Advanced Cancer Therapeutics

Strategies and Technologies for Targeted Drug Delivery
Erscheinungsjahr 2026
ISBN: 978-0-443-44185-1
Verlag: Elsevier Science

Buch, Englisch, 860 Seiten, Format (B × H): 191 mm x 235 mm, Gewicht: 449 g

Advanced Cancer Therapeutics: Strategies and Technologies for Targeted Drug Delivery explores the heterogeneity of tumors and microenvironmental factors that influence cancer treatment and contribute to drug resistance. The book discusses critical elements such as tumor stroma, vasculature, pH, hypoxia, and enzymatic activity that impact therapeutic efficacy. Sections cover advanced drug formulations, including supramolecular systems, metal-organic frameworks, and nanomedicine, focusing on their roles in selective drug delivery for early detection, diagnosis, and treatment of various cancers. In addition, it reviews the current status and future perspectives of these formulations, highlighting their potential to enhance therapeutic outcomes while minimizing side effects.

Readers will also find discussions on the limitations of nanocarriers, along with regulatory and ethical considerations related to anticancer formulations. This resource is invaluable for researchers, clinicians, and students, offering insights into the latest advancements in drug delivery systems.

Autoren/Hrsg.

Kumar, Manish

Jha, Abhishek

Mishra, Brahmeshwar

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Pharmakologie, Toxikologie
• Wirtschaftswissenschaften Wirtschaftssektoren & Branchen Fertigungsindustrie Pharmaindustrie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Onkologie, Krebsforschung
• Technische Wissenschaften Verfahrenstechnik | Chemieingenieurwesen | Biotechnologie Pharmazeutische Technologie

Inhaltsverzeichnis

I. UNDERSTANDING THE CANCER
1. Introduction to cancer
2. Current practices in cancer chemotherapy
3. Emerging trend in anticancer drug delivery
4. Cancer therapy depending on tumor stroma
5. Cancer therapy depending on cancer cell respiration: pH and hypoxia
6. Cancer therapy depending on tumor vasculature and EPR effects.
7. Cancer therapy based on extracellular matrix
8. Heterogenicity of cancer and drug resistance
II. STRATEGIES AND TECHNOLOGIES FOR CANCER THERAPY
9. Materials and strategies for advanced anticancer drug delivery
10. Drug Conjugates for anticancer drug delivery
11. Self-assembled supramolecular systems for anticancer drug delivery
12. Advances in metal-organic frameworks for anticancer drug delivery
13. Tumor microenvironment targeted drug delivery systems
14. Advances in dendrimers for anticancer drug delivery
15. Advances in metallic nanoparticles for anticancer drug delivery
16. Advances in polymeric nanoparticles for anticancer drug delivery
17. Advances in lipid-based nanoparticles for anticancer drug delivery
18. Advances in SNEDDS for anticancer drug delivery
19. Advances in nanocrystals for anticancer drug delivery
20. Theranostic nanoparticles for advanced cancer therapy
21. DNA-based nanomaterials for anticancer therapy
22. Nanofibrous scaffolds for cancer management
23. Advances in hydrogel for anticancer drug delivery
24. Advances in inorganic nanocarriers for anticancer drug delivery
25. Microparticles for anticancer drug delivery
26. Microneedles for anticancer drug delivery
27. Implants for anticancer drug delivery
28. Phytomedicine for cancer therapy
29. Enzyme-prodrug as advanced cancer therapeutics
III. CLINICAL STATUS, CHALLENGES AND FUTURE PROSPECTIVES
30. Clinical status of anticancer drug delivery systems
31. Challenges and future prospectives in anticancer drug delivery
32. Regulatory considerations for anticancer drug delivery systems

Über Autor(innen)

Jha, Abhishek
Dr. Jha is an Assistant Professor in the Department of Pharmaceutics at Dr. D. Y. Patil Institute of Pharmaceutical Sciences and Research, Pune, Maharashtra, India. He has more than 8 years of professional experience in academic research, specializing in advanced drug delivery systems, cancer nanomedicine, and 3-D bioprinting. Holding a Ph.D. from the Indian Institute of Technology (BHU), Varanasi, his work focuses on developing targeted therapeutic interventions for cancer, inflammatory lung disorders, and chronic wounds. His research on modern therapeutics leverages deep expertise in extracellular vesicles, nanofibers, polymer chemistry, and microneedle technology. So far, he has contributed to 3 patents, more than 50 peer-reviewed articles and 25 book chapters published in reputed international journals, and edited 2 books. As an academician, he views education as the art of assisting discovery; empowering students to harness their curiosity, transforming foundational concepts into tangible scientific impact.

Kumar, Manish
Dr. Kumar holds the position of Formulation Scientist and Deputy Manager in Research and Development, Cadila Pharmaceutical Limited, Ahmedabad, Gujarat. He completed his doctoral degree at the Indian Institute of Technology (Banaras Hindu University), Varanasi-221005, India. He possesses 6 years of academic research experience. His specialization is Pharmaceutics, working on various drug delivery systems including controlled drug delivery systems, nanoemulsions, polymeric nanoparticles, lipid nanoparticles, nanocrystals, nanofibrous scaffolds, hydrogels, and microneedles for treating cancer, wounds, infections, and inflammatory disorders. To date, he has authored over 50 peer-reviewed articles and about 25 book chapters in well-known international journals. He has 4 patents in his name and edited 2 books. He is working continuously to drive forward cutting-edge research in nanomedicine and drug delivery technologies.

Mishra, Brahmeshwar
Dr. Mishra is a Professor and former Head of the Department of Pharmaceutical Engineering & Technology at the Indian Institute of Technology (Banaras Hindu University). Having earned his B. Pharm, M. Pharm as a Gold Medalist, and Ph.D. from the same institution, he has dedicated over 42 years to advancing pharmaceutical sciences. Throughout his career, Prof. Mishra has established a profound commitment to academic guidance, mentoring over 100 postgraduates, doctoral, and post-doctorate candidates. His research focuses on multiple emulsions, nanomedicine, targeted and rate-controlled drug delivery systems, pharmacokinetics, and bioavailability. This work has yielded over 300 publications, 220 abstracts, 50 book chapters, and 5 patents. With more than 14,000 citations and an h-index exceeding 60, his scholarly impact places him in the top 5% of global researchers as per SciRank Global Database. Beyond his research, Prof. Mishra’s institutional leadership, policy contributions, and enduring dedication to his students continue to anchor and advance pharmaceutical education worldwide.He is a leading researcher in drug delivery. He has received numerous awards, including the Best Young Pharmacy Teacher Award and the Pharmacy Excellence Award. Additionally, he has served on editorial boards, traveled internationally for talks, and participated in various academic committees and programs.