Histone Deacetylases in Neurodegenerative Disease Part A

Erscheinungsjahr 2026
ISBN: 978-0-443-47332-6
Verlag: Elsevier Science & Technology

Buch, Englisch, Format (B × H): 152 mm x 229 mm

Histone Deacetylases in Neurodegenerative Disease, Part A, Volume 733 in the Methods in Enzymology series, highlights new advances, with this volume presenting chapters on topics such as HDAC Inhibitor-Induced Endoplasmic Reticulum (ER) Stress, Specific activation of p300/CBP Lysine acetyltransferases induces adult neurogenesis and synaptic plasticity, Chromatin immunoprecipitation assay for analyzing histone H3-mediated regulation of copper homeostasis, Histone Deacetylase 6 modulates Tau structure and function, Histone Acetylation in Parkinson Disease, DNA methylation and histone modification in hypoxic conditions, The extracellular Histone Deacetylase 6 modulates the actin networks in neuronal cells, Epigenetic modulators as therapeutics for neurodegenerative disorder/Alzheimer's disease, and much more.

Additional chapters explore Sirtunins in mitochondrial physiology and energy homeostasis, Sirtunins in metabolic homeostasis, Conformational flexibility of histone variant CENP-ACse4 is regulated by histone H4: A mechanism to stabilize soluble Cse4, Analysis of copper toxicity by western blotting of secretory proteins translocated via Sec61 channel, Histone deacetylase as a potential therapeutic target for memory disorders, Histone deacetylases in Neurodegeneration, Role of Deubiquitinases in Regulating Tau Acetylation and Autophagic Clearance in Alzheimer’s Disease, Histone deacetylases in Neurodegeneration and neuronal plasticity, and more.

Autoren/Hrsg.

Weitere Mitwirkende

Christianson, David

Allen, Karen N.

Chinnathambi, Subashchandrabose

Fachgebiete

• Naturwissenschaften Biowissenschaften Biochemie (nichtmedizinisch)
• Naturwissenschaften Biowissenschaften Molekularbiologie
• Naturwissenschaften Physik Angewandte Physik Biophysik

Inhaltsverzeichnis

1. HDAC Inhibitor-Induced Endoplasmic Reticulum (ER) Stress
Christian Marx
2. Specific activation of p300/CBP Lysine acetyltransferases induces adult neurogenesis and synaptic plasticity
Tapas K. Kundu
3. Chromatin immunoprecipitation assay for analyzing histone H3-mediated regulation of copper homeostasis
Raghuvir Singh Tomar, Rakesh Kumar Sahu and Sakshi Singh
4. Histone Deacetylase 6 modulates Tau structure and function
Subashchandrabose Chinnathambi
5. Histone Acetylation in Parkinson Disease
Zhuohua Zhang
6. DNA methylation and histone modification in hypoxic conditions
Sanjeev Shukla
7. The extracellular Histone Deacetylase 6 modulates the actin networks in neuronal cells
Subashchandrabose Chinnathambi
8. Epigenetic modulators as therapeutics for neurodegenerative disorder/Alzheimers disease
Balaram Ghosh
9. Sirtunins in mitochondrial physiology and energy homeostasis
Ullas Kothur-Seetharam
10. Sirtunins in metabolic homestasis
Nagalingam Ravi Sundaresan
11. Conformational flexibility of histone variant CENP-ACse4 is regulated by histone H4: A mechanism to stabilize soluble Cse4
Ashutosh Kumar
12. Analysis of copper toxicity by western blotting of secretory proteins translocated via Sec61 channel
Raghuvir Singh Tomar, Smriti Anand, Prateeksha Thakur, Vandana Anjana, Santoshi Acharjee, Rajshree Pal and Sugandh Sharma
13. Histone deacetylase as a potential therapeutic target for memory disorders
Mahendra Kumar Thakur
14. Histone deacetylases in Neurodegeneration
Amit Mishra
15. Role of Deubiquitinases in Regulating Tau Acetylation and Autophagic Clearance in Alzheimer’s Disease
Poornima Priyadarshini
16. Histone deacetylases in Neurodegeneration and neuronal plasticity
Bhupesh Mehta
17. Experimental strategies to evaluate the impact of HDACs on the epigenome: The ChiP-seq
Claudio Brancolini and Martina Minisini
18. Difluoromethyl-1,3,4-oxadiazoles are slow-binding substrate analog inhibitors of histone deacetylase 6 with unprecedented isotype selectivity
Christian Steinkühler

Über Autor(innen)

Chinnathambi, Subashchandrabose
Subashchandrabose Chinnathambi is Additional Professor Department of Neurochemistry National Institute of Mental Health and Neurosciences Hospital Bangalore, Karnataka, India.

Allen, Karen N.
Dr. Karen N. Allen works at the Department of Chemistry of the Boston University, the Metcalf Center for Science and Engineering

Christianson, David
After completing studies for the A.B., A.M., and Ph.D. degrees in chemistry at Harvard University, David W. Christianson joined the faculty of the University of Pennsylvania, where he is currently the Roy and Diana Vagelos Professor in Chemistry and Chemical Biology. At Penn, Christianson’s research focuses on the structural and chemical biology of the zinc-dependent histone deacetylases as well as enzymes of terpene biosynthesis. His research accomplishments have been recognized by several awards, including the Pfizer Award in Enzyme Chemistry and the Repligen Award in Chemistry of Biological Processes from the American Chemical Society, a Guggenheim Fellowship, and the Elizabeth S. and Richard M. Cashin Fellowship from the Radcliffe Institute for Advanced Study at Harvard University. Christianson is also a dedicated classroom teacher, and his accomplishments in this regard have been recognized by the Lindback Award for Distinguished Teaching at Penn and a Rhodes Trust Inspirational Educator Award from Oxford University. Christianson has also held visiting professorships in the Department of Biochemistry at Cambridge University and the Department of Chemistry and Chemical Biology at Harvard University. Christianson has served with Prof. Anna Pyle as Co-Editor-in-Chief of Methods in Enzymology since 2015.