Antimicrobial Resistance

Underlying Mechanisms and Therapeutic Approaches
1. Auflage 2022
ISBN: 978-981-16-3119-1
Verlag: Springer

Buch, Englisch, 605 Seiten, Format (B × H): 160 mm x 241 mm, Gewicht: 1086 g

Antimicrobial resistance (AMR) is a global public health threat that needs immediate attention and action from the scientific community. This book compiles and presents the latest and most important aspects of AMR, including the biology involved, its persistence and spread, and novel approaches to tackle this threat. The book first describes the mechanisms and spread of AMR, and then discusses the various approaches and strategies for combating it. 

Important topics include, microbial pathogenesis, AMR traits and major mechanisms underlying drug-resistance and the emerging strategies and technologies for combating AMR. Emphasis has been given on current developments about natural products including potent phyto-molecules, antimicrobial peptides and endophytes effective against the drug-resistant microbes and target the main drug-resistance determinants (efflux pumps, biofilms, quorum sensing, plasmids, etc.) in these bacterial pathogens. Other exciting topics include applications of nanomaterials in tackling AMR and CRISPR-Cas based precise sequence-specific antimicrobials. 

This informative book is meant for students and researchers in basic and medical microbiology and biotechnology. It is also useful to public health professionals and industry experts involved in AMR research and related drug-designing.

Zielgruppe

Research

Autoren/Hrsg.

Kumar, Vinay

Shriram, Varsha

Paul, Atish

Thakur, Mansee

Fachgebiete

• Naturwissenschaften Biowissenschaften Biowissenschaften Genetik und Genomik (nichtmedizinisch)
• Naturwissenschaften Biowissenschaften Bakteriologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Infektionskrankheiten
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Medizinische Mikrobiologie & Virologie

Inhaltsverzeichnis

Section I The Mechanisms and Spread of Antimicrobial Resistance
1. Antimicrobial resistance: a global problem with limited answersVinay KumarDepartment of Biotechnology,Modern college, Ganeshkhind, Pune, India; &Department of Environmental Sciences, Savitribai Phule Pune University, Ganeshkhind, Pune, IndiaEmail: [e-mail]
2. Antimicrobial resistance in ESKAPE pathogens: an overviewNitaya IndrawattanaDepartment of Microbiology and Immunology,Faculty of Tropical Medicine, Mahidol University,Bangkok, ThailandEmail: [e-mail] PardesiDepartment of Microbiology,Savitribai Phule Pune University, Pune, IndiaEmail: [e-mail]
3. Antimicrobial resistance: from hospital settings to the environmentZulqarnain BalochCollege of Veterinary Medicine,South China Agricultural University,Guangzhou, 510642, ChinaEmail: [e-mail] Bengtsson-PalmeCentre for Antibiotic Resistance Research (CARe),University of Gothenburg, Box 440, SE-40530, Gothenburg, SwedenE-mail: [e-mail]
4. Antimicrobial resistance in agriculture and livestockRonald R MarquardtDepartment of Animal Sciences,The University of Manitoba, Winnipeg MB, CanadaEmail: [e-mail]. L. MehndirattaDepartment of Microbiology,Maulana Azad Medical College,New Delhi, IndiaEmail: [e-mail]
5. Major players involved in spread of antimicrobial resistanceS. Ganesh KumarDepartment of Preventive and Social Medicine,JIPMER, Puducherry, India.E-mail: [e-mail] A. AyukekbongSection for Clinical Microbiology,Redeem Biomedical, Buea, Cameroon; &Metabiota Inc., Nanaimo, BC, CanadaEmail: [e-mail]
6. An overview of molecular mechanisms underlying antimicrobial resistanceV. DuboisLaboratory of Bacteriology, Bordeaux University Hospital, FranceUniversity of Bordeaux, Bordeaux, FranceEmail: [e-mail] HamzeLaboratoire Microbiologie Santé et Environnement (LMSE),Ecole Doctorale des Sciences et de Technologie,Faculté de Santé Publique, Université Libanaise, Tripoli, Lebanon.Email: [e-mail] Khalid BashirAnimal Breeding and Genetics,University of Agriculture, Faisalabad, PakistanEmail:[e-mail]
7. Advances in omics approaches for detecting/characterizing antimicrobial resistancePatrícia M. G. Paiva,Departamento de Bioquímica, Centro de Biociências,Universidade Federal de Pernambuco, Pernambuco, BrazilEmail: [e-mail] P HaysDepartment of Medical Microbiology & Infectious Diseases,Erasmus University Medical Center (Erasmus MC),Rotterdam, The NetherlandsEmail: [e-mail]
8. Alarming drug resistance in urban setupsWei XingKey Laboratory of Aquatic Botany and Watershed Ecology,Wuhan Botanical Garden, Chinese Academy of Sciences,Wuhan 430074, ChinaEmail: [e-mail] PatilDepartment of Environmental Sciences,Savitribai Phule Pune UniversityPune, IndiaEmail: [e-mail] Pratap SinghSchool of Material Science and Technology,Indian Institute of Technology (Banaras Hindu University),Varanasi, IndiaEmail: [e-mail]
Section II Novel and Alternative Approaches for Tackling Antimicrobial Resistance
9. Emerging trends in developing alternative therapies for combating antimicrobial resistanceRaffaele ZarrilliDepartment of Preventive Medical Sciences,Federico II University of NaplesItalyEmail: [e-mail] U. KhanInterdisciplinary Biotechnology Unit,Aligarh Muslim University, Aligarh, IndiaEmail: [e-mail] BoutinDepartment of Emergency Medicine,Nassau University Medical Center,Hempstead Turnpike, East Meadow, NY, United StatesEmail: [e-mail]
10. Novel medicinal plants/ plant derived molecules for combating antimicrobial resistance via re-potentiating the fading antibiotic arsenalReema GabraniDepartment of Biotechnology,Jaypee Institute of Information TechnologyNoida, IndiaEmail: [e-mail].S. EswariDepartment of Biotechnology,National Institute of Technology Raipur, IndiaEmail: [e-mail] KhanDepartment of Biotechnology,School of Engineering and Technology,Sharda University, Greater Noida, IndiaEmail: [e-mail]
11. Potential synthetic treatments for antimicrobial resistant pathogensJaved AliDepartment of Chemical Engineering,Centre for Biological Engineering,Loughborough University, Loughborough,Leicestershire, UKEmail: [e-mail] Cavanagh,Department of Molecular and Structural Biochemistry,North Carolina State University,Raleigh, NC, USA,Email: [e-mail]
12. Application of phytotherapeutics as antibiotic alternatives in animal feedIsabel Blanco-PenedoAnimal Welfare Subprogram, Institute of Agrifood Research and Technology, Girona, SpainEmail: [e-mail] GongGuelph Food Research Centre,Agriculture and Agri-Food Canada,Guelph, CanadaEmail: [e-mail]
13. Antimicrobial peptides as effective agents against drug resistant pathogensBhim Pratap SinghDepartment of Biotechnology,Mizoram University, Aizawl, IndiaEmail: [e-mail] N. SeleemDepartment of Comparative Pathobiology,College of Veterinary Medicine,Purdue University, West Lafayette, USAEmail: [e-mail]
14. Essential oils for resensitizing/combating antimicrobial resistanceAnca MironDepartment of Pharmacognosy,Faculty of Pharmacy, University of Medicine and Pharmacy Grigore T. Popa-Iasi, Universitatii, Iasi, RomaniaEmail: [e-mail] or [e-mail] SimõesLEPABE, Department of Chemical Engineering,Faculty of Engineering,University of Porto, PortugalEmail: [e-mail] BouyahyaaLaboratory of Human Pathologies Biology,Department of Biology, Faculty of SciencesMohammed V University, Rabat, MoroccoE-mail: [e-mail]
15. Plant secondary metabolites for tackling antimicrobial resistanceSwee-Hua Erin LimHealth Sciences Division, Abu Dhabi Women’s College,Higher Colleges of Technology, Abu Dhabi, United Arab EmiratesEmail: [e-mail] Prakash MishraDepartment of Pharmaceutical Chemistry,Hemvati Nandan Bahuguna Garhwal University,Srinagar, Garhwal, IndiaEmail: [e-mail]
16. Microbial secondary metabolites for combating antimicrobial resistanceJolanta SoleckaNational Institute of Public Health – National Institute of Hygiene, Department of Environmental Health and Safety,Warsaw, PolandEmail: [e-mail] WangJiangsu Coinnovation Centre for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, Jiangsu, ChinaE-mail: [e-mail]
17. Phyterapeutics for combating drug efflux pumpsKhondaker M. RahmanInstitute of Pharmaceutical Science,King’s College London, Britannia House, London, UKEmail: [e-mail] FaniDepartment of Biology, University of Florence,Sesto Fiorentino, Florence, ItalyEmail: [e-mail]
18. Plant based plasmid curing agents for combating antimicrobial agentsSimon GibbonsResearch Department of Pharmaceutical and Biological Chemistry,UCL School of Pharmacy,London, UKEmail: [e-mail] SchufflerInstitute of Biotechnology and Drug ResearchErwin-Schrodinger Strabe, GermanyEmail: [e-mail]
19. Anti-quorum sensing agents from natural sources / plantsJohn Thor ArnasonPhytochemistry Laboratory, Department of Biology,University of Ottawa, Ottawa, CanadaEmail: [e-mail] AllendeResearch Group on Quality, Safety and Bioactivity of Plant Foods, Department of Food Science and Technology, Campus de Espinardo, Murcia, SpainEmail: [e-mail]
20. Anti-biofilm agents from natural sources / plantsJens RohloffDepartment of Biology, Norwegian University of Science and Technology, Trondheim, NorwayEmail: [e-mail] KolouchováDepartment of Biotechnology,University of Chemistry and Technology, PragueCzech RepublicEmail: irena [e-mail] LouState Key Laboratory of Food Science and Technology,School of Food Science and Technology, Jiangnan University, Wuxi,PR ChinaEmail: [e-mail]
21. Re-sensitization (drug resistance reversal) of drug resistant microbes with phytotherapeuticsRawaa S Al-kayaliDepartment of Biochemistry and Microbiology, Faculty of Pharmacy, University of Aleppo, Syria.Email: [e-mail]. Ian E. CockEnvironmental Futures Research Institute,Nathan Campus, Griffith University, Nathan,Queensland, Australia.E-mail: [e-mail]
22. Functionalized nanomaterials for combating AMRPedro V. Baptista,UCIBIO, Departamento de Ciências da Vida, Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa, Caparica, PortugalEmail: [e-mail] Martins Department of Microbiology, Moyne Institute ofPreventive Medicine, Schools of Genetics and Microbiology, Trinity College Dublin, University of Dublin, Dublin, IrelandEmail:[e-mail] NagarajanCenter for Research in Infectious Diseases,School of Chemical and Biotechnology,SASTRA Deemed to be University, Thanjavur, IndiaEmail: [e-mail]
23. Exploring in silico approaches for identifying novel antimicrobial agentsT. WeberThe Novo Nordisk Foundation Center for Biosustainability,Technical University of Denmark, Kogle Alle 6, 2970 Hørsholm, Denmark.E-mail:[e-mail] TiwariDepartment of Biochemistry,Central University of RajasthanAjmer, IndiaEmail: [e-mail]
24. CRISPR/Cas9-mediated re-sensitization of antibiotic-resistant microbesDae-Hyuk KweonDepartment of Genetic Engineering and Center for Human Interface Nano Technology, Sungkyunkwan University,Suwon, Republic of KoreaEmail: [e-mail] H. H. NørholmNovo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, 2800, Kongens Lyngby, DenmarkEmail: [e-mail] van HouteEnvironment and Sustainability Institute, Centre for Ecology and Conservation, University of Exeter, Biosciences, Penryn, Cornwall, United Kingdom,European Centre for Environment and Human Health, University of Exeter Medical School, Knowledge Spa, Royal Cornwall Hospital, Truro, Cornwall, United KingdomEmail: [e-mail]

Über Autor(innen)

Dr. Vinay Kumar is an Associate Professor in the Department of Biotechnology, Modern College, Savitribai Phule Pune University, India and a visiting faculty at the Department of Environmental Sciences, S. P. Pune University, India. He obtained his Ph.D. in Biotechnology from S.P. Pune University in 2009. He has published more than 50 peer reviewed research/ review articles, 20 book chapters and has edited 6 books for Springer, Elsevier and Wiley. He has 2500 citations. He is a recipient of the Young Scientist Award of Science and Engineering Board, Government of India. His research interests include antimicrobial resistance in nosocomial and community microbes, elucidation of the molecular mechanisms underlying antimicrobial resistance and combating it with natural products and biofunctionalized nanomaterials.   

Dr. Atish Paul is an Associate Professor and former head at the Department of Pharmacy, Birla Institute of Technology and Science, Pilani (Rajasthan). He completed his Bachelors in Pharmacy from University of Pune (Maharashtra). He pursued M.S. (Pharmaceutical Sciences) and Ph.D. in Natural Products from National Institute of Pharmaceutical Education and Research (NIPER S.A.S Nagar). After completion of his doctorate he joined the research group of Prof. Ikhlas Khan as postdoctoral Research Associate at the National Center for Natural Product Research (University of Mississippi, USA). His area of expertise is Natural Product Chemistry. He has research grants from agencies such as DST-SERB, DST (SEED), DBT etc. He has published several research articles in reputed international journals such as Journal of Medicinal Chemistry, Bioorganic Medicinal Chemistry, Medicinal Chemistry Research, Journal of Chromatography A, and has also contributed 24 Monographs. He is a reviewer for various journals of reputed publishers such as Bentham, Elsevier, etc. and also for funding agencies such as DST SERB, South African Medical Research Council etc.  

Dr. Varsha Shriram has completed her Ph.D. in natural products chemistry and biotechnology from CSIR-National Chemical Laboratory, Pune, India and S.P. Pune University, Pune, India. She is currently working as an Associate Professor for Plant Sciences at Prof. Ramkrishna More College, Akurdi (S.P. Pune University), Pune, India. She has published more than 30 peer-reviewed research/review articles and is on reviewer board for reputed journals and funding agencies like Science and Engineering Research Board (SERB), Government of India. Her areas of interest include medicinal plants, isolation and identification of phytochemicals, and their activity studies including anticancer and antimicrobial, the antimicrobial resistance in nosocomial and community microbes and combating it with phytochemicals and nanomaterials. She has completed extramural research projects in these and allied areas.  

Dr. Mansee Thakur is a Gold Medalist during her MSc at Pt. R. S. S. University, Raipur and obtained her PhD in Biotechnology fromUniversity of Raipur, India in 2007. She is currently working as a Professor and Director, Mahatma Gandhi Missions Institute of Health Sciences, MGM School of Biomedical Sciences, Navi Mumbai. She has published more than 30 peer-reviewed research articles and has filed 4 patents. She is a recipient of the Young Scientist Award of the Chhattisgarh State. Her areas of research include natural products and their antimicrobial potencies, molecular biology and toxicity studies. She has completed many extra-mural research projects and guided students for their Masters and Doctoral studies. She is an active reviewer/editor for books and journals.