MOTONEURONE & MUSCLE FIBRES MPS

C C
Erscheinungsjahr 2006
ISBN: 978-0-19-852655-1
Verlag: ACADEMIC

Buch, Englisch, 360 Seiten, Print PDF, Format (B × H): 175 mm x 250 mm, Gewicht: 790 g

The Motoneurone and its Muscle Fibres presents a state-of-the-art summary of knowledge concerning the motoneurones, vital for innervating and commanding skeletal muscles. No muscle action would be possible without motoneurones. These cells are therefore absolutely essential for the execution of normal behaviour and for life support. It is their degeneration that leads to various kinds of motoneurone disease (e.g. ALS) that are often ultimately lethal. However, the study of motoneurones is also important for general insights as to how neurones work, because the motoneurone is probably the best understood kind of nerve cell so far in neuroscience. Motoneurones of the spinal cord were the first type of central nerve cell to be subjected to detailed physiological measurements, and much is known about how their activity is regulated by synapses from other central neurones. For most of the individual neurones within the central nervous system, the precise functional tasks are difficult to define. However, for motoneurones much is now known about their short- and long-term interactions with their main targets, the skeletal muscle fibres. Functions of neurones must be analyzed in relation to the response properties of their target cells. Therefore, this book deals with both, summarizing classical as well as recent knowledge concerning the motoneurone and its muscle fibres. This is the first time that so many aspects of this broad subject matter are treated in one comprehensive monograph.

Autoren/Hrsg.

Kernell, Daniel

Fachgebiete

• Naturwissenschaften Biowissenschaften Molekularbiologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Vorklinische Medizin: Grundlagenfächer Physiologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Pathologie, Cytopathologie, Histopathologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Innere Medizin
• Sozialwissenschaften Psychologie Allgemeine Psychologie Biologische Psychologie, Neuropsychologie
• Naturwissenschaften Biowissenschaften Biowissenschaften Neurobiologie, Verhaltensbiologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Vorklinische Medizin: Grundlagenfächer Humangenetik
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Neurologie, Klinische Neurowissenschaft

Inhaltsverzeichnis

- 1: Why bother about motoneurones?

- 2: Basic neuromuscular properties

- 3: Muscle unit properties and specializations

- 4: Neuromuscular transmission

- 5: Motoneurones: morphology, cytology and topographical organization

- 6: Motoneurones: electrophysiology

- 7: Motoneurones: synaptic control

- 8: Motoneurone populations and the gradation of muscle force

- 9: Short-term plasticity: fatigue and potentiation

- 10: Denervation and reinnervation

- 11: Long-term plasticity

- 12: Genetic specification and lifespan development

Über Autor(innen)

Daniel Kernell grew up in Stockholm and studied medicine at the Karolinska Institutet. From 1961-1972 he was associated with the Nobel Institute for Neurophysiology (Karolinska Institutet). After being awarded his PhD in 1965, he spent his postdoctoral period in Oxford (UK) 1966-1967. He moved to the Netherlands in 1972, where he worked as a professor of Neurophysiology at the University of Amsterdam and, later, as a professor of Medical Physiology at the University of Groningen. Most of his research work has concerned the neuromuscular system (motoneurones and muscles), and his results have been published in many articles in international scientific journals and presented at international symposia and congresses.