Handbook of Stem Cell Applications

2024
ISBN: 978-981-99-7118-3
Verlag: Springer

Buch, Englisch, 1417 Seiten, Format (B × H): 160 mm x 241 mm, Gewicht: 2812 g

This handbook reviews the clinical applications of stem cell-based therapy. The book covers the clinical applications of stem cells in cardiovascular diseases, neurological and ocular diseases, pediatrics, and the role of cancer stem cell-derived exosomal microRNA payload in lung cancer. The chapter reviews emerging stem cell therapy and tissue engineering approaches in neurodegenerative diseases. The book further examines the applications of stem cells in various fields of dentistry, and for the regeneration of oral and non-oral tissues. The chapters also explore the application of 3D bioprinting in conjunction with bone marrow mesenchymal stem cells for the treatment of bone defects and state-of-the-art technology for bone and cartilage regeneration using mesenchymal stem cells. The book presents stem cell-based therapy against renal, pancreatic, and kidney diseases and examines the advantages of a novel hepatic stem for cirrhotic liver repair and regeneration. Lastly, the book provides methodological and procedural advancements in stem cell-based therapy, including the applications of single-cell sequencing in stem cell research. This handbook is a major one-stop reference for researchers working in regenerative medicine, cellular pharmacology, stem cell research in general, and those involved in specific areas of adult stem cells as well as embryonic and induced pluripotent stem cells.

Zielgruppe

Research

Autoren/Hrsg.

Haider, Khawaja H.

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Neurologie, Klinische Neurowissenschaft
• Naturwissenschaften Biowissenschaften Zellbiologie
• Interdisziplinäres Wissenschaften Wissenschaften Interdisziplinär Neurowissenschaften, Kognitionswissenschaft

Inhaltsverzeichnis

Chapter 1_  The application of stem cells for the therapy of Parkinson’s disease.- Chapter 2_ Stem cell therapy after neurological injuries.- Chapter 3_ Strategies of Stem cell therapy in nervous system injuries repair and regeneration.- Chapter 4_ Neural regeneration therapies for Alzheimer's and Parkinson's disease-related disorders.- Chapter 5_ Emerging Stem Cell Therapy and Tissue Engineering Approaches in Neurodegenerative Diseases.- Chapter 6_ Next Generation of Science with Stem Cell-based Neural Organoids.- Chapter 7_ Mesenchymal stem cells for ocular disorders.- Chapter 8_ Keratocytes evolution in advanced regenerative corneal therapy with keratoconus.- Chapter 9_ Latest advances in mesenchymal stem cell-based therapy of eye diseases.- Chapter 10_ Stem cells in ophthalmology: from the bench to the bedside.- Chapter 11_ Stem cells in periodontal regeneration.- Chapter 12_ Dental pulp stem cells in Endodontics – Advances, applications and challenges.- Chapter 13_ Significance of inflammatory milieu during regeneration of periodontal tissues using dental mesenchymal stem cell.- Chapter 14_ 3D bioprinting in conjunction with bone marrow mesenchymal stem cells for the treatment of bone defects.- Chapter 15_ Allogenic Stem Cells: Advances in Knee Osteoarthritis.- Chapter 16_ Mesenchymal stem cells for bone and cartilage regeneration: state-of-the-art.- Chapter 17_ Clinical trials of cell therapy in muscular dystrophies.- Chapter 18_ Scaling Stem Cells to Cure Millions of Patients with Diabetes – Approaches, Technology, and Future Directions.- Chapter 19_ Restoring ß-cells population through in situ differentiation of the resident pancreatic cells.- Chapter 20_ Stem Cell-Based Regenerative Therapies for Functional Endocrine System Organs: Tissue Engineering Applications and Future Strategies.- Chapter 21_ Recent advance in regenerativemedicine of the liver and bile duct system by chemically induced liver progenitor cells (CLiPs).- Chapter 22_ Advantages of a novel hepatic stem/progenitor cell population for fibrotic/cirrhotic liver repair and regeneration.- Chapter 23_  Evolving Understanding of Renal Progenitor (Stem) Cells in Renal Physiology and Pathophysiology.- Chapter 24_ The regenerative potential of human adult renal stem/progenitor cells.- Chapter 25_ Role of Exosomes as a biomarker in cardio-metabolic and renal diseases.- Chapter 26_ Renovascular applications of stem cells.- Chapter 27_ Reversing the aged Immune system with Stem cells.- Chapter 28_ Germline stem cell technology in fertility preservation.- Chapter 29_ One-stop shop for salivary gland regeneration and other exocrine organs.- Chapter 30_  Epithelial Stem Cell for Regeneration in Acute and Chronic Airway Injury.- Chapter 31_ Genetic Cell Therapy in Anti-Aging Regenerative Cosmetology.- Chapter 32_ Polytrauma and Stem Cells.- Chapter 33_ The Multifaceted Role of Induced Pluripotent Stem Cells in Pre-Clinical Cardiac Regeneration Research.- Chapter 34_ Stem cell-based regenerative medicine therapy in cancer.- Chapter 35_ Novel Prognostic and Predictive Biomarkers in Oncology.- Chapter 36_ Mesenchymal stem cells, cancer stem cells (CSCs), and circulating tumor cells (CTCs): roles and combinations in tumor growth and dissemination.- Chapter 37_ Participation of mesenchymal stem cell in the tumor process.- Chapter 38_ Pre-enrichment of Adipose Tissue Grafts with Adipose Derived Stem Cells: Potential and Limitations.- Chapter 39_ Matrix mechanical cues affect cell behavior and tissue regeneration.- Chapter 40_ Biophysical regulators of mesenchymal stem cell fate.- Chapter 41_ Influence of microbiota of donors and recipients in mesenchymal stem cell behavior regarding epigenetic pattern, stemness and secretome.- Chapter 42_ Mesenchymal stem cells as modern off-the-shelf products: From research perspectives to clinical practice.- Chapter 43_ Application of single-cell sequencing on stem cell research.- Chapter 44_ Proteomics investigations on stem cell-based regenerative medicine.- Chapter 45_ Phospholipid metabolism in stem cells and its application to pathological analysis.- Chapter 46_ The role of stem cells in exercise enhanced organogenesis and regeneration.- Chapter 47_ Mesenchymal stem cell-derived exosomes: A novel remedy for the treatment of Parkinson’s Disease.- Chapter 48_ Time of cell injection.- Chapter 49_Novel Preconditioning approach to promote donor cell survival.

Über Autor(innen)

Dr. Khawaja Husnain Haider is a Professor of Cellular and Molecular Pharmacology (Stem Cell and Gene Therapy) and Chairman of the Basic Sciences Department (Medical Program) at Sulaiman AlRajhi University. Before his current assignment, he served in several prestigious institutions in various parts of the world. He has also served as Principal Investigator (PI) and Co-PI on multiple National Institute of Health (NIH) funded stem cell research projects. He has been on the editorial boards and invited reviewer panels for several respected international journals. His research focuses on using, either alone or in combination, DNA, miRNAs, and stem cells as “drugs,” a topic that has gained popularity in regenerative medicine. He has extensively published in cellular and sub-cellular preconditioning of stem cells besides using their conditioned media for cell-free therapy. He has published nearly 325 book chapters, abstracts, and research papers in various books and leading research journals, including Circulation, Circulation Research, Cardiovascular Research, JCMM, the Journal of Biological Chemistry, Cell Cycle, Basic Research in Cardiology, and Antioxidant Redox Signaling. He has also given numerous presentations and edited ten books covering various facets of stem cells and their applications from drug to drug development.