Advances in Design of Microbial Cell Factories

Erscheinungsjahr 2027
ISBN: 978-0-443-49084-2
Verlag: Elsevier Science

Buch, Englisch, 300 Seiten, Format (B × H): 191 mm x 235 mm

Advances in Design of Microbial Cell Factories presents a comprehensive overview of the latest innovations in engineering microbial platforms for sustainable production of biochemicals, biofuels, pharmaceuticals, and industrial enzymes. The book opens with an introduction and historical overview of microbial cell factories, followed by a wide spectrum of topics including omics-driven design and engineering of microbial cell factories, metabolic flux analysis, genome-scale metabolic modeling, modular pathway engineering, biosensors, adaptive laboratory evolution, protein engineering and enzyme optimization in microbial hosts. The latest developments in designing bacterial, yeast, mold and microalagae cell factories are covered, as well as current challenges to be considered in scale-up of microbial cell factories. Chapters are supported by real-world case studies that demonstrate translation from laboratory research to industrial-scale applications across a diverse range of sectors. This reference consolidates foundational knowledge with emerging technologies, equipping researchers, graduate students, and industry professionals with practical insights to accelerate their own development of microbial platforms.

Autoren/Hrsg.

Lahiri, Dibyajit

Harzevili, Farshad Darvishi

Fachgebiete

• Naturwissenschaften Biowissenschaften Zellbiologie
• Naturwissenschaften Biowissenschaften Mikrobiologie
• Technische Wissenschaften Verfahrenstechnik | Chemieingenieurwesen | Biotechnologie Verfahrenstechnik, Chemieingenieurwesen

Inhaltsverzeichnis

1. Introduction to microbial cell factories
2. X-omics for design of microbial cell factories
3. Omics-guided engineering of microbial metabolism
4. Omics-guided engineering of microbial metabolism, modular pathway and protein engineering
5. Metabolic Flux Analysis
6. Genome-scale metabolic modeling
7. Modular pathway engineering
8. Promoter libraries, RBS tuning, and genetic circuits
9. Biosensors and logic gates in microbial cells
10. Adaptive laboratory evolution for trait enhancement
11. Protein engineering
12. Enzyme optimization in microbial hosts
13. Recent advances in design of bacterial cell factories
14. Progresses in design of yeast cell factories
15. New insights in design of mold cell factories
16. Developments in design of microalgae cell factories
17. Fermentation scale-up challenges, multiple stress factors in strain engineering, techno-economic comparative analysis
18. AI-assisted design of microbial cell factories

Über Autor(innen)

Harzevili, Farshad Darvishi
Farshad Darvishi Harzevili is Full Professor at Alzahra University, Iran. He is mainly interested in the biotechnological and environmental applications of yeasts to the production of valuable products. He is also interested in metabolic engineering and synthetic biology of yeasts.
Dr. Darvishi has published a number of books with various publishers including Springer and Taylor and Francis, and also serves as series editor for the Elsevier book series "Developments in Microbial Cell Factories: From Design to Commercial Production".

Lahiri, Dibyajit
Dibyajit Lahiri, PhD, is Associate Professor in the Department of Biotechnology, University of Engineering & Management, Kolkata. His research focuses on biofilm formation on human prostheses and its inhibition through phytochemical and nanocompound interventions, with particular interest in the molecular mechanisms by which natural compounds disrupt biofilm integrity. His work also encompasses computational drug development using bioinformatics approaches. Dr. Lahiri has authored over numerous publications, has edited academic volumes in his field, and serves as Associate Editor for multiple international peer-reviewed journals.