Metal Complex - DNA Interactions

1. Auflage 2009
ISBN: 978-1-4051-7629-3
Verlag: Wiley

Buch, Englisch, 544 Seiten, Format (B × H): 173 mm x 249 mm, Gewicht: 1066 g

Metal ions and metal complexes have long been recognized as critically important components of nucleic acid chemistry, both in regulation of gene expression and as promising therapeutic agents. Understanding how metal complexes interact with DNA has become an active research area at the interface between chemistry, molecular biology and medicine.
Metal Complex - DNA Interactions provides a comprehensive overview of this increasingly diverse field, presenting recent developments and the latest research with particular emphasis on metal-based drugs and metal ion toxicity. The text is divided into four parts:

- Basic Structural and Kinetic Aspects: includes chapters on sequence-selective metal binding to DNA and thermodynamic models. 
- Medical Applications: focuses on anticancer platinum drugs, including discussions on DNA repair in antitumor effects of platinum drugs and photo-dynamic therapy.
- DNA-Recognition - Nucleases and Sensor: describes probes for DNA recognition, artificial restriction agents, metallo-DNAzymes for metal sensing applications and metal ion dependent catalysis in nucleic acid enzymes.
- Toxicological Aspects: deals with structural studies of mercury–DNA interactions, chromium-induced DNA damage and repair, and the effect of arsenic and nickel on DNA integrity.

This book will be a valuable resource for academic researchers and professionals from a range of pharmaceutical and chemical industries, particularly those involved in the development of new and less toxic anticancer metallo-drugs, and in the field of environmental and toxicological chemistry.

Autoren/Hrsg.

Hadjiliadis, Nick

Sletten, Einar

Fachgebiete

• Naturwissenschaften Chemie Chemie Allgemein Chemische Labormethoden, Stöchiometrie
• Naturwissenschaften Chemie Chemie Allgemein Pharmazeutische Chemie, Medizinische Chemie
• Naturwissenschaften Chemie Chemie Allgemein Toxikologie, Gefahrstoffe, Sicherheit in der Chemie
• Naturwissenschaften Chemie Anorganische Chemie Komplexchemie
• Naturwissenschaften Chemie Chemie Allgemein Chemometrik, Chemoinformatik
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Vorklinische Medizin: Grundlagenfächer Physiologie

Inhaltsverzeichnis

A Basic Structural and Kinetic Aspects
1. Sequence-Selective Binding of Transition Metal Complexes to DNA

2. Thermodynamic Models of Metal Ion -DNA.Interactions

3. Metal Ion Coordination in G-quadruplexes

4. Supramolecular Chemistry of Metal-Nucleobase Complexes

B Medical Applications

5. Platinum Drugs, Nucleotides, and DNA: the Role of Interligand Interactions,

nucleotides and DNA

6. Role of DNA Repair in Antitumor Effects of Platinum Drugs

7. Telomeres and Telomerase: Potential Targets for Platinum Complexes

8. Toward Photodynamic Therapy of Cancer with Platinum Group Metal Polyazine Complexes

9. Platinated Oligonucleotides: Synthesis and Applications for the Control of Gene

Expression

10. New Titanium and Ruthenium Anticancer Drugs and their Interaction with DNA

C DNA-Recognition - Nucleases and Sensors

11. Groove-Binding Ruthenium(II) Complexes as Probes of DNA Recognition

12. DNA Recognition and Binding by Peptide-Metal Complex conjugate

13. Artificial Restriction Agents - Hydrolytic Agents for DNA Cleavage

14. New Metallo-DNAzymes: Fundamental Studies of Metal-DNA Interactions and

Metal Sensing Applications

15. Two-metal Ion Dependent Catalysis in Nucleic Acid Enzymes

D Toxicological aspects

16. Mercury- DNA Interactions. Structural Studies on MercuryII -Mediated T-T Base-Pair with NMR Spectroscopy

17. Chromium-Induced DNA Damage and Repair

18. Arsenic and nickel: Mechanisms Affecting DNA Integrity

Über Autor(innen)

Nikolaos Hadjiliadis is Professor in the Dept of Chemistry at the University of Ioannina, Greece. Einar Sletten is Professor in the Dept of Chemistry at the University of Bergen, Norway.