Modulators of Bone Healing

Evolution, Applications, and Future Directions
Erscheinungsjahr 2027
ISBN: 978-981-9274-86-4
Verlag: Springer Nature Singapore

Buch, Englisch, 171 Seiten, Format (B × H): 155 mm x 235 mm

The book sheds new light on the complex process of bone healing by examining both traditional methods and cutting-edge technologies. It offers an in-depth exploration of how various modulators influence bone regeneration. With contributions from renowned experts worldwide, this volume covers everything from the underlying biology to clinical applications.

The chapters cover topics such as the historical development of bone graft substitutes, calcium-based substitutes like hydroxyapatite, bioactive glass, and ceramics, synthetic bone graft materials like chronos granules and stimulan, autografts and allografts, growth factors like BMPs and platelet-rich plasma, stem cells in modern bone healing, osteoconduction concepts, demineralized bone matrix (DBM), advances in nanotechnology for bone healing, 3D-printed scaffolds, biodegradable implants, biochemical properties of bone graft substitutes, the pharmacokinetics of bone healing agents, regulatory frameworks for new bone graft substitutes launch processes.

The book is an essential reference for undergraduate and postgraduate students (MBBS, BSc, MS/DNB), as well as practicing surgeons who seek to deepen their theoretical knowledge and enhance their clinical practice in bone healing, making it valuable for academic exams, viva-voce, and day-to-day patient care.

Zielgruppe

Upper undergraduate

Autoren/Hrsg.

Kumar, Prasoon

Dadra, Ankit

Goni, Vijay

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Chirurgie Orthopädie- und Unfallchirurgie
• Technische Wissenschaften Sonstige Technologien | Angewandte Technik Medizintechnik, Biomedizintechnik
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizin, Gesundheitswesen Medizintechnik, Biomedizintechnik, Medizinische Werkstoffe

Inhaltsverzeichnis

Introduction to Bone Healing.- The Biology of Bone Healing.-Phases of Bone Repair.- Factors Influencing Bone Healing.-Historical Overview of Bone Healing Practices.- Chapter 1: Evolution of Bone Grafting.-Early Practices in Bone Grafting.-Milestones in Bone Graft Development.-Transition from Autografts to Modern Substitutes.-Impact of Technology on Bone Healing Techniques..- Chapter 2: Bone Graft Substitutes.- Historical Development of Bone Graft Substitutes. - Types of Bone Graft Substitutes: Past and Present.-Clinical Applications and Case Studies.-Future Trends in Bone Grafting.- Chapter 3: Calcium-Based Substitutes.- The Discovery and Use of Calcium Sulfate.-Evolution of Calcium Phosphate Cements.-Hydroxyapatite: Historical Development and Applications.-Comparative Analysis of Calcium-Based Substitutes.-Chapter 4: Bioactive Glass and Ceramics. - Inception and Development of Bioactive Glass. - Historical Milestones in Ceramic Materials.- Clinical Applications of Bioactive Glass.-Innovations and Future Directions in Bioactive Materials.- Chapter 5: Synthetic Bone Graft Materials.- Historical Context of Synthetic Bone Grafts.-Development of ChronOS Granules and Polymers.-Introduction and Evolution of Stimulan.- Modern Advances in Synthetic Bone Graft Technology.- Chapter 6: Autografts and Allografts.-Early Use of Autografts: A Historical Perspective.-Evolution of Allografts and the Role of Bone Banks.-Technological Advancements in Graft Processing.-Risk Factors, Complications, and Modern Solutions.-Chapter 7: Growth Factors and Biological Modulators.- The Discovery of Growth Factors in Bone Healing.- Development of BMPs and Their Clinical Use.- Historical Development of Platelet-Rich Plasma (PRP).- Stem Cells and Their Role in Modern Bone Healing.-Chapter 8: The Laurencin Classification. - Introduction to Laurencin’s Classification. - Historical Context and Development. - Application in Bone Tissue Engineering. - Case Studies and Clinical Relevance.-Chapter 9: Osteoconduction, Osteoinduction, and Osteogenesis. - Historical Perspective on Bone Modulation Concepts - Evolution of Osteoconductive Materials. - Mechanisms of Osteoinduction: A Historical Review. - Osteogenesis: From Early Discoveries to Modern Applications.-Chapter 10: Demineralized Bone Matrix (DBM). - The Discovery and Development of DBM. - Evolution in DBM Processing Techniques. - Clinical Applications in Bone Repair. - Efficacy and Outcomes in Modern Orthopedic Surgery.-Chapter 11: Bone Morphogenetic Proteins (BMPs). - The Discovery of BMPs and Their Role in Bone Healing. - Evolution of BMPs in Clinical Practice. - Controversies and Challenges in BMP Use. - BMPs in Spinal Fusion and Fracture Healing.-Chapter 12: Advances in Bone Grafting Technology. -Historical Advances in Bone Grafting Techniques. - Nanotechnology in Bone Healing: From Concept to Application. - 3D-Printed Scaffolds: A New Frontier. - Biodegradable Implants: Evolution and Future Directions.-Chapter 13: Biochemistry and Pharmacological Properties of Bone Healing Materials. - Biochemical Properties of Bone Graft Substitutes. - Pharmacokinetics and Pharmacodynamics of Bone Healing Agents. - Mechanisms of Action: A Molecular Perspective. - Toxicology and Safety Profiles.-Chapter 14: Clinical Outcomes and Challenges. - Evaluating Success in Bone Healing: A Historical Perspective. - Common Complications and Management Over Time. - Long-term Outcomes and Patient Satisfaction. - Case Reports and Lessons from Historical and Modern Studies .-Chapter 15: Regulatory and Ethical Considerations.-Historical Development of Regulatory Frameworks.- Ethical Issues in Early and Modern Bone Tissue Engineering - Quality Control and Safety Standards: Past and Present.-Chapter 16: Process and Regulations for Launching a New Bone Graft Substitute.- Overview of Regulatory Bodies and Requirements.- Preclinical Testing: Biocompatibility and Safety Assessments - Clinical Trials: Phases, Design, and Implementation.- Navigating FDA and CE Mark Approval Processes.- Post-Market Surveillance and Reporting.-Challenges and Strategies for Successful Market Launch.

Über Autor(innen)

Dr.Prasoon Kumar is an Associate Professor in the Department of Orthopaedic Surgery at PGIMER, Chandigarh. He specialises in trauma surgery, with a focus on the hip, elbow, and wrist. He is also an expert in Hip and Knee Arthroplasties. He has 115 publications, including research papers and chapters in reputable journals and books. Dr Kumar has extensive experience in orthobiologics, with ongoing projects related to bone void fillers and substitutes.

Dr. Ankit Dadra is an assistant professor of Orthopedics at PGIMER Chandigarh. He specializes in foot and ankle surgery and is also a skilled trauma surgeon with an interest in arthroplasty. Additionally, he has published several books, has extensive ortho-biologics experience, and is a co-investigator on several ongoing projects in this field.

Professor Vijay G Goniis the Head of the Department of Orthopaedic Surgery at PGIMER, Chandigarh, and a renowned specialist in trauma, spine surgery, and arthroplasty. He has contributed over 150 scientific publications and book chapters to leading orthopaedic literature and has been actively involved in numerous clinical trials and research projects. His distinguished academic career includes several prestigious international fellowships and awards, including theDartmouth-Hitchcock Fellowship, USA, and the Commonwealth Scholarship, UK, along with advanced training and fellowships at various international centres.