Buch, Englisch, Band 53, 534 Seiten, Paperback, Format (B × H): 170 mm x 244 mm, Gewicht: 947 g
Buch, Englisch, Band 53, 534 Seiten, Paperback, Format (B × H): 170 mm x 244 mm, Gewicht: 947 g
Reihe: Handbook of Experimental Pharmacology
ISBN: 978-3-642-67399-3
Verlag: Springer
Zielgruppe
Research
Weitere Infos & Material
1 Ganglionic Transmission: Morphology and Physiology.- A. Pathways in the Autonomic Ganglia.- B. Synaptic Transmission in Autonomic Ganglia.- C. Summary.- References.- 2 Ganglionic Metabolism.- A. Carbohydrate Metabolism.- B. Stimulation.- C. Nonglucose Metabolites Substrates.- D. Lipids.- E. Amino Acids.- F. Uptake and Efflux of Amino Acids.- G. RNA Protein.- H. Protein.- References.- 3 Methods for the Examination of Ganglion-Blocking Activity.- A. Introduction.- B. General Physiological and Pharmacological Aspects of the Evaluation of Ganglion-Blocking Agents.- C. Pharmacological Methods.- D. Preparations Other Than Autonomic Ganglia Used for Evaluation of Ganglion-Blocking Agents.- E. Screening for Ganglion-Blocking Activity.- F. Evaluation of Non-Nicotinic Ganglion-Blocking Agents.- G. Methods for the Determination of Absorption, Distribution, and Excretion of Ganglion-Blocking Agents.- H. Clinical Testing of Ganglion-Blocking Agents.- J. Critical Appraisal of the Experimental Methods Used in the Evaluation of Ganglion-Blocking Agents.- K. Conclusions.- References.- 4a Relationship Between Chemical Structure and Ganglion-Blocking Activity. a) Quaternary Ammonium Compounds.- A. Introduction.- B. Structure-Activity Relationships in Different Structural Types of Quaternary Ganglion-Blocking Agents.- C. Conclusions.- References.- 4b Relationship Between Chemical Structure and Ganglion-Blocking Activity. b) Tertiary and Secondary Amines.- A. Introduction.- B. Structure-Activity Relationships in Different Structural Types of Non-Quaternary Ganglion-Blocking Agents.- C. Conclusions.- References.- 5 Locus and Mechanism of Action of Ganglion-Blocking Agents.- A. Introduction.- B. Competitive Blocking Agents.- C. Depolarising Agents.- D. Intraganglionic Distribution of Ganglion-Blocking Drugs.- Addendum.- References.- 6 Action of Ganglion-Blocking Agents on the Cardiovascular System.- A. Introduction.- B. Hypotensive Action.- C. Cardiac Function.- D. Systemic Vascular Beds.- I. Cerebral Circulation.- II. Renal Circulation.- III. Pulmonary Circulation.- IV. Splanchnic Circulation.- V. Limb Circulation.- E. Conclusions.- References.- 7 Action of Ganglion-Blocking Agents on the Gastrointestinal Tract.- A. Introduction.- B. Salivary Secretion.- C. Oesophagus and Cardiac Sphincter.- D. Gastric Motility.- E. Gastric Secretion.- F. Pancreatic Secretion.- G. Small Intestine.- H. Colon.- References.- 8 Absorption, Distribution, Fate, and Excretion of Ganglion-Blocking Compounds.- A. Introduction.- B. Onium Compounds.- C. Secondary and Tertiary Amines.- References.- 9 Nicotinic Ganglion-Stimulating Agents.- A. Introduction.- B. Pharmacological Ambiguities of Ganglionic Receptors.- C. Postjunctional Responses to Acetylcholine and Nicotinic Agents.- D. Blockade of Transmission by Nicotinic Drugs.- E. Denervated Ganglia.- F. Conclusions.- References.- 10 Non-Nicotinic Chemical Stimulation of Autonomic Ganglia.- A. Introduction.- B. Muscarinic Ganglion Stimulants.- C. 5-Hydroxytryptamine (5-HT) and Related Indolealkylamines.- D. Histamine.- E. Polypeptides.- F. Cardiac Glycosides.- G. Veratrum Alkaloids.- H. Batrachotoxin.- J. Inorganic Cations.- K. Conclusions.- References.- 11 Ganglion Activity of Centrally Acting Neurotropic Agents.- A. Introduction.- B. Methods.- C. Volatile Anaesthetics.- D. Central Nervous System Depressants.- E. Neuroleptics.- F. Antidepressants.- G. Anti-Manic Drugs.- H. Narcotic Analgesics.- J. Central Nervous System-Stimulant Drugs.- K. Tranquillisers.- L. Anticonvulsant Drugs.- References.- Note Added in Proof.- 12 Ganglionic Actions of Anticholinesterase Agents, Catecholamines, Neuro-Muscular Blocking Agents, and Local Anaesthetics.- A. Anticholinesterase Agents.- B. Catecholamines.- C. Neuromuscular Blocking Agents.- D. Local Anaesthetics.- E. Conclusions.- References.- 13 Ganglionic Activity of Cardiovascular Drugs.- A. Introduction.- B. Antihypertensive Drugs.- C. Vasoconstrictors.- D. Cardiotropic Drugs.- References.- 14 Ganglion-Blocking Agents in Internal Medicine.- A. Introduction.- B. Ganglion-Blocking Agents in the Treatment of Hypertension.- C. Ganglion-Blocking Agents in the Treatment of Peptic Ulcer.- References.- 15 Ganglion-Blocking Agents in Anaesthesiology.- A. Introduction.- B. General Characteristics of the Use of Ganglion-Blocking Agents for Artificial Hypotension.- C. Use of Artificial Vasodilatation for Various Surgical Interventions and Pulmonary Oedema.- References.- Author Index. V.V. Maisky.- Subject Index. V. V. Maisky.