Extracellular Matrix Remodeling and Deposition in Disease

Erscheinungsjahr 2026
ISBN: 978-3-032-32521-1
Verlag: Springer

Buch, Englisch, 274 Seiten, Format (B × H): 155 mm x 235 mm

Reihe: Biology of Extracellular Matrix

This book explores the fundamental importance of Extracellular Matrix (ECM) remodeling and deposition in health and disease. By understanding the intricate roles of ECM proteins and remodeling enzymes in mediating pathophysiological processes, it is possible to link the molecular mechanics of the ECM across various organs and tissues. This knowledge is essential for developing new therapeutic strategies for diseases linked to abnormal ECM remodeling and deposition.

Key topics discussed include the ECM's interaction with the immune system and resident cells that lead to tissue fibrosis, malignant growth, and musculoskeletal pathology. The book emphasizes the advantages of using big data and systems biology approaches in understanding the diverse roles and properties of ECM remodeling.The contributors are leading authors in the field of matrix biology who created a paradigm-shift in experimental designs enabling linking molecular detail and system biology of pathophysiological ECM remodeling, synthesis and deposition with significant impact on basic and clinical research.

The book is ideal for researchers, scholars and practitioners in the fields of matrix biology, immunology and pathology. It provides valuable insights into the ECM's role in disease onset and progression, paving the way for innovative treatments and interventions.

Zielgruppe

Research

Autoren/Hrsg.

Hasson, Peleg

Sagi, Irit

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Vorklinische Medizin: Grundlagenfächer Anatomie
• Naturwissenschaften Biowissenschaften Zellbiologie
• Naturwissenschaften Biowissenschaften Chemische Biologie, Synthetische Biologie

Inhaltsverzeichnis

MT1-MMP: The cell surface collagen-degrading enzyme.- The protease network as a regulator of extracellular matrix homeostasis and inflammatory skin disease.- The involvement of Lysyl Oxidase in the pathogenesis of Atherosclerosis, Autoimmune diseases, and Cancer.- Lysyl oxidases: a focus on their substrates, expression and regulation in cardiovascular diseases.- Cardiovascular Defects in Connective Tissue Disorders.- The extracellular matrix of skeletal muscle: much more than just cement.- ECM Regulation of Muscle Stem Cells in Health and Dystrophic Muscles.- The Extracellular Matrix and Cancer Progression: A Complex Network Driving Tumor Dynamics.- Harnessing advances in proteomics to gain novel insights into extracellular matrix remodeling in inflammation.

Über Autor(innen)

Prof. Peleg Hasson works in the Department of Genetics and Developmental Biology and heads the Tissue Development laboratory at the Ruth and Bruce Rappaport Faculty of Medicine at the Technion-Israel Institute of Technology. His research looks at the crosstalk between the cell and the extracellular matrix. Focusing on this interplay in skeletal muscle development, he has recently ventured into studying these interactions in other types of muscles, namely the heart and smooth muscle cells. Using novel transgenic lines enabling the modulation of members of the Lysyl oxidase family, he has demonstrated the autonomous roles these secreted enzymes play. Taking advantage of the studies learnt from basic research, his work now also focuses on identifying novel routes to inhibit fibrosis.

Prof. Irit Sagi works in the Department of Immunology & Regenerative Biology, the Weizmann Institute of Science. She is developing and applying unique, multidisciplinary and biophysical approaches to investigate tissue and extracellular remodeling molecular processes. She pioneered innovative methodologies that significantly advanced the understanding of ECM remodeling mediated by key enzymes, like matrix metalloproteinases (MMPs), a disintegrin and metalloproteinases (ADAMs), and lysyl oxidases (LOXs). Her research on MMPs has overcome the longstanding challenge of designing highly selective inhibitors, which has revolutionized the ability to modulate MMPs/ADAMs activity in vivo with unprecedented precision. In recent years, she has utilized these biological inhibitors in conjunction with advanced OMICs technologies, including genomics, proteomics, and metabolomics, to map the cellular and molecular pathways involved in ECM remodeling. These integrative approaches allow to explore ECM enzyme remodeling processes at both the single-cell and tissue levels and provide a holistic view of how ECM dynamics influences cellular behavior and tissue architecture.