Radiotheranostics - A Primer for Medical Physicists I

Physics, Chemistry, Biology and Clinical Applications
1. Auflage 2024
ISBN: 978-1-032-13897-8
Verlag: CRC Press

Buch, Englisch, 230 Seiten, Format (B × H): 183 mm x 260 mm, Gewicht: 636 g

Reihe: Series in Medical Physics and Biomedical Engineering

This book covers scientific, clinical, and educational aspects of radiotheranostics in cancer control. Setting the framework, the first volume defines radiotheranostics and describes the history of radionuclide therapy and theranostics, and the biology of cancer. It examines the clinical applications of unconjugated radionuclides, such as 131I and 223Ra, and of radionuclide-conjugated cancer-specific vectors: peptides, small molecules, antibodies, and nanoparticles; introduces clinical trials and drug development; and reviews epidemiological studies and the adverse effects of radionuclide therapy – both, radiation injuries and chemical toxicity. It presents the chemistry and physics of radionuclide production, discusses radioactivity measurements and traceability, and addresses various instrumentation aspects: calibration, quantitative imaging, and quality control. Volume I ends by considering the education, training, and competence of the radiotheranostic multidisciplinary team and summarizing the most important physics characteristics of theranostics today – including many to be expanded in the second volume – while offering a glimpse into tomorrow.

These topics will provide the foundation for the second volume to cover the dosimetric and radiation safety aspects, aiming to empower medical physicists to demonstrate to the cancer community how to improve cancer control and yield longer patient survival times.

Zielgruppe

Postgraduate and Professional

Autoren/Hrsg.

Borrás, Cari

Stabin, Michael G.

Fachgebiete

• Naturwissenschaften Physik Angewandte Physik Medizinische Physik
• Naturwissenschaften Physik Physik Allgemein
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Onkologie, Krebsforschung
• Naturwissenschaften Physik Quantenphysik Kernphysik
• Naturwissenschaften Physik Quantenphysik Radioaktivität
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Bildgebende Verfahren, Nuklearmedizin, Strahlentherapie Nuklearmedizin, PET, Radiotherapie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Bildgebende Verfahren, Nuklearmedizin, Strahlentherapie Radiologie, Bildgebende Verfahren

Inhaltsverzeichnis

Section I: Introduction. Chapter 1: What is radiotheranostics? Chapter 2: History of radionuclide therapy and theranostics. Chapter 3: Biological principles behind targeted radionuclide therapy for cancer. Section II: Clinical Applications of Targeted Radionuclide Therapy in Cancer Control. Chapter 4: Unconjugated radionuclides. Chapter 5: Radionuclide-conjugated cancer-specific vectors: Peptides. Chapter 6: Radionuclide-conjugated cancer-specific vectors: Small Molecules and antibodies. Chapter 7: Radionuclide-conjugated cancer-specific vectors: Nanoparticles. Chapter 8: Introduction to clinical trials and drug development for radionuclide therapies. Chapter 9: Epidemiologic Studies of Cancer Risk among Patients Administered Radionuclides. Chapter 10: Adverse effects of radionuclide therapy. Section III: Radiation Chemistry and Physics. Chapter 11: Radionuclide production. Chapter 12: Radioactivity measurement and traceability. Chapter 13: Instrumentation, calibration, quantitative imaging, and quality control. Section IV: The Future. Chapter 14: Human resources: Multidisciplinary team education, training, and competence. Chapter 15: Theranostics today: Looking backwards to tomorrow.

Über Autor(innen)

Cari (Caridad) Borrás is a certified medical physicist in Washington, DC, USA, where she works as an international consultant and has an adjunct faculty position at the George Washington University School of Medicine and Health Sciences. She obtained a Doctor of Science (Physics) degree from the University of Barcelona, Spain, having done a thesis research project on the dosimetry and embryological effects of Astatine- 211 at Thomas Jefferson University in Philadelphia, PA, USA, as a Fulbright scholar. She has lectured in more than 300 seminars/courses/congresses, many organized by her; authored/contributed around 100 articles and six book chapters and edited two books. She is a Fellow of ACR, AAPM, IOMP, HPS, and IUPESM, and has received awards/recognitions from SEFM, AAPM, IOMP, ALFIM, ACCE, ACR, and ABR.

Michael G. Stabin is a Certified Health Physicist, President of the Radiation Dose Assessment Resource, Inc., living in Kennewick, WA, USA, where he worked for NV5 – Technical Engineering & Consulting Solutions and Hanford Mission Integration Solutions. He was an Associate Professor in the Radiology and Radiological Sciences Department at Vanderbilt University, in Nashville, TN, and a Scientist at the Radiation Internal Dose Information Center of Oak Ridge Institute for Science and Education. He received a Ph.D. in Nuclear Engineering (Health Physics emphasis) from the University of Tennessee, is a member of the HPS and the SNMMI, and is also a Fulbright scholar. He has over 225 publications in the open literature, most on internal dosimetry for nuclear medicine applications, including complete textbooks on health physics and internal dose assessment.