Animal Experimentation: Working Towards a Paradigm Change

Erscheinungsjahr 2019
ISBN: 978-90-04-35618-4
Verlag: Brill

Buch, Englisch, Band 22, 714 Seiten, Format (B × H): 160 mm x 239 mm, Gewicht: 1179 g

Reihe: Human-Animal Studies

Animal experimentation has been one of the most controversial areas of animal use, mainly due to the intentional harms inflicted upon animals for the sake of hoped-for benefits in humans. Despite this rationale for continued animal experimentation, shortcomings of this practice have become increasingly more apparent and well-documented. However, these limitations are not yet widely known or appreciated, and there is a danger that they may simply be ignored. The 51 experts who have contributed to Animal Experimentation: Working Towards a Paradigm Change critically review current animal use in science, present new and innovative non-animal approaches to address urgent scientific questions, and offer a roadmap towards an animal-free world of science.

Autoren/Hrsg.

Herrmann, Kathrin

Jayne, Kimberley

Fachgebiete

• Naturwissenschaften Biowissenschaften Biowissenschaften Bioethik, Tierethik
• Geisteswissenschaften Philosophie Angewandte Ethik & Soziale Verantwortung Bioethik, Tierethik
• Geisteswissenschaften Philosophie Wissenschaftstheorie, Wissenschaftsphilosophie
• Geisteswissenschaften Philosophie Angewandte Ethik & Soziale Verantwortung Wissenschaftsethik, Technikethik
• Geisteswissenschaften Philosophie Ethik, Moralphilosophie
• Sozialwissenschaften Soziologie | Soziale Arbeit Spezielle Soziologie Wissenssoziologie, Wissenschaftssoziologie, Techniksoziologie

Inhaltsverzeichnis

Foreword

Peter Singer

Preface

Kathrin Herrmann and Kimberley Jayne

Acknowledgement

Notes on Contributors

Introduction

Kathrin Herrmann and Kimberley Jayne

Part 1: Why and How to Shift the Paradigm

1 Refinement on the Way Towards Replacement: Are We Doing What We Can?

Kathrin Herrmann

2 How to Evaluate the Science of Non-human Animal Use in Biomedical Research and Testing: A Proposed Format for Debate

Ray Greek and Lisa A. Kramer

3 How Can the Final Goal of Completely Replacing Animal Procedures Successfully be Achieved?

Christiane Baumgartl-Simons and Christiane Hohensee

4 Disease Prevention with a Plant-based Lifestyle

Sabina Vyas

Part 2: Politics and Legislation of Animal Experimentation

5 Political Campaigning: Where Scientific and Ethical Arguments Meet Public Policy

Emily McIvor

6 Rethinking the 3Rs: From Whitewashing to Rights

Charlotte E. Blattner

7 Contesting Animal Experiments through Ethics and Epistemology: In Defense of a Political Critique of Animal Experimentation

Arianna Ferrari

Part 3: Openness in Animal Experimentation

8 The Moral Status of Animal Research Subjects in Industry: A Stakeholder Analysis

Sarah Kenehan

9 Increasing the Transparency of Animal Experimentation: An Australian Perspective

Monika Merkes and Rob Buttrose

10 Wasted Money in United States Biomedical and Agricultural Animal Research

Jim Keen

Part 4: The Ethics and Philosophy of Animal Experimentation

11 Ethics, Efficacy, and Decision-making in Animal Research

Lawrence A. Hansen and Kori Ann Kosberg

12 Beyond Plausibility Checks: A Case for Moral Doubt in Review Processes of Animal Experimentation

Mara-Daria Cojocaru and Philipp von Gall

13 Human Wrongs in Animal Research: A Focus on Moral Injury and Reification

Jane Johnson and Anna Smajdor

Part 5: Effectiveness of the Animal Model

14 Critically Evaluating Animal Research

Andrew Knight

15 Extrapolation of Animal Research Data to Humans: An Analysis of the Evidence

Rebecca Ram

16 Is Animal-based Biomedical Research being Used in Its Original Context?

Constança Carvalho, Daniel Alves, Andrew Knight and Luis Vicente

17 The Scientific Problems with Using Non-human Animals to Predict Human Response to Drugs and Disease

Ray Greek and Lisa A. Kramer

18 Replacing Animal Tests to Improve Safety for Humans

Kathy Archibald, Robert Coleman and Tamara Drake

19 Genetic Modification of Animals: Scientific and Ethical Issues

Jarrod Bailey

20 Animal Research for Alzheimer Disease: Failures of Science and Ethics

John J. Pippin, Sarah E. Cavanaugh and Francesca Pistollato

21 Behavioral Research on Captive Animals: Scientific and Ethical Concerns

Kimberley Jayne and Adam See

Part 6: Animal-free Education and Training

22 Modernizing Biomedical Training: Replacing Live Animal Laboratories with Human Simulation

John Pawlowski, David Feinstein, Marie L. Crandall and Shalin Gala

23 Humane Education: The Tool for Scientific Revolution in Brazil

Vanessa Carli Bones, Rita de Cassia Maria Garcia, Gutemberg Gomes Alves, Rita Leal Paixão, Alexandro Aluísio Rocha, Karynn Capilé and Róber Bachinski

Part 7: The Paradigm Shift: Advanced Animal-free Approaches

24 Recent Developments in Alternatives to Animal Testing

Katy Taylor

25 The Changing Paradigm in Preclinical Toxicology: in vitro and in silico Methods in Liver Toxicity Evaluations

Fozia Noor

26 The Potential of Organ on Chip Technology for Replacing Animal Testing

Malcolm Wilkinson

27 When is an Alternative Not an Alternative? Supporting Progress for Absolute Replacement of Animals in Science

Craig Redmond

28 Research and Testing Without Animals: Where are We Now and Where are We Heading?

Thomas Hartung

Afterword: Evidence Over Interests

John P. Gluck

Index

Über Autor(innen)

Kathrin Herrmann is a veterinarian and expert for animal welfare science, ethics and law with focus on the 3Rs of animal experimentation. She currently works for the Center for Alternatives to Animal Testing (CAAT) at Johns Hopkins University, MD, USA.

Kimberley Jayne, PhD, has over a decade of research and educator experience working to enhance the welfare of animals in laboratory and entertainment environments. She now works in animal protection, using her experience to end the use of animals in these industries.