Redefining the Microrna Functionality in Cancer Diagnostics and Therapeutics

Erscheinungsjahr 2027
ISBN: 978-0-443-45952-8
Verlag: Elsevier Science

Buch, Englisch, 330 Seiten, Format (B × H): 191 mm x 235 mm, Gewicht: 449 g

Redefining the microRNA functionality in cancer diagnostics and therapeutics is an authoritative volume that explores the pivotal role of microRNAs (miRNAs) in precision oncology. It integrates fundamental biology, cutting-edge bioinformatics, and translational research, providing a comprehensive overview of miRNA mechanisms, regulation, and clinical applications. The book emphasizes technological advances such as single-cell profiling, CRISPR engineering, and AI-driven diagnostics. The content covers miRNA biology, multi-omics integration, innovative therapeutic strategies, and clinical translation, including liquid biopsies and biosensors. It also addresses industry and regulatory aspects, offering practical insights for translating research into clinical and commercial settings. Rich with case studies and visual aids, the book bridges the gap between bench research and bedside implementation. For the academic audience, this book offers a multidisciplinary resource that enhances understanding of miRNA-based diagnostics and therapeutics, fostering innovation and accelerating clinical adoption in cancer care.

Autoren/Hrsg.

Kumar, Vivek

Shukla, Rohit

Chaudhary, Amit

Fachgebiete

• Naturwissenschaften Biowissenschaften Biowissenschaften

Inhaltsverzeichnis

1. miRNA Biology Reexplored: Beyond Traditional Functions
2. Epigenetic and Environmental Modulation of miRNAs in Cancer
3. Integration of miRNAs with Multi-Omics Data: A Systems Biology Approach
4. Machine Learning and AI Models for miRNA-Based Diagnostics
5. Single-Cell miRNA Profiling: Tools and Applications
6. miRNA Engineering: CRISPR/Cas Systems, Synthetic Circuits, and RNA Devices
7. Theranostic miRNAs: Dual Role in Imaging and Therapy
8. Clinical Translation: Liquid Biopsies, Trials, and Companion Diagnostics
9. miRNA-Based Biosensors and Point-of-Care Technologies
10. Immuno-Oncology and miRNA Crosstalk in the Tumor Microenvironment
11. AI-Powered Drug Discovery and Repurposing via miRNA Signatures
12. Intellectual Property and Patent Landscape in miRNA Diagnostics
13. Case Studies: Ovarian, Breast, and Brain Tumors—From Bench to Bedside
14. MiRNA Drugs in Clinical Practice
15. Current challenges, limitations, and regulatory hurdles in translating miRNA research into clinical practice

Über Autor(innen)

Kumar, Vivek
Dr. Vivek Kumar is a postdoctoral researcher at the University of South Florida, specializing in the study of the human microbiome, epigenetic mechanisms, and neurodegeneration. His research focuses on multi-omics integration to identify biomarkers for cognitive impairment and Alzheimer’s disease, utilizing advanced statistical modeling and machine learning for host-microbe interaction analysis through saliva-based diagnostics. Previously, he completed a postdoctoral fellowship at AIIMS Patna, contributing to translational cancer research on epigenetic dysregulation of microRNAs in triple-negative breast cancer. He earned his Ph.D. in Biotechnology from Motilal Nehru National Institute of Technology, India, with a focus on epigenetics and non-coding RNAs in ovarian cancer. His expertise includes microbiome profiling, methylation analysis, miRNA quantification, and systems biology approaches. Dr. Kumar has extensive experience with molecular techniques and bioinformatics tools, and he has published numerous peer-reviewed articles. He also serves as a reviewer for leading journals in oncology, bioinformatics, and molecular diagnostics.

Shukla, Rohit
Dr. Rohit Shukla holds a Ph.D. from Jaypee University of Information Technology, India, and is currently a Postdoctoral Research Fellow at the University of South Florida. His research focuses on metagenomics and multi-omics studies of microbiome-host interactions related to Alzheimer’s disease, exploring biomarkers and therapeutic targets through genome sequencing, taxonomic profiling, and microbial causal inference. He also works in transcriptomics, miRNA analysis, single-cell, and epigenetics. His Ph.D. research involved annotating hypothetical proteins, identifying biomarker genes using machine learning, and in silico drug target discovery. Skilled in tools like QIIME2, Kraken2, and Galaxy, he is developing diagnostic biomarkers and saliva-based early detection assays for Alzheimer’s. Rohit has published extensively and reviews for reputable journals. With a multidisciplinary background, he aims to advance precision diagnostics and therapeutic strategies through systems biology and integrative omics approaches.

Chaudhary, Amit
Dr. Amit Chaudhary is a Postdoctoral Scholar at the University of Alabama at Birmingham, working on deorphanizing G-protein-coupled receptors (GPCRs). His research interests include genomics, structural bioinformatics, and biophysics. Previously, he was a postdoctoral fellow at IIT Bombay in the Polymer Simulation and Characterization Lab. He earned his Ph.D. in Biotechnology from Motilal Nehru National Institute of Technology, Allahabad, and holds an M.Tech. in Bioinformatics from IIIT Allahabad, as well as a Bachelor of Pharmacy from the United Institute of Pharmacy, Allahabad. His expertise spans transcriptomics, molecular modeling, docking, molecular dynamics, phylogenetics, and protein-gene interaction analysis. Dr. Chaudhary's work focuses on functional and pathway analysis of proteins and genes, aiming to advance understanding in molecular biology and computational biochemistry.