Buch, Englisch, 520 Seiten, Format (B × H): 174 mm x 229 mm, Gewicht: 934 g
Buch, Englisch, 520 Seiten, Format (B × H): 174 mm x 229 mm, Gewicht: 934 g
ISBN: 978-0-12-372484-7
Verlag: Elsevier Science Publishing Co Inc
Living cells are constantly sensing environmental changes, and their abilities to sense these changes and adapt to them are essential for their survival. In bacteria, histidine kinases are the major sensors for these environmental stresses, enabling cells to adapt to new growth conditions.
Written by leading experts in the field, this book provides an up-to-date and comprehensive review on the structure and function of histidine kinases. It also provides extensive information on the physiological roles of histidine kinases in bacteria and eukaryotes.
An an essential reference for cell biologists, microbiologists, molecular biologists, and biochemists interested in signal transduction. Experimental biologists and pharmacologists studying signal transduction systems in living organisms will also find it a valuable research tool.
Zielgruppe
Biochemists; molecular biologists, experimental biologists; pharmocologists; pharmaceutical companies with R&D programs in broad spectrum antibiotics; and specialists studying signal transduction systems in living organisms.
Autoren/Hrsg.
Fachgebiete
Weitere Infos & Material
Preface
Contributors
1 Histidine Kinases: Introductory Remarks
Introduction
Basic Structure of Histidine Kinases (HKs)
Uniqueness of HKs
Difference between HKs and Ser/Thr/Tyr Kinases
Signal Transduction Mechanism
Regulation of Kinase and Phosphatase Activities: Switch Model and Rheostat Model
Concluding Remarks
References
2 The Histidine Kinase Family: Structures of Essential Building Blocks
Introduction
Kinase/Phosphatase Core Domain
Phosphotransfer Domain
Considerations on Domain Interactions
Concluding Remarks
References
3 Regulation of Porins in Escherichia coli by the Osmosensing Histidine Kinase~hosphatase EnvZ
Introduction
Domain A Is the Catalytic Domain
Domain B Is the Catalysis-Assisting and ATP-Binding Domain
Monomeric Histidine Kinase: Topological Arrangement between Domain A and Domain B
Role of DNA in EnvZ Function
Stoichiometric Complex Formation between EnvZ and OmpR
Regulation of Kinase and Phosphatase Activities: Switch Model versus Rheostat Model
Mechanism of Osmoregulation
Concluding Remarks
References
4 Structure and Function of CheA, the Histidine Kinase Central to Bacterial Chemotaxis
Introduction
Modular Structure of CheA
A Superfamily of Histidine Kinases and ATPases
Nucleotide Binding by CheA P4 and the GHL ATPases
ATP Hydrolysis and Conformation of P4
HPt Domain P1 and Phosphoryl Transfer
P2 Domain and Response Regulator Coupling
A Separate Dimerization Domain
Receptor Coupling by the P5 Regulatory Domain
Is Flexibility between Domains Important for Signaling?
Controlling Protein-Protein Interactions with ATP
Prospects for the Design of Antibiotics Directed at CheA<
