Nanomaterials as Gene and Nucleic Acid Delivery Platforms

Erscheinungsjahr 2026
ISBN: 978-0-443-27714-6
Verlag: Elsevier Science

Buch, Englisch, 700 Seiten, Format (B × H): 152 mm x 229 mm

Nanomaterials as Gene and Nucleic Acid Delivery Platforms explores the intersection between gene therapy and nanotechnology, assessing the benefits of nanoscale platforms for safe and efficient gene and nucleic acid delivery. Sections address the growing need for alternative gene delivery methods to overcome the limitations and safety concerns associated with conventional viral vectors. Four comprehensive parts provide a holistic overview of the core concepts of gene therapy and delivery; the broad range of nanomaterials available for use as carriers; key approaches, and clinical translation of nanomaterial-based delivery platforms for gene therapy.

This book will be of great use to researchers and academics in the fields of nanomaterials, biomaterials, gene therapy, molecular biology, immunology, and disease therapeutics. This book may also be of interest to clinicians researching novel materials and approaches for therapeutics.

Autoren/Hrsg.

Konwarh, Rocktotpal

Cho, William C.S.

Fachgebiete

• Technische Wissenschaften Maschinenbau | Werkstoffkunde Technische Mechanik | Werkstoffkunde
• Technische Wissenschaften Sonstige Technologien | Angewandte Technik Medizintechnik, Biomedizintechnik
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizin, Gesundheitswesen Medizintechnik, Biomedizintechnik, Medizinische Werkstoffe
• Technische Wissenschaften Verfahrenstechnik | Chemieingenieurwesen | Biotechnologie Biotechnologie

Inhaltsverzeichnis

Part 1: Introduction to Nanomaterials in Gene and Nucleic Acid Delivery
1. Nanomaterials: Basics to biocargo-delivery applications
2. Gene therapy: Principles, prospects, and challenges in viral and non-viral gene delivery stratagems
3. Harnessing nanomaterials in gene delivery, gene therapy and genome engineering- Retrospect and prospects

Part 2: Spectrum of Nanomaterials for Gene Delivery
4. Design, diversity and applications of polymeric nanomaterials in gene delivery
5. Dendrimers and nanostructured hyperbranched polymers in gene delivery
6. Proteins and peptide nanomaterials for gene delivery
7. Polysaccharide based nanomaterials for gene delivery
8. Lipid based nanomaterials in gene delivery
9. Harnessing exosomes for gene delivery
10. Metal based nanomaterials in nucleic acid delivery and therapy
11. Carbon and silica-based nanomaterials for gene delivery
12. Quantum dots as multifunctional gene delivery agents
13. Trigger/stimulus-responsive nanomaterials for gene delivery
14. Viruses: Prospects for nanomedicine and gene delivery

Part 3: Approaches and Considerations in Nanomaterials Mediated Gene Delivery
15. Factors affecting in vitro and ex vivo transfection and in vivo gene delivery using nanomaterials
16. Nanomaterials and gene expression profile modulation
17. Assay approaches for in vitro and in vivo gene expression profiling
18. Nanotechnology, omics science and gene therapy
19. Nanomaterials and facets of epigenetics

Part 4: Key Applications and Clinical Translation
20. Plant genome engineering: Prospects of nanomaterials-based gene delivery
21. Gene delivery using electrospun nanobiomaterials: Implications in tissue engineering and regenerative medicine
22. Nanomaterials for siRNA delivery and the gamut of applications
23. Nanomaterials as CRISPR/Cas delivery platforms for genome editing
24. Harnessing nanomaterials in gene therapy for cancer
25. Nanomaterials for neural-specific gene therapy
26. Nanotechnology in gene delivery for ophthalmic applications
27. Ethics, clinical translation and safety regulations of nanomaterials in gene therapy

Über Autor(innen)

Cho, William C.S.
Dr. William C. Cho, Highly Cited Researchers in 2023 by Clarivate. Dr. Cho has published over 600 SCI peer-reviewed papers; he is the world's top 0.1% most influential scientists in the world.

Konwarh, Rocktotpal
Dr Rocktotpal Konwarh is a Scientist at Baba Kinaram Research Foundation, Mau, India. He completed his PhD in Chemical Sciences from Tezpur University, India, before joining as a DBT Research Associate in Bioinformatics. He was an Institutional Post-Doctoral Fellow in Biomaterial Engineering and Nanomedicine at IIT Guwahati, India. Dr Konwarh has previously been an Assistant Professor at Addis Ababa Science and Technology University, Ethiopia, and a guest faculty member at Dibrugarh University, India, Jimma University, Ethiopia, and Mekelle University, Ethiopia. His research interests include nanomaterials and biopolymeric nanocomposites for biomedical and allied applications, tissue engineering, and targeted therapeutics delivery. He has obtained several research fellowships over the years, including the Canadian Commonwealth visiting research fellowship, University of Guelph, Canada, and the DST-UKIERI project co-investigatorship and post-doctoral visiting research fellowship to University College London, England. Dr Konwarh is an editorial board and review board member of international peer-reviewed journals and author of many highly cited journal articles, as well as a couple of book chapters.