Advanced Cancer Therapeutics

Strategies and Technologies for Targeted Drug Delivery
Erscheinungsjahr 2026
ISBN: 978-0-443-44185-1
Verlag: Elsevier Science

Buch, Englisch, 330 Seiten, Format (B × H): 191 mm x 235 mm, Gewicht: 449 g

Advanced Cancer Therapeutics: Strategies and Technologies for Targeted Drug Delivery explores the heterogeneity of tumors and microenvironmental factors that influence cancer treatment and contribute to drug resistance. The book discusses critical elements such as tumor stroma, vasculature, pH, hypoxia, and enzymatic activity that impact therapeutic efficacy. Sections cover advanced drug formulations, including supramolecular systems, metal-organic frameworks, and nanomedicine, focusing on their roles in selective drug delivery for early detection, diagnosis, and treatment of various cancers. In addition, it reviews the current status and future perspectives of these formulations, highlighting their potential to enhance therapeutic outcomes while minimizing side effects.

Readers will also find discussions on the limitations of nanocarriers, along with regulatory and ethical considerations related to anticancer formulations. This resource is invaluable for researchers, clinicians, and students, offering insights into the latest advancements in drug delivery systems.

Autoren/Hrsg.

Kumar, Manish

Jha, Abhishek

Mishra, Brahmeshwar

Fachgebiete

• Wirtschaftswissenschaften Wirtschaftssektoren & Branchen Fertigungsindustrie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Pharmakologie, Toxikologie

Inhaltsverzeichnis

I. UNDERSTANDING THE CANCER
1. Introduction to cancer
2. Current practices in cancer chemotherapy
3. Emerging trend in anticancer drug delivery
4. Cancer therapy depending on tumor stroma
5. Cancer therapy depending on cancer cell respiration: pH and hypoxia
6. Cancer therapy depending on tumor vasculature and EPR effects.
7. Cancer therapy based on extracellular matrix
8. Heterogenicity of cancer and drug resistance
II. STRATEGIES AND TECHNOLOGIES FOR CANCER THERAPY
9. Materials and strategies for advanced anticancer drug delivery
10. Drug Conjugates for anticancer drug delivery
11. Self-assembled supramolecular systems for anticancer drug delivery
12. Advances in metal-organic frameworks for anticancer drug delivery
13. Tumor microenvironment targeted drug delivery systems
14. Advances in dendrimers for anticancer drug delivery
15. Advances in metallic nanoparticles for anticancer drug delivery
16. Advances in polymeric nanoparticles for anticancer drug delivery
17. Advances in lipid-based nanoparticles for anticancer drug delivery
18. Advances in SNEDDS for anticancer drug delivery
19. Advances in nanocrystals for anticancer drug delivery
20. Theranostic nanoparticles for advanced cancer therapy
21. DNA-based nanomaterials for anticancer therapy
22. Nanofibrous scaffolds for cancer management
23. Advances in hydrogel for anticancer drug delivery
24. Advances in inorganic nanocarriers for anticancer drug delivery
25. Microparticles for anticancer drug delivery
26. Microneedles for anticancer drug delivery
27. Implants for anticancer drug delivery
28. Phytomedicine for cancer therapy
29. Enzyme-prodrug as advanced cancer therapeutics
III. CLINICAL STATUS, CHALLENGES AND FUTURE PROSPECTIVES
30. Clinical status of anticancer drug delivery systems
31. Challenges and future prospectives in anticancer drug delivery
32. Regulatory considerations for anticancer drug delivery systems

Über Autor(innen)

Jha, Abhishek
Abhishek Jha is an Assistant Professor at the Department of Pharmaceutics, Dr. D. Y. Patil Institute of Pharmaceutical Sciences and Research, Pune, Maharashtra. He did his Ph.D. and M.Pharm from the Indian Institute of Technology (Banaras Hindu University), India. He has more than 8 years of professional experience in academic research. His field of research includes the development of novel drug delivery technologies for controlled, targeted, and localized delivery of therapeutics for various ailments, including but not limited to cancer, wounds, and inflammatory diseases. So far he has contributed in more than dozens of peer-reviewed articles and more than 25 book chapters published in reputed international journals.

Mishra, Brahmeshwar
Dr. Brahmeshwar Mishra is a Professor of Pharmaceutics at the Indian Institute of Technology (BHU) in Varanasi, with over 40 years of experience in teaching and research. He has served as the Chairman of the Medical Board at IIT (BHU) from June 2012 to 2023. His expertise lies in the formulation of controlled and novel drug delivery systems, including nanoformulations, focusing on bioavailability and pharmacokinetics. He has supervised over 30 doctoral candidates and nearly 100 postgraduate students, publishing around 300 articles, 226 abstracts, 43 book chapters, and holding 3 patents.

He is a leading researcher in drug delivery. He has received numerous awards, including the Best Young Pharmacy Teacher Award and the Pharmacy Excellence Award. Additionally, he has served on editorial boards, traveled internationally for talks, and participated in various academic committees and programs.

Kumar, Manish
Manish Kumar holds the position of Assistant Professor at Amity Institute of Pharmacy in the Greater Noida Campus of Amity University. He completed his doctoral degree at the Indian Institute of Technology (Banaras Hindu University), Varanasi-221005, India. He possesses over 8 years of academic research experience. His research interests are controlled drug delivery systems, nanoemulsions, polymeric nanoparticles, lipid nanoparticles, nanocrystals, nanofibrous scaffolds, hydrogel, and microneedles for treating cancer, wounds, and inflammatory diseases. To date, he has authored over 40 peer-reviewed articles and more than 25 book chapters that have been published in well-known international journals