Galectins

1. Auflage 2008
ISBN: 978-0-470-37318-7
Verlag: Wiley

Buch, Englisch, 300 Seiten, Format (B × H): 157 mm x 236 mm, Gewicht: 635 g

The comprehensive guide to the current understanding of galectins and their promising potential in drug design

This is the first book focusing on galectins. It was inspired by topics discussed at the symposium "Galectins: Structures, Functions, and Therapeutic Targets" that was a part of the 234th American Chemical Society meeting in 2007. To help chemists, biochemists, and others understand the challenges inherent in the study of galectins and build on recent advances in the field, the editors have compiled articles from leading experts on galectins and their biomedical applications. Galectins includes:

- An overview of early galectin research
- An explanation of the nature of galectins
- A discussion of the structure and functions of galectins, their ligand specificity and molecular mechanisms of action, and the localization of galectins in the cell
- An exploration of the roles galectins play in tumor growth and cancer, fibrosis, inflammation, and immunity
- A discussion of the effect of galectins on cell migration, angiogenesis, and chemoresistance
- An introduction to new approaches to designing galectin inhibitors

This is the premier reference on galectins for organic, medicinal, carbohydrate, and pharmaceutical chemists, biochemists, molecular and cell biologists, pharmacologists, cancer researchers, and graduate-level students in these disciplines, as well as clinicians and drug developers.

Autoren/Hrsg.

Klyosov, Anatole A

Witczak, Zbigniew J

Platt, David

Fachgebiete

• Naturwissenschaften Biowissenschaften Biochemie (nichtmedizinisch)
• Naturwissenschaften Chemie Organische Chemie Biochemie
• Naturwissenschaften Biowissenschaften Botanik Pflanzenphysiologie, Photosynthese

Inhaltsverzeichnis

Preface vii

Contributors ix

1 Stumbling on Galectins 1
Samuel H. Barondes

2 Galectins and Their Functions in Plain Language 9
Anatole A. Klyosov

3 Understanding Galectin Structure–Function Relationships to Design Effective Antagonists 33
Irina V. Nesmelova, Ruud P.M. Dings, and Kevin H. Mayo

4 Galectins as Regulators of Tumor Growth and Invasion by Targeting Distinct Cell Surface Glycans and Implications for Drug Design 71
Hans-Joachim Gabius and Albert M. Wu

5 Nuclear and Cytoplasmic Localization of Galectin-1 and Galectin-3 and Their Roles in Pre-mRNA Splicing 87
John L. Wang, Kevin C. Haudek, Patricia G. Voss, and Ronald J. Patterson

6 Galectins in Regulation of Inflammation and Immunity 97
Fu-Tong Liu, Daniel K. Hsu, Ri-Yao Yang, Huan-Yuan Chen, and Jun Saegusa

7 Galectins as Danger Signals in Host–Pathogen and Host–Tumor Interactions: New Members of the Growing Group of "Alarmins"? 115
Sachiko Sato and Gabriel A. Rabinovich

8 The Role of Galectins in Organ Fibrosis 147
Neil C. Henderson and Tariq Sethi

9 Galectin-1, Cancer Cell Migration, Angiogenesis, and Chemoresistance 157
Florence Lefranc, Marie Le Mercier, Ve´ronique Mathieu, and Robert Kiss

10 Galectin-3 in the Progression and Metastasis of Colorectal Neoplasia 193
James C. Byrd and Robert S. Bresalier

11 Galectins in Malignant Gliomas: Expression, Functions, and Possible Therapeutic Options 223
Herwig M. Strik and Anna Hoffmann

12 Food-Related Carbohydrate Ligands for Galectins 235
Valeri V. Mossine, Vladislav V. Glinsky, and Thomas P. Mawhinney

Index 271

Über Autor(innen)

Anatole A. Klyosov, PhD, is Chief Scientist and cofounder of Pro-Pharmaceuticals, Inc. He has published more than 290 peer-reviewed articles in scientific journals; authored and edited books on enzymes, carbohydrates, and biotechnology, including Wood-Plastic Composites (Wiley); and holds thirty-nine patents.

Zbigniew J. Witczak, PhD, has extensive industrial and academic experience in carbohydrates. He has published more than ninety research papers and holds six patents in the fields of carbohydrate, medicinal, and biological chemistry. In 2000, Dr. Witczak was awarded the Melville L. Wolfrom Award of the ACS Division of Carbohydrate Chemistry for his outstanding research contribution to carbohydrate chemistry and service to the division.

David Platt, PhD, is Chief Executive Officer and cofounder of Pro-Pharmaceuticals, Inc. He has published peer-reviewed articles and holds many patents, primarily in the field of carbohydrate chemistry. Dr. Klyosov, Dr. Witczak, and Dr. Platt coedited the ACS symposium book Carbohydrate Drug Design.