and Cardiovascular Senescence
6. Epigenetic Modifications in Cardiac Aging and Senescence
7. Autophagy, Mitophagy, and Senescence in the Heart
8. Senescence-Induced Cardiac Fibrosis and Remodeling
9. Senolytics and Senomorphics: Emerging Therapeutic Strategies
10. Biomarkers of Senescence in Cardiovascular Diseases
11. Regenerative Medicine and Stem Cell Approaches in Cardiac Aging
12. Metabolic Disorders, Obesity, and Accelerated Cardiac Senescence
13. Gender Differences and Ethnic Disparities in Cardiac Aging
14. Clinical Trials and Translational Advances Targeting Cardiac Aging
15. Future Perspectives: Personalized Medicine and Senescence Modulation in Cardiovascular Health

Über Autor(innen)

Thapa, Riya
She is an Assistant Professor at the Uttaranchal Institute of Pharmaceutical Sciences, Uttaranchal University. She holds a Master of Pharmacy in Pharmaceutics and a Bachelor of Pharmacy from Suresh Gyan Vihar University, both awarded with First Class distinction. An emerging voice in pharmaceutical sciences, she has authored over 50 high-impact peer-reviewed articles and several book chapters with renowned publishers such as Elsevier and Springer. Her academic and research pursuits span nanotechnology-based drug delivery, cancer therapeutics, neurodegeneration, and inflammatory diseases. She also serves as an Editor for the Journal of Cancer Therapeutics and Immunotherapy, showcasing her expertise in scientific writing and critical analysis. Riya Thapa’s contribution to academia is further strengthened by active participation in international conferences, workshops, and seminars, reflecting her commitment to continuous learning and collaboration. With a passion for evidence-based research, educational excellence, and innovation, Riya Thapa continues to make meaningful contributions to both scholarly literature and student development, earning respect and admiration among peers and colleagues.

Karmakar, Sanmoy
Is a Professor of Pharmacology & Toxicology, in the Dept of Pharmaceutical Technology at Jadavpur University, Kolkata, India. His research interest involves cardiovascular diseases, bioavailability of drugs and traditional medicine. He also works on toxicity studies on common food and chemical additives. He has established molecular research facilities for receptor specific mRNA studies both in vitro and vivo system. He has to his credit many Government and private funded projects with numerous peer reviewed publications.

Gupta, Gaurav
He is an Adjunct Research Professor at the Centre for Global Health Research at Ajman University, UAE, and the Centre for Research Impact & Outcome at Chitkara College of Pharmacy, Chitkara University, Rajpura. He is a highly accomplished pharmacologist with expertise in cardiovascular diseases, cellular senescence, and molecular mechanisms of cardiac aging. Listed in the World’s Top 2% Scientists (Stanford University, 2020–2024), He has authored over 700 peer-reviewed publications, with a cumulative impact factor exceeding 5000 and more than 20,000 citations. His research focuses on the roles of cellular senescence, oxidative stress, and respiratory diseases. His editorial contributions include Springer volumes on inflammatory lung diseases, epigenetics, and molecular pharmacology.

Hussain, Md Sadique
He is serving as an Assistant Professor at Uttaranchal University. He has completed his Master of Pharmacy (Pharmacology) from Jaipur National University and Bachelor of Pharmacy from Lovely Professional University. He is a prolific and accomplished writer with a diverse portfolio of published works. His impressive body of literature includes >70 peer-reviewed manuscripts, research & review papers, and thought-provoking book chapters. With a passion for knowledge and a keen eye for detail, Md Sadique Hussain researches into various subjects, leaving an indelible mark on academia and beyond. His dedication to crafting insightful content and fostering intellectual curiosity has earned him admiration among peers and readers alike. He continues to contribute to the literary landscape, and his profound impact on the world of writing remains undeniable.

Shahwan, Moayad Al
He is a distinguished Professor of Clinical Biochemistry at the College of Pharmacy and Health Sciences, Ajman University, UAE. With a prolific research career spanning over two decades, he has made significant contributions to biochemistry, pharmaceutical sciences, and health research. Prof. Shahwan earned his Ph.D., M.Sc., and B.Sc. in Biochemistry from Aligarh University, India, between 1994 and 2002. His research portfolio includes 280 peer-reviewed publications, over 40 supervised master’s theses, and multiple research grants, As a dedicated research leader, Prof. Shahwan has played a crucial role in establishing and heading the Centre of Medical and Bio-allied Health Sciences Research. Additionally, he has been a Recipient of Ajman University’s Best Researcher Award (2021 & 2024). Serves on the editorial board of three scientific journals. Principal Investigator (PI) in 15 internal research grants and Co-PI in 9 others. Prof. Shahwan is actively driving strategic research initiatives to strengthen interdisciplinary collaboration, enhance publication impact, and integrate cutting-edge methodologies such as artificial intelligence in research.