Mathematical and Statistical Methods for Genetic Analysis

2. Auflage 2002
ISBN: 978-0-387-95389-2
Verlag: Springer

Buch, Englisch, 370 Seiten, Format (B × H): 160 mm x 241 mm, Gewicht: 1610 g

Reihe: Statistics for Biology and Health

During the past decade, geneticists have cloned scores of Mendelian disease genes and constructed a rough draft of the entire human genome. The unprecedented insights into human disease and evolution offered by mapping, cloning, and sequencing will transform medicine and agriculture. This revolution depends vitally on the contributions of applied mathematicians, statisticians, and computer scientists. Mathematical and Statistical Methods for Genetic Analysis is written to equip students in the mathematical sciences to understand and model the epidemiological and experimental data encountered in genetics research. Mathematical, statistical, and computational principles relevant to this task are developed hand in hand with applications to population genetics, gene mapping, risk prediction, testing of epidemiological hypotheses, molecular evolution, and DNA sequence analysis. Many specialized topics are covered that are currently accessible only in journal articles. This second edition expands the original edition by over 100 pages and includes new material on DNA sequence analysis, diffusion processes, binding domain identification, Bayesian estimation of haplotype frequencies, case-control association studies, the gamete competition model, QTL mapping and factor analysis, the Lander-Green-Kruglyak algorithm of pedigree analysis, and codon and rate variation models in molecular phylogeny. Sprinkled throughout the chapters are many new problems.

Zielgruppe

Research

Autoren/Hrsg.

Lange, Kenneth

Fachgebiete

• Interdisziplinäres Wissenschaften Wissenschaften: Forschung und Information Datenanalyse, Datenverarbeitung
• Mathematik | Informatik Mathematik Stochastik Mathematische Statistik
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Vorklinische Medizin: Grundlagenfächer Humangenetik
• Naturwissenschaften Biowissenschaften Molekularbiologie
• Naturwissenschaften Biowissenschaften Tierkunde / Zoologie Tiergenetik, Reproduktion
• Naturwissenschaften Biowissenschaften Angewandte Biologie Biomathematik
• Naturwissenschaften Biowissenschaften Botanik Pflanzenreproduktion, Verbreitung, Genetik
• Naturwissenschaften Biowissenschaften Biowissenschaften Genetik und Genomik (nichtmedizinisch)
• Mathematik | Informatik Mathematik Stochastik Wahrscheinlichkeitsrechnung

Inhaltsverzeichnis

Basic Principles of Population Genetics.- Counting Methods and the EM Algorithm.- Newton's Method and Scoring.- Hypothesis Testing and Categorical Data.- Genetic Identity Coefficients.- Applications of Identity Coefficients.- Computation of Mendelian Likelihoods.- The Polygenic Model.- Descent Graph Models.- Molecular Phylogeny.- Radiation Hybrid Mapping.- Models of Recombination.- Sequence Analysis.- Poisson Approximation.- Diffusion Processes.