Insulin-like Growth Factors and Cancer

From Basic Biology to Therapeutics
1. Auflage 2011
ISBN: 978-1-4614-0597-9
Verlag: Springer

Buch, Englisch, 284 Seiten, Format (B × H): 160 mm x 241 mm, Gewicht: 611 g

Reihe: Cancer Drug Discovery and Development

The book will detail the history, successes, and failures of targeted therapies for cancer, with a particular focus on IGF systems and cancer.

Zielgruppe

Research

Autoren/Hrsg.

LeRoith, Derek

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Pharmakologie, Toxikologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Onkologie, Krebsforschung
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Pharmazie

Inhaltsverzeichnis

Preface.- Epidemiology of IGF-1 and Cancer.- Aging and Cancer: The IGF-I Connection.- Obesity, Type 2 Diabetes and Cancer.- IGF System and Breast Cancer.- The Role of Insulin-Like Growth Factor Signaling in Prostate Cancer Development and Progression.- Mouse Models of IGF-1 Deficiency.- Insulin-like Growth Factor Signaling in Pediatric Sarcomas.- Cancer Genes, Tumor Suppressors, and Regulation of IGF-1R Expression in Cancer.- Mouse Models of IGF-1R and Cancer.- Targeting the Insulin-Like Growth Factor-I Receptor in Cancer Therapy.- Targeting Insulin-like Growth Factor (IGF-1R) and Insulin Receptor Signaling by Tyrosine Kinase Inhibitors in Cancer.- Calories and Cancer: The Role of Insulin-like Growth Factor.- Cancer Cell Metabolism.- Overlaps between the Insulin and IGF-1R and Cancer.- Index