Crispr Therapeutics Delivery Strategies

Erscheinungsjahr 2027
ISBN: 978-0-443-45212-3
Verlag: Elsevier Science

Buch, Englisch, 400 Seiten, Format (B × H): 191 mm x 235 mm, Gewicht: 449 g

CRISPR Therapeutics Delivery Strategies is a structured and comprehensive resource in the rapidly evolving field of CRISPR technology. As CRISPR-Cas systems translate to therapeutics, this reference provides critical insights into the challenges and advancements in effective delivery mechanisms. The book captures the essence of CRISPR's transformative potential in gene therapy, targeted cancer treatments, and personalized medicine, while also highlighting the importance of innovative delivery strategies to overcome existing barriers. The contents of the book offers a systematic exploration of CRISPR technology, beginning with foundational concepts and progressing to targeted drug delivery strategies. Each chapter explore specific applications, including CRISPR in cancer therapy, gene editing for rare diseases, and overcoming delivery barriers such as the blood-brain barrier. Additionally, ethical and regulatory considerations are addressed, providing a holistic view of the current landscape and future directions in CRISPR research. CRISPR Therapeutics Delivery Strategies serves as an essential resource for students, researchers, and professionals in the fields of pharmacology, biotechnology, and gene therapy. By compiling cutting-edge research and expert perspectives, this reference helps pharmaceutical scientists to navigate the complexities of CRISPR technology and its applications.

Autoren/Hrsg.

Kesharwani, Prashant

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Pharmakologie, Toxikologie
• Wirtschaftswissenschaften Wirtschaftssektoren & Branchen Fertigungsindustrie

Inhaltsverzeichnis

SECTION 1: FUNDAMENTALS OF CRISPR TECHNOLOGY: BREAKTHROUGH IN GENETIC ENGINEERING
1.Introduction to CRISPR: Overview and historical milestones in gene editing
2. Basics of drug delivery and gene editing
3. Understanding the science behind CRISPR mechanism
4. Potential of CRISPR technology in drug delivery
5. Role of CRISPR in targeted delivery: Synergy of nanoparticles and CRISPR

SECTION 2: CRISPR BASED TARGETED DRUG DELIVERY STRATEGIES
6. Viral Vectors and CRISPR: A Common Approach to Drug Delivery
7. Non-Viral Delivery Systems: CRISPR and Alternative Carriers
8. CRISPR in RNA Drug Delivery: mRNA and Beyond

SECTION 3: APPLICATIONS OF CRISPR BASED TARGETED THERAPEUTICS
9. CRISPR in Cancer Drug Delivery: Precision Medicine at Work
10. CRISPR-Based Gene Editing for Rare Diseases
11. Delivering CRISPR to the Brain: Overcoming the Blood-Brain Barrier
12. Immunomodulation and CRISPR in Drug Delivery
13. CRISPR in Vaccine Development and Delivery
14. Overcoming Delivery Barriers: Stability, Bioavailability, and Half-Life

SECTION 4: CHALLENGES, ETHICAL AND REGULATORY ASPECTS
15. CRISPR for Chronic Diseases: Challenges in Long-Term Therapeutic Approaches
16. Safety and Ethical Concerns in CRISPR Drug Delivery
17. Legal, and Social Implications of CRISPR in Drug Delivery
18. Regulatory Frameworks and Oversight in CRISPR-Based Therapies

SECTION 5: FUTURE DIRECTIONS, CLINICAL TRIALS, AND CONCLUSION
19. CRISPR in Stem Cell Therapy: A Path to Regenerative Medicine
20. Clinical Trials: The Reality of CRISPR Drug Delivery
21. Innovative CRISPR Delivery Strategies: Future Directions
22. Conclusion: The Transformative Potential and Impact of CRISPR Drug Delivery Systems in Healthcare and Pharmaceutical Industries

Über Autor(innen)

Kesharwani, Prashant
Dr. Prashant Kesharwani is an Assistant Professor of Pharmaceutics at Dr. Harisingh Gour Vishwavidyalaya (A Central University), Sagar, India. He has over 12 years of teaching and research experience, specializing in translational nanomedicine, polymeric biomaterials, targeted drug delivery, and nanoengineered drug delivery systems. He has authored more than 400 peer-reviewed publications in reputed international journals and edited over 30 international books. His research has received widespread recognition, with an h-index exceeding 100. He has secured several competitive research grants from national funding agencies and received prestigious honors, including the USERN Laureate Award and the SERB–Ramanujan Fellowship. His research interests include nanomedicine, targeted and stimuli-responsive drug delivery, polymeric nanocarriers, and translational pharmaceutical research. He actively contributes to academic mentoring, scientific research, and scholarly publishing.