Epigenetics in Neurodegenerative Disorders

Mechanisms, Biomarkers, and Therapeutic Perspectives
Erscheinungsjahr 2026
ISBN: 978-3-032-22577-1
Verlag: Springer Nature Switzerland AG

Buch, Englisch, 428 Seiten, Format (B × H): 155 mm x 235 mm

Reihe: Epigenetics and Human Health

Epigenetic mechanisms are increasingly recognised as key contributors to neurodegenerative disease processes, shaping the molecular pathways involved in ageing, neuroinflammation and neuronal dysfunction. This volume provides an integrated overview of how DNA methylation, histone modifications, chromatin remodelling, non-coding RNAs and epitranscriptomic regulation influence the onset and progression of neurodegenerative disorders.

Covering a broad spectrum of conditions—including Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, frontotemporal dementia, prion and prion-like diseases, amyotrophic lateral sclerosis and multiple sclerosis—the book examines how epigenetic alterations interact with genetic, metabolic and environmental factors to drive disease pathology. Contributors detail advances in biomarker development, such as DNA methylation profiles, differentially methylated and hydroxymethylated regions, extracellular vesicles and neurofilament light chain, along with emerging therapeutic strategies involving CRISPR-based epigenetic editing, histone deacetylase inhibitors and DNA methyltransferase inhibitors.

Additional chapters explore cross-disease themes including neuroinflammatory signalling, gut–brain epigenetic interactions, chromatin dynamics and ageing-related epigenetic drift, offering insights into translational research and precision medicine. This volume serves as a valuable resource for researchers, clinicians and advanced students in neuroscience, molecular biology, genetics and biomedical sciences seeking to understand the role of reversible epigenetic regulation in neurodegenerative disorders.

Zielgruppe

Research

Autoren/Hrsg.

Kalkan, Rasime

Fachgebiete

• Naturwissenschaften Biowissenschaften Molekularbiologie
• Naturwissenschaften Biowissenschaften Biowissenschaften Genetik und Genomik (nichtmedizinisch)
• Interdisziplinäres Wissenschaften Wissenschaften Interdisziplinär Neurowissenschaften, Kognitionswissenschaft

Inhaltsverzeichnis

Epigenetic Regulation of Neurodegenerative Diseases: Molecular Pathways and Cross-Disease Insights.- Epigenetics in Neurodegenerative Disease Treatment.- Implications of the Interplay Between the Epigenetic Modifications and Gut Microbiota in Neurodegenerative Diseases During Aging.- Epigenetic Regulation of Neuroinflammation.- Frontotemporal Dementia and Epigenetics.- Epigenetic and Epitranscriptomic Changes in Prion and Prion-Like Diseases.- Epigenetic Biomarkers for Neurodegenerative Disorders.- Amyotrophic Lateral Sclerosis (ALS) and Epigenetics.- Epigenetic Dysregulation in Neurodegenerative Disorders: Multivariate Mechanisms and Translational Opportunities.- Epigenetics in Multiple Sclerosis: Alterations in Histone Methylation and Clinical Applications.- Epigenetics and Huntington’s Disease.- Epigenetics and Parkinson’s Disease.- Epigenetic Landscape of Parkinson’s Disease: Chromatin Remodelling and Non-coding RNAs in Disease Pathogenesis.

Über Autor(innen)

Rasime Kalkan is a Professor of Medical Genetics at the European University of Lefke. Professor Rasime Kalkan completed her PhD in the Department of Medical Genetics at the Eskisehir Osmangazi University in Turkey. She served as a member of the Department of Medical Genetics at Near East University from November 2011 to June 2022. She served as Chair of the Department of Molecular Biology and Genetics in the Arts and Sciences Faculty at Near East University (2020–2022). She has been a member of the Turkish Medical Genetics Association since 2006. She worked on genetic and epigenetic alterations in brain tumours, especially in glioblastoma, during her PhD. She has edited books and journals, published numerous articles in peer-reviewed journals, and authored several chapters for various national and international books. She served as a project coordinator on many research projects. Her research is focused on the identification of epigenetic and genetic alterations in cancer, obesity, hypertension and post-menopausal term.