Buch, Englisch, Band 137, 290 Seiten, Paperback, Format (B × H): 170 mm x 244 mm, Gewicht: 528 g
Reihe: NATO ASI Series
From Drugs to Proteins
Buch, Englisch, Band 137, 290 Seiten, Paperback, Format (B × H): 170 mm x 244 mm, Gewicht: 528 g
Reihe: NATO ASI Series
ISBN: 978-1-4684-5385-0
Verlag: Springer US
Zielgruppe
Research
Autoren/Hrsg.
Weitere Infos & Material
A) DNA Structure and Interaction with Small Molecules.- DNA structure: Current results from single crystal x-ray diffraction studies.- One- and two- dimensional NMR studies of the structures of simple sequence DNAs.- The major and minor grooves of the DNA helix as conduits for information transfer.- Unusual DNA structures and gene regulation.- Specificity and dynamics of protein — nucleic acid interactions.- DNA and its counterions: metal ions, amino acids, histones and protamines.- Dynamic aspects of antibiotic — DNA interaction.- Specific gene regulation of oligodeoxynucleotides covalently linked to intercalating agents.- Pharmacology of DNA binding drugs.- B) DNA — Protein Interactions: Repressor — Operator Systems.- On the nature and specificity of DNA-protein interactions in the regulation of gene expression.- Searching for the code of ideal protein-DNA recognition.- trp Repressor, a crystallographic study of allostery in genetic regulation.- Structural studies of three DNA binding proteins: catabolite gene activator protein, resolvase and the Klenow fragment of DNA polymerase I.- A two-dimensional NMR study of the complex of lac repressor headpiece with a 14 base pair lac operator fragment.- C) DNA — Protein Interactions: Methylation and Restriction Enzymes.- DNA methylation and mismatch repair: molecular specificities.- Recognition of DNA sequences by restriction endonucleases.- Mechanism and specificity of two restriction enzymes, CauI and CauII, that recognize asymmetrical DNA sequences.- Structure of the DNA-EcoRI endonuclease recognition complex.- D) Outlook: DNA-Protein Interactions of Complex Systems.- Antibodies to nucleic acids.- Summary and Conclusions.- Research Seminars.- Posters.- Participants.