Alternatives to Animal Models

Opportunities, Challenges and Future Directions in Non-Animal Biomedical Research
Erscheinungsjahr 2026
ISBN: 978-981-9208-70-8
Verlag: Springer

Buch, Englisch, 472 Seiten, Format (B × H): 155 mm x 235 mm

This book focusses on the shift away from animal testing towards alternative approaches in toxicology, drug development, and biomedical research. It draws attention to the difficulties and possibilities brought about by this change, highlighting moral issues, legal frameworks, and real-world applications.

Biomedical research is changing quickly due to the increasing ethical pressure to minimize animal testing. Traditional research methods are coming under more and more scrutiny as a result of public concern over animal welfare. Concurrently, novel approaches like organ-on-a-chip technology, 3D bioprinting, and in silico models present encouraging substitutes. In order to provide academicians and policymakers with up-to-date information on developing trends in this sector, this book attempts to compile existing knowledge on the aforementioned innovations beyond animal testing. The different chapters emphasize the potential solutions and opportunities offered by alternative methods. They provide practical insights and strategies for researchers and policymakers looking to transition away from animal models. The book also addresses the critical topic of economic efficiency by showing how affordable non-animal models may be, which could lessen the financial burden of research.

The book serves as a significant educational resource, specifically designed for students, educators, researchers and health care professionals. This will aid early career researchers having limited resources in generating preliminary data and proof of concept for further research. It also addresses the market's need for actionable information by providing practical advice on how healthcare professionals can use these cutting-edge tactics in promoting emergency use of drug and delivery system without actually testing them in vivo.

Zielgruppe

Research

Autoren/Hrsg.

Jain, Aakanchha

Mishra, Neeraj

Fachgebiete

• Naturwissenschaften Biowissenschaften Angewandte Biologie Bioinformatik
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Pharmakologie, Toxikologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Onkologie, Krebsforschung
• Interdisziplinäres Wissenschaften Wissenschaften Interdisziplinär Neurowissenschaften, Kognitionswissenschaft
• Mathematik | Informatik EDV | Informatik Angewandte Informatik Bioinformatik
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Immunologie

Inhaltsverzeichnis

Chapter 1. Introduction to non-animal modelling approaches for testing of drug and drug products.- Chapter 2. Shaping the future of hepatic cancer research: alternatives beyond animal models.- Chapter 3. Neural Cell Cultures and 3D Co-Culture Systems.- Chapter 4. High-Throughput Screening with Alternative Models.- Chapter 5. Non -animal modelling approaches for colorectal cancer research.- Chapter 6. Non-animal modelling approaches for lung cancer.- Chapter 7. Non-animal modelling approaches for cervical and breast cancer.- Chapter 8. Non-animal modelling approaches for glioblastoma.- Chapter 9. Interplay between Non-animal modelling approaches and In vivo approaches for cancer.- Chapter 10. Non- animal modelling approaches for neurodegenerative disorder.- Chapter 11. Organoid model for neurological disorders.- Chapter 12. Alternative Methods for Developmental Toxicity Testing.- Chapter 13. Human 3d-skin models for wound healing.- Chapter 14. Human reconstructed 3d-skin model for pigmentation disorders.- Chapter 15. Challenges, future prospects and ethical issues of non-animal modelling approaches in infectious disease.- Chapter 16. Non-animal modelling approaches for Inflammatory disorders.- Chapter 17. Non-animal models in drug resistance research: emerging approaches and future directions.- Chapter 18. Non-animal modelling approaches for human vaccines.- Chapter 19. Validation techniques for non-animal modelling approaches.- Chapter 20. Regulatory considerations for non-animal modelling approaches.

Über Autor(innen)

Dr. Aakanchha Jain obtained her Ph.D. from Dr. H.S. Gour Central University, Sagar, as INSPIRE-DST Fellow. Currently, she is working as an Assistant Professor, Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER), Ahmedabad, India. She has 15 years of experience as a formulation scientist. Dr. Jain is a guest reviewer for various journals like Carbohydrate Polymers, Pharmaceutical Development and Technology, ACS Omega, Phytomedicine Plus, Journal of Biomaterials Applications, etc. She has published over 70 peer-reviewed articles, 31 book chapters and edited two books [h index 23; i10 index 49, citations 2115]. Dr. Jain is a formulation scientist working in the field of development, characterization and evaluation (in vitro and in vivo) of novel drug delivery systems for the delivery of drugs and proteins/ peptides for the management of cancer and skin related diseases. Dr. Jain is the recipient of various Awards, Gour Samman 2010, Nagarjuna Award 2010, Ranbaxy Science Scholar 2012, M.P. Young Scientist Award 2018 to name a few.

Dr. Neeraj Mishra is working as Professor and Head, Department of Pharmaceutics in Amity Institute of Pharmacy, Gwalior since July 2019. He has around twenty years of teaching and research experience.  He has more than 140 publications of International and National repute in recent concepts of novel drug delivery systems, localized drug delivery, targeted and controlled drug delivery of nanocarriers/ microparticles for the treatment of breast, colon cancer, and neurodegenerative disorders. Dr. Mishra has supervised 30 M Pharm and 2 PhD students. Dr. Mishra has more than 4200 citations with h- index 36. The total cumulative Impact Factor of his published papers is more than 500 (as per SCOPUS). He has also written 25 Books and 45 book chapters in reputed pubication. He has also been granted 3 international patents and 2 Indian patents.  Dr. Mishra is recipient of “Distinguished Professor Award” 2019 from DST-NSTMIS, SPAICS, Indore, and M.P. in September 2019. Dr. Mishra has received the “Distinguished Professor Award '' 2021 from Indian Pharmaceutical Association, MP State Branch, Indore. Dr Mishra has received Best Academician Award in the Indian Pharmacy Graduate Association, M.P. State International Conference held on 06th May 2023 at DAVV Auditorium, Indore, India. Recently, honored to be in World Top 2% Scientists by prestigious Stanford University, CA, USA and by reputed publisher in 2025.