Buch, Englisch
Reihe: Translational Oncology
Bridge the gap between laboratory discovery and cancer care and control
While molecular understanding of cancer has expanded exponentially, clinical progress has been more gradual. Introduction to Translational Cancer Research provides a primer for new investigators that focuses on accelerating progress in cancer care, detection and control. Written by physician-scientists with combined expertise spanning biomarker discovery, drug development, and cancer prevention, this volume describes the bidirectional flow between laboratory discoveries and clinical and community applications.
The book examines how human cancer biology and molecular diagnostics have driven the development of molecular therapeutics, leading to personalized treatment, detection and prevention. Translation across the full spectrum of cancer management is described including medical, surgical, radiation and pediatric oncology as well as cancer imaging. Coverage spans drug and biologics development and the application of AI to accelerate the delivery of new agents with greater efficiency. The inter-related roles of academe, pharma and government are considered.
Readers will also find: - How our deepening understanding of cancer biology and immunology have informed the development and use of targeted drugs and biologics, individually and in combination.
- Career development of physician-scientist and members of translational teams
- Research on dissemination of new ideas and agents
- Impact of translational research on underserved patients
- Ways to accelerate progress in cancer research.
Clinical and research oncologists, medical students, graduate students and fellows, biomedical scientists, and pharmaceutical professionals will find this a valuable guide for understanding how translational research transforms laboratory discoveries into improved patient and population-level outcomes.
Autoren/Hrsg.
Weitere Infos & Material
Chapter 1: The Challenge of Translational Cancer Research
Robert C. Bast, Jr., M.D.
Chapter 2: Targets for Translation: Cancer Biology and Tumor Heterogeneity
Robert C. Bast, Jr., M.D.
Chapter 3: Targets for Translation: Tumor Microenvironment and Immunity
Mason Ruiz, Ph.D., Zhiqiang An, Ph.D. Anil K. Sood. M.D
Chapter 4: Molecular Diagnostics
Robert C. Bast, Jr., M.D.
Chapter 5: Drug and Biologics Development Robert C. Bast, Jr., M.D.
Chapter 6: Artificial Intelligence and Data Science to Accelerate Drug Development
Kaitlyn P Russell, Ph.D. and Bissan Al-Lazikani, Ph.D.
Chapter 7: Molecular Therapeutics
Robert C. Bast, Jr., M.D.
Chapter 8: The Personalization of Cancer Care: Linking Molecular Diagnostics and
Molecular Therapeutics
Robert C. Bast, Jr., M.D.
Chapter 9: Cancer Prevention
Ernest Hawk, M.D.
Chapter 10: Multidisciplinary Translational Cancer Research
Maurie Markman, M.D., Mike White, M.D., Vincent Pagan, M.D., Chad Tang, M.D., and Jonathan Gill, M.D.
Chapter 11: Oncologic Imaging Vikas Kundra, M.D., Ph.D.
Chapter 12: Training, Assembling and Sustaining Teams for Translational Cancer Research Robert C. Bast, Jr., M.D.
Chapter 13: Infrastructure for Translational Cancer Research Robert C. Bast, Jr, M.D. Chapter 14: The Role of Government in Translational Cancer Research Ernest Hawk, M.D.
Chapter 15: The Role of the FDA in Translational Cancer Research
Maurie Markman, M.D.
Chapter 16: The Role of Pharma and Biotech in Translational Cancer Research Robert C. Bast, Jr., M.D.
Chapter 17: Funding Translational Research
Robert C. Bast, Jr., M.D.
Chapter 18: The Role of the Community in Translational Cancer Research
Robert C. Bast, Jr., M.D.
Chapter 19: Dissemination and Implementation of Translational Cancer Research
Maria E. Fernandez, PhD and Mary-Louise E. Millett, MPH
Chapter 20: Overcoming Cancer Disparities to Achieve Equity through Translational Cancer Research
Inimfon N. Jackson M.D., M.P.H., Ph.D. Christopher R. Flowers, M.D., M.S. and Chijioke C Nze, M.D., M.P.H.
Chapter 21: Accelerating Translational Cancer Research
Robert C, Bast, Jr., M.D.
