Buch, Englisch, Band 1102, 344 Seiten, Format (B × H): 158 mm x 229 mm, Gewicht: 590 g
Reihe: ACS Symposium Series
Buch, Englisch, Band 1102, 344 Seiten, Format (B × H): 158 mm x 229 mm, Gewicht: 590 g
Reihe: ACS Symposium Series
ISBN: 978-0-8412-2765-1
Verlag: American Chemical Society
During the past several years, it has become increasingly clear that carbohydrates, which can be targeted to specific diseases, represent a whole new dimension in drug design. Characterized by a variety of terms - specific recognition, lectins, and molecular diversity, just to cite a few - this new dimension based on carbohydrates essentially has introduced a new language to chemistry, biochemistry, and related disciplines. Vocabulary has been building so fast, in
fact, that most professional chemists (i.e., practitioners who are among the few who work in the area of carbohydrates) may sometimes feel a bit illiterate. This book will help them and many other scientists to better understand the current state of the art and the challenges that remain in
successfully consummating matches of carbohydrate-based drugs and the deadly diseases they target. This book includes preclinical studies and clinical trials of carbohydrate-based drugs in progress as well as analyzing their delivery, biocompatibility, clearance, and metabolic pathways. Further, this book explores a number of other features of carbohydrate drugs and their targets, such as the structure of antibodies with unusually high-affinity for carbohydrates, and protein-glycan interactions
and their inhibitors. Galactomannans and thio-, imino-, nitro-, and aminosugars are particularly considered with respect to their structural and functional impacts. This volume will not only update existing publications on carbohydrate-based drug design but also further shape the emerging data and
thinking in this new area.
Zielgruppe
Academics and professionals in biochemistry
Autoren/Hrsg.
Fachgebiete
- Naturwissenschaften Chemie Chemie Allgemein Pharmazeutische Chemie, Medizinische Chemie
- Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Vorklinische Medizin: Grundlagenfächer Biochemie (med.)
- Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Pharmazie
- Naturwissenschaften Biowissenschaften Biochemie (nichtmedizinisch)
Weitere Infos & Material
Preface
Overview
1. Carbohydrates and Drug Design
Anatole A. Klyosov
Targeted Drug Design
2. Galectin-Targeted Drug Design
Anatole A. Klyosov
Cancer
3. Development of a Galactomannan Polysaccharide as a Vehicle To Improve the Efficacy of Chemotherapeutics
Eliezer Zomer, Anatole A. Klyosov, and David Platt
4. DAVANAT® (GM-CT-01) and Colon Cancer: Preclinical and Clinical (Phase I and II) Studies
Anatole Klyosov, Eliezer Zomer, and David Platt
5. Synthesis and Biological Activity of Galactomycin and DoxoDavanat, New Conjugates of Doxorubicin with D-Galactose and 1,4-?-DGalactomannan
Anna N. Tevyashova, Anatole A. Klyosov, Eugenia N. Olsufyeva, Maria N. Preobrazhenskaya, and Eliezer Zomer
Human Immunodeficiency Virus
6. Carbohydrate-Based Vaccines against HIV/AIDS
Lai-Xi Wang
7. Toward a Carbohydrate-Based HIV-1 Vaccine
Leopold Kong, Jean-Philippe Julien, Daniel Calarese, Christopher Scanlan, Hing-Ken Lee, Pauline Rudd, Chi-Huey Wong, Raymond A. Dwek, Dennis R. Burton, and Ian A. Wilson
Pathogen Management
8. Cationic Polysaccharides in the Treatment of Pathogenic Candida Infections
Avital Mazar Ben-Josef, David Platt, and Eliezer Zomer
New Approaches in Synthesis and Computational Studies
9. Synthetic Methods To Incorporate ?-Linked 2-Amino-2-Deoxy-DGlucopyranoside and 2-Amino-2-Deoxy-D-Galactopyranoside Residues into Glycoconjugate Structures
Robert J. Kerns and Peng Wei
10. Systematic Synthesis of Aminosugars and Their Stereoselective Glycosylation
Jinhua Wang and Cheng-Wei Tom Chang
11. Practical Applications of Computational Studies of the Glycosylation Reaction
Dennis M. Whitfield and Tomoo Nukada
Editor>'s Biography
Indexes
Author Index
Subject Index
