RNA Localization in Eukaryotes and Prokaryotes

Erscheinungsjahr 2026
ISBN: 978-3-032-33883-9
Verlag: Springer

Buch, Englisch, 415 Seiten, Format (B × H): 155 mm x 235 mm

Reihe: Results and Problems in Cell Differentiation

This volume provides a comprehensive overview of RNA localization in both eukaryotic and prokaryotic systems.

In eukaryotic organisms (unicellular, multicellular, animals and plants), the localization and transport of messenger RNA (mRNA) and regulatory small RNAs (sRNA) is a driver of subcellular spatiotemporal complexity and an integral mechanism of cell polarization, polarized cell function, cell fate determination, asymmetric cell division and embryonic patterning. In addition, the localization of organelle-associated RNAs in the vicinity of intracellular organelles is critical for their specific needs and functions. Over the years, it has become clear that despite the absence of a nuclear membrane separating the genetic material from the cytoplasm, prokaryotic organisms can also localize RNA to distinct sites within the cell and use various mechanisms for its trafficking and anchoring.

This book covers all aspects of RNA localization, including different types of localized RNAs, their structure, function, mechanisms of intracellular trafficking, anchoring to different compartments, specific intracellular structures for RNA storage and transport, and new methods to study these processes.

Zielgruppe

Research

Autoren/Hrsg.

Kloc, Malgorzata

Fachgebiete

• Naturwissenschaften Biowissenschaften Molekularbiologie
• Naturwissenschaften Biowissenschaften Zellbiologie
• Naturwissenschaften Biowissenschaften Biochemie (nichtmedizinisch)

Inhaltsverzeichnis

Part I. Overview of RNA Localization and Detection Methods .- Chapter 1. mRNA Localization: Where, Why, and How.- Chapter 2. RNA Localization Mechanisms and Links to Health and Disease.- Chapter 3. RNAs and RNA-Binding Proteins at Areas of Cell Adhesion.- Chapter 4. Perspectives on RNA Localization in the Control of Tissue Biology.- Chapter 5. smFISH-on-Chip: Microfluidic Growth of Candida albicans Coupled with Single-Molecule Fluorescent In Situ Hybridization.- Part II. RNA Localization in Oocytes and Embryos .- Chapter 6. RNA Localization in Oocytes: Mechanisms and Functional Implications.- RNA Odysseys: RNA Localization and Biomolecular Condensates in Germ Cells.- Chapter 7. RNA Odysseys: RNA Localization and Biomolecular Condensates in Germ Cells.- Chapter 8. Oocyte Aging Disrupts Maternal RNA Localization and RNP Organization.- Chapter 9. Regulation of Maternal RNAs during Oogenesis and the Oocyte-to-Embryo Transition.- Chapter 10. RNA Regulation in the Caenorhabditis Elegans Germline and Early Embryo.- Chapter 11. RNA Localization and Local Translation in Early Drosophila embryos.- Chapter 12. RNA Localization in Zebrafish Development: Emerging Approaches Towards Understanding Mechanisms and Functions.- Part III. Post-Transcriptional Regulation and Localized Translation in Somatic Cells and Tissues .- Chapter 13. Analysis of Genes Co-evolved with Igf2bp RNA-Binding Proteins Provides Insights into Post-transcriptional Regulatory Networks.- Chapter 14. Local Translation in the Vertebrate Nervous System.

Über Autor(innen)

Malgorzata Kloc : Prior to completing her postdoctoral training in Canada, Dr. Kloc was a tenured Associate Professor in the Department of Zoology at the University of Warsaw, Poland. She also served as a Research Associate in the Department of Biology at Carleton University in Ottawa, Canada. While completing her postdoctoral training, Dr. Kloc earned the AHFMR Research Award from the University of Calgary and the MRC Biotechnology Training Award from Dalhousie University. She joined the University of Texas M.D. Anderson Cancer Center as a Research Scientist in the Department of Molecular Genetics in 1987, and became an Associate Professor in the Department of Biochemistry and Molecular Biology there in 2006. Dr. Kloc joined the Houston Methodist Research Institute in 2008. Currently, Dr. Kloc is the Weill Cornell Professor of Cell and Molecular Biology at The Houston Methodist Hospital.