Pharmacogenomics Transporters

1. Auflage 2013
ISBN: 978-0-470-92794-6
Verlag: Wiley

Buch, Englisch, 440 Seiten, Format (B × H): 161 mm x 240 mm, Gewicht: 827 g

Highlighting the internationally hot topic of pharmacogenomics and its influence on drug therapy, Pharmacogenomics of Human Drug Transporters reviews individual drug transporters, including specific transporter families and clinical implications. This book serves as a comprehensive guide to drug transporters that influence the absorption, distribution, and elimination of drugs in the body, and the reasons why individuals differ. The authors include sufficient detail to enable non-specialists to understand the principles and techniques and provides a practical, hands-on resource for researchers in pharmaceutical industry, academic research, and government agencies.

Autoren/Hrsg.

Ishikawa, Toshihisa

Kim, Richard B

König, Jörg

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Pharmakotherapie, Psychopharmakotherapie
• Wirtschaftswissenschaften Wirtschaftssektoren & Branchen Fertigungsindustrie Pharmaindustrie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Pharmakologie, Toxikologie
• Technische Wissenschaften Verfahrenstechnik | Chemieingenieurwesen | Biotechnologie Pharmazeutische Technologie
• Naturwissenschaften Chemie Chemie Allgemein Pharmazeutische Chemie, Medizinische Chemie

Inhaltsverzeichnis

PREFACE vii

CONTRIBUTORS ix

CHAPTER 1 INTRODUCTION TO PHARMACOGENOMICS OF DRUG TRANSPORTERS 1
Marianne K. DeGorter and Richard B. Kim

CHAPTER 2 ADME PHARMACOGENOMICS IN DRUG DEVELOPMENT 13
Liangfu Chen and Joseph W. Polli

CHAPTER 3 REGULATORY PERSPECTIVE ON PHARMACOGENOMICS OF DRUG-METABOLIZING ENZYMES AND TRANSPORTERS 39
Lei Zhang, Gilbert J. Burckart, Lawrence J. Lesko and Shiew-Mei Huang

CHAPTER 4 THE PHARMACOGENOMICS OF MEMBRANE TRANSPORTERS PROJECT 73
Sook Wah Yee, Deanna L. Kroetz and Kathleen M. Giacomini

CHAPTER 5 EMERGING NEW TECHNOLOGY OF SNP TYPING 109
Toshihisa Ishikawa and Yoshihide Hayashizaki

CHAPTER 6 OATP1A2, OAT1, AND OAT3 125
Rommel G. Tirona

CHAPTER 7 OATP1B1, OATP1B3, AND OATP2B1 141
J¨org K¨onig and Martin F. Fromm

CHAPTER 8 OCT (SLC22A) AND OCTN FAMILY 171
Sophie L. Stocker, Arian Emami Riedmaier, Matthias Schwab and Kathleen M. Giacomini

CHAPTER 9 MATE (SLC47) FAMILY 209
Atsushi Yonezawa and Ken-ichi Inui

CHAPTER 10 PEPT (SLC15A) FAMILY 223
Tomoko Sugiura, Saki Umeda, Akira Tsuji and Yukio Kato

CHAPTER 11 NUCLEOSIDE TRANSPORTERS (SLC28 AND SLC29) FAMILY 243
M´?riam Molina-Arcas and Marc¸al Pastor-Anglada

CHAPTER 12 P-GLYCOPROTEIN (MDR1/ABCB1) 271
Ingolf Cascorbi

CHAPTER 13 BSEP (ABCB11) 295
Bruno Stieger and Gerd A. Kullak-Ublick

CHAPTER 14 BCRP (ABCG2) 311
Agnes Basseville, Susan E. Bates, William D. Figg and Alex Sparreboom

CHAPTER 15 MRP2 (ABCC2) AND MRP3 (ABCC3) 345
Anne T. Nies

CHAPTER 16 MRP4 (ABCC4) 365
Satish B. Cheepala, Mugdha Sukthankar and John D. Schuetz

CHAPTER 17 MRP8 (ABCC11) 387
Yu Toyoda and Toshihisa Ishikawa

CHAPTER 18 FUTURE PERSPECTIVES 401
Toshihisa Ishikawa and Joseph Ware

INDEX 417

Über Autor(innen)

TOSHIHISA ISHIKAWA, PhD, is Senior Scientist at RIKEN Yokohama Institute and Professor of Biochemistry, Molecular Biology, and Pharmacogenomics at Yokohama City University's Graduate School of Medicine. Previously, Dr. Ishikawa was the Director of the Department of Research Technology Development at Pfizer, Japan. A recipient of the Achievement Award from the International Life Sciences Institute (ILSI), Dr. Ishikawa is also the cofounder of the International Transporter Consortium (ITC).

RICHARD B. KIM, MD, FRCPC, is Professor and Chair of the Division of Clinical Pharmacology and Associate Chair for Research in the Department of Medicine at the University of Western Ontario. He is a Fellow of the American Association of Pharmaceutical Scientists and an elected member of the American Society for Clinical Investigation.

JÖRG KÖNIG, PhD, is Professor and Head of the Molecular Biology Laboratories in the Department of Clinical Pharmacology at the Friedrich-Alexander Universität Erlangen-Nürnberg.