Advances in Mitochondrial Drug Delivery

From Molecular Mechanisms to Clinical Translation
Erscheinungsjahr 2027
ISBN: 978-0-443-44232-2
Verlag: Elsevier Science

Buch, Englisch, 400 Seiten, Format (B × H): 191 mm x 235 mm, Gewicht: 449 g

Advances in Mitochondrial Drug Delivery: From Molecular Mechanisms to Clinical Translation addresses the critical need for a comprehensive resource on mitochondrial-targeted drug delivery systems. As recent advancements in drug delivery systems (DDS) have shown substantial promise in treating diseases linked to mitochondrial dysfunction, there is a pressing demand for a consolidated reference that covers both the foundational aspects and the latest innovations in this field. The book's Table of Contents encompasses a wide range of topics, beginning with the fundamentals of mitochondrial biology and drug delivery, followed by various mitochondrial-targeted drug delivery strategies. It further explores advanced applications of these systems in treating cancer, neurodegenerative diseases, cardiovascular conditions, and more. Additionally, the book discusses future directions, clinical translation, and regulatory challenges, ensuring a holistic view of the subject matter. Advances in Mitochondrial Drug Delivery offers significant benefits to researchers, students, and professionals in pharmaceutical sciences and nanotechnology. By integrating diverse perspectives from leading experts, the book serves as an essential resource for understanding the complexities of mitochondrial-targeted therapies, thereby fostering advancements in drug delivery systems and therapeutic strategies.

Autoren/Hrsg.

Kesharwani, Prashant

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Pharmakologie, Toxikologie
• Wirtschaftswissenschaften Wirtschaftssektoren & Branchen Fertigungsindustrie

Inhaltsverzeichnis

SECTION 1: Fundamentals of Mitochondrial Biology & Drug Delivery
1. Introduction to Mitochondrial Structure and Function
2. Mitochondrial Dysfunction and Its Role in Disease Pathophysiology
3. Role of Mitochondria in Cancer Metabolism
4. Cellular and Subcellular Targeting: Challenges in Mitochondrial Drug Delivery
5. Mechanisms of Mitochondrial Targeting
6. Mitochondrial Biogenesis and Metabolic Reprogramming

SECTION 2: Mitochondria-Targeted Drug Delivery Strategies
7. Concept of Mito-Porters, Mitochondriotropics, and Mitocans
8. Lipophilic Cation-Based Mitochondrial Targeting
9. Mitochondria-Penetrating Peptides (MPPs) and Peptide-Based Targeting
10. Nanoparticle-Based Mitochondrial Targeting
11. Mitochondria-Targeted Prodrugs and Small Molecule Therapeutics
12. Transporter-Mediated Mitochondrial Drug Delivery
13. Mitochondria-Targeted Gene Therapy and RNA Delivery
14. Stimuli-Responsive Mitochondria-Targeted Drug Delivery
15. Mitochondria-Targeted Photodynamic and Photothermal Therapy

SECTION 3: Applications of Mitochondria-Targeted Therapeutics
16. Mitochondria-Targeted Drug Delivery for Cancer Therapy
17. Mitochondria-Targeted Therapeutics for Neurodegenerative Diseases
18. Mitochondria in Cardiovascular and Metabolic Diseases
19. Mitochondria-Targeted Approaches for Infectious Diseases
20. Emerging Therapies for Mitochondrial Genetic Disorders

SECTION 4: Future Directions, Clinical Translation, and Regulatory Aspects
21. Ethical Considerations in Mitochondrial Gene Therapy
22. Advances in Mitochondria-Targeted Drug Discovery and Development
23. Clinical Translation, Regulatory Challenges, and Future Perspectives

Über Autor(innen)

Kesharwani, Prashant
Dr. Prashant Kesharwani is an Assistant Professor of Pharmaceutics at Dr. Harisingh Gour Vishwavidyalaya (A Central University), Sagar, India. He has over 12 years of teaching and research experience, specializing in translational nanomedicine, polymeric biomaterials, targeted drug delivery, and nanoengineered drug delivery systems. He has authored more than 400 peer-reviewed publications in reputed international journals and edited over 30 international books. His research has received widespread recognition, with an h-index exceeding 100. He has secured several competitive research grants from national funding agencies and received prestigious honors, including the USERN Laureate Award and the SERB–Ramanujan Fellowship. His research interests include nanomedicine, targeted and stimuli-responsive drug delivery, polymeric nanocarriers, and translational pharmaceutical research. He actively contributes to academic mentoring, scientific research, and scholarly publishing.