Drug Development for Malaria

Novel Approaches for Prevention and Treatment
1. Auflage 2022
ISBN: 978-3-527-34860-2
Verlag: WILEY-VCH

Buch, Englisch, 400 Seiten, Format (B × H): 170 mm x 244 mm, Gewicht: 907 g

Drug Development for Malaria

Provides readers with first-hand advice for the development of novel antimalarial drugs

This book provides a systematic overview of antimalarial drug development and presents a wealth of data and insight from drug developers across three continents, including many from countries where the disease is endemic. Throughout, the contributions have been written with the drug developer in mind, highlighting challenges but also opportunities for the successful development of effective antimalarial drugs. Case studies and method-oriented chapters provide an abundance of practical first-hand advice on how to successfully develop an antimalarial drug.

Key topics covered in the book include: - The performance of current drugs and therapies, the influence of formulation and targeted delivery, and strategies to overcome drug resistance.

- Technologies and approaches for development of novel drugs, such as assays, computer-aided drug design, known and potential drug targets, and natural sources for novel antimalarial compounds
- Vaccination as an alternative to drug therapy

For chemists and other professionals working in industries related to medicine and pharmaceuticals, this book provides a completely comprehensive overview of the current state of novel antimalarial drugs and how they can be developed in an efficient and cost-effective manner.

Autoren/Hrsg.

Kendrekar, Pravin

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Infektionskrankheiten
• Naturwissenschaften Chemie Chemie Allgemein Pharmazeutische Chemie, Medizinische Chemie
• Naturwissenschaften Biowissenschaften Parasitologie

Inhaltsverzeichnis

INTRODUCTION
Past, Present and Future Drug Development for Malaria
 
CHALLENGES AND OPPORTUNITIES IN MALARIA THERAPY
Scientific Challenges and Treatment Opportunities in the Face of Shifting Malaria Epidemiology
Emerging Formulation Technologies against Malaria Resurgence
Targeted Drug Delivery for Malarial Therapy
The Imminent Threat of Antimalarial Drug Resistance
Current Therapies and New Drug Targets for the Future Drug Development of Drug Resistant Malaria
 
DRUG DEVELOPMENT
Assays for Antimalarial Drug Discovery
Aminoacyl-tRNA Synthetases as Malarial Drug Targets: A Structural Biology Perspective
Natural Products as a Source for Antimalarial Drug Development Process - An Overview
Mushroom-Derived Products as an Alternative Antimalarial Therapeutics: A Review
Discovery and Trends of 8-Aminoquinoline and 4-Aminoquinoline Classes of Antimalarials
Antimalarial Activity of Novel Class of 1,3-Benzoxaborole Derivatives Containing 1, 3, 4-Oxadiazole Moiety
 
VACCINE PERSPECTIVE
Recent Advances in Malaria Vaccine Development
Toll-Like Receptor-Based Adjuvants - A Gateway Towards Improved Malaria Vaccination
Pure TLR7 Agonistic BBIQ is a Potential Adjuvant against P. Berghei ANKA Challenge in Vivo

Über Autor(innen)

Pravin Kendrekar studied chemistry at Swami Ramanand Teerth Marathwada University (India) and completed his Ph.D. in Organic Chemistry at Nagoya University of Technology (Japan). After post-doctoral work at Ben Gurion University (Israel) and the University of the Free State (South Africa), he joined the Central University of Technology at Bloemfontein (South Africa) in 2017, where he is currently a group leader in the Unit for Drug Discovery Research. He also holds a position as business development director with T&T Pharma Care in Thane (India). The primary focus of his work is in antimalarial therapy.