Asymptotics of Elliptic and Parabolic PDEs

and their Applications in Statistical Physics, Computational Neuroscience, and Biophysics
1. Auflage 2018
ISBN: 978-3-319-76894-6
Verlag: Springer

Buch, Englisch, Band 199, 444 Seiten, Format (B × H): 155 mm x 235 mm, Gewicht: 6922 g

Reihe: Applied Mathematical Sciences

This is a monograph on the emerging branch of mathematical biophysics combining asymptotic analysis with numerical and stochastic methods to analyze partial differential equations arising in biological and physical sciences.

In more detail, the book presents the analytic methods and tools for approximating solutions of mixed boundary value problems, with particular emphasis on the narrow escape problem. Informed throughout by real-world applications, the book includes topics such as the Fokker-Planck equation, boundary layer analysis, WKB approximation, applications of spectral theory, as well as recent results in narrow escape theory. Numerical and stochastic aspects, including mean first passage time and extreme statistics, are discussed in detail and relevant applications are presented in parallel with the theory.

Including background on the classical asymptotic theory of differential equations, this book is written for scientists of various backgrounds interested inderiving solutions to real-world problems from first principles.

Zielgruppe

Research

Autoren/Hrsg.

Holcman, David

Schuss, Zeev

Fachgebiete

• Mathematik | Informatik Mathematik Numerik und Wissenschaftliches Rechnen Angewandte Mathematik, Mathematische Modelle
• Naturwissenschaften Biowissenschaften Angewandte Biologie Biomathematik
• Naturwissenschaften Biowissenschaften Angewandte Biologie Bioinformatik
• Naturwissenschaften Physik Angewandte Physik Biophysik
• Naturwissenschaften Physik Physik Allgemein Theoretische Physik, Mathematische Physik, Computerphysik
• Mathematik | Informatik Mathematik Mathematische Analysis Differentialrechnungen und -gleichungen
• Naturwissenschaften Biowissenschaften Angewandte Biologie Biophysik

Inhaltsverzeichnis

Part I. Singular Perturbations of Elliptic Boundary Problems.- 1 Second-Order Elliptic Boundary Value Problems with a Small Leading Part.- 2 A Primer of Asymptotics for ODEs.- 3 Singular Perturbations in Higher Dimensions.- 4 Eigenvalues of a Non-self-adjoint Elliptic Operator.- 5 Short-time Asymptotics of the Heat Kernel.- Part II Mixed Boundary Conditions for Elliptic and Parabolic Equations.- 6 The Mixed Boundary Value Problem.- 7 THe Mixed Boundary Value Problem in R2.- 8 Narrow Escape in R3.- 9 Short-time Asymptotics of the Heat Kernel and Extreme Statistics of the NET.- 10 The Poisson–Nernst–Planck Equations in a Ball.- 11 Reconstruction of Surface Diffusion from Projected Data.- 12 Asymptotic Formulas in Molecular and Cellular Biology.- Bibliography.- Index.

Über Autor(innen)

David Holcman is an applied mathematician and computational biologist. He developed mathematical modeling and simulations of molecular dynamics in micro-compartments in cell biology using stochastic processes and PDEs. He has derived physical principles of physiology at various scales, including diffusion laws in dendritic spines, potential wells hidden in super-resolution single particle trajectories or first looping time in polymer models. Together with Zeev Schuss, he developed the Narrow escape and Dire strait time theory.
Zeev Schuss is an applied mathematician who significantly shaped the field of modern asymptotics in PDEs with applications to first passage time problems. Methods developed have been applied to various fields, including signal processing, statistical physics, and molecular biophysics.