Sequence Variation, Genealogies and Evolution

Erscheinungsjahr 2004
ISBN: 978-0-19-852995-8
Verlag: Oxford University Press

Buch, Englisch, 296 Seiten, Format (B × H): 171 mm x 246 mm

Key Features:- Covers the growing crossover field of Mathematics and Biological Science.
- Practical and Accessible introduction to Coalescent theory
Description:

Coalescent theory tells us what gene genealogies are expected to look like if populations have different demographic histories - i.e., population size, structure, etc. The aim of this book is to provide an accessible introduction to Coalescent Theory with a view towards data analysis. Coalescent Theory has in the last two decades moved from being an obscure technique that appealed to mathematical population geneticists to a central tool in data analysis of DNA sequences. The completion of the sequencing of the human genome and accompanying determination of SNPs and haplotypes will increase its importance even further. This textbook, rich in examples and illustrations, is suitable for a graduate course in statistics, population-, molecular-, and medical-genetics.
Contents:

Preface; Genealogical Approach to Data Analysis; Extensions to the basic coalescent; Coalescent and Recombination; Models of Substitution; Inference under the Coalescent; Frontiers; WWW tools

Zielgruppe

Graduate students in statistics, biosciences and medicine

Autoren/Hrsg.

Hein, Jotun

Schierup, Mikkel

Wiuf, Carsten

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Vorklinische Medizin: Grundlagenfächer Humangenetik
• Naturwissenschaften Biowissenschaften Biowissenschaften Evolutionsbiologie
• Naturwissenschaften Biowissenschaften Molekularbiologie

Über Autor(innen)

JOTUN HEIN, University of Oxford, UK, MIKKEL SCHIERUP, University of Aarhus, Denmark, CARSTEN WIUF, University of Aarhus, Denmark