Buch, Englisch, Band Volume 25, 500 Seiten, Format (B × H): 156 mm x 234 mm, Gewicht: 912 g
Reihe: Chemoenzymatic Synthesis of Natural Products and Complex Small Molecules
Buch, Englisch, Band Volume 25, 500 Seiten, Format (B × H): 156 mm x 234 mm, Gewicht: 912 g
Reihe: Chemoenzymatic Synthesis of Natural Products and Complex Small Molecules
ISBN: 978-1-83767-251-6
Verlag: Royal Society of Chemistry
The total synthesis of structurally complex natural products has challenged and inspired generations of chemists. However, despite their history as privileged bioactivity-rich scaffolds, the use of natural products in drug discovery has waned.
Recent developments in biocatalysis have resulted in the application of enzymes for the construction of complex molecules. This dynamically developing field is increasingly becoming a competitive alternative for classical total synthesis. Giving readers an in-depth overview of the current state of the field, this book will be of wide interest to natural products and drug researchers with a chemical or biochemical background and biocatalysis experts in academia and industry.
Chapters include emerging enzymes from biosynthetic pathways, enzymes for building block synthesis and late-stage derivatisation as well as the formation of specific structural elements, such as chiral amines and heterocycles. Other important aspects for the efficient chemoenzymatic synthesis of bioactive molecules include the development of multi-enzyme cascades, engineered enzymes and strategic considerations for the use of biocatalysts in the synthesis of natural products and synthetic drugs.
Autoren/Hrsg.
Fachgebiete
Weitere Infos & Material
- Enzymes in the Synthesis of Natural Products and Other Small Molecules
- The Use of Enzymes Invites a Rethinking of Synthesis: A General Perspective with Special Focus on Enzymatic C–C Couplings
- Chemoenzymatic Synthesis of Terpenoids
- Biocatalytic Production of Nucleotides
- Preparation of Bioactive Compounds via C–N Bond Formation Catalysed by Redox Enzymes
- Biocatalytic Ring Formation in Chemoenzymatic Synthesis
- Side Chain Crosslinking in the Chemoenzymatic Synthesis of NRPS and RiPP Peptide Natural Products
- Biocatalytic Oxidative Dearomatisation
- The Use of Enzymatically-derived cis-1,2-Dihydrocatechols as Starting Points in the Chemical Synthesis of
- Natural Products and Other Biologically Active Compounds
- Halogenating Enzymes in Chemoenzymatic Synthesis
- Enzymatic Synthesis of Glycoconjugates
- Recent Advances in Chemoenzymatic Synthesis with Soluble Microbial Prenyltransferases
- Multi-step Enzyme Cascades for the Synthesis of Natural Products and Active Pharmaceutical Ingredients
