Buch, Englisch, 340 Seiten, Paperback, Format (B × H): 155 mm x 235 mm, Gewicht: 575 g
Proceedings of the First International Symposium
Buch, Englisch, 340 Seiten, Paperback, Format (B × H): 155 mm x 235 mm, Gewicht: 575 g
ISBN: 978-1-4613-9210-1
Verlag: Springer
Zielgruppe
Research
Autoren/Hrsg.
Weitere Infos & Material
Symposium Presentation: Diethylstilbestrol (DES) Syndrome: Present Status of Animal and Human Studies.- 1. Sex Hormones and Carcinogenesis.- Introduction: Androgen Receptors and Regulation of Androgen Action in Normal and Abnormal Cells.- 1 The Conjoint Actions of Androgens and Estrogens in the Induction of Proliferative Lesions in the Rat Prostate.- 2 Enhancement of Prostate Carcinogenesis in Rats by Testosterone and Prolactin.- 3 Hormonal Carcinogenesis in Syrian Hamsters: A Hypothesis Involving Glutathione S-Transferase Regulation.- 2. Hormones, Cell Proliferation, and Carcinogenesis.- Introduction: Current Concepts of Sex Hormone Action (An Overview).- 4 Control of Uterine Epithelial Growth and Differentiation: Implications for Estrogen-Associated Neoplasia.- 5 A Novel Protein Kinase Activity Identified from Human Breast Cancer Cell Lines.- 6 Estrous Cycle Modification of Rat Mammary Carcinoma Induction.- 7 Hormones, Cell Proliferation, and Mammary Carcinogenesis.- 3. Estrogen Metabolism and Carcinogenicity.- Introduction: Factors Influencing the Metabolism and Action of Estradiol.- 8 Interactions of Carcinogenic Estrogens with Microtubular Proteins.- 9 Differential Interactions of Estradiol Metabolites with the Estrogen Receptor: Genomic Consequences and Tumorigenesis.- 10 Oxidation of Estrogens and Other Steroids by Cytochrome P-450 Enzymes: Relevance to Tumorigenesis.- 11 Metabolism of Moxestrol in the Hamster Kidney: Significance for Estrogen Carcinogenesis.- 4. Hormones and Tumor Promotion.- Introduction: Inhibition of Tumor Promotion by Antihormonal Agents.- 12 Sexual Dimorphism of Hepatic Steroid Metabolism and Its Significance for Chemical Hepatocarcinogenesis.- 13 Growth Stimulation and Tumor Promotion in Rat Liver by Ethynyl Estradiol and Other Estrogens.- 14 Growth Factors in Murine Mammary Adenocarcinomas Induced by Progestins.- 15 The Influence of Steroid Hormones and Antihormones on the Growth and Differentiation of Normal Human Breast Cells in Culture.- 5. Growth Factors and Oncogenes.- Introduction: Molecular Mechanisms of Hormonal Carcinogenesis.- 16 The v-raf and Ha-ras Oncogenes Inhibit Transcription from the Beta-Casein Gene Promoter by Suppression of a Mammary Gland Specific Transcription Factor.- 17 Functional Aspects of EGF-Like Peptides in Ovarian-Steroid Responsive Organs.- 18 Androgen Regulation of Growth Factor and Early Growth Response Gene Expression in Hamster DDT1-MF2 and Human Prostate LNCAP Cells.- 19 Estrogen Regulation of Protooncogene Expression.- 6. Carcinogenesis Risk Assessment of Sex Hormones.- Introduction: Receptor-Mediated Carcinogenesis: Implications for Carcinogenic Risk of Sex Hormones.- 20 Endogenous Estrogen and Progesterone as the Major Determinants of Breast Cancer Risk: Prospects for Control by ‘Natural’ and ‘Technological’ Means.- 21 Synthetic Estrogens and Liver Cancer: Risk Analysis of Animal and Human Data.- 22 Carcinogenic Risk Assessment of Steroid Hormone Exposure in Relation to Prostate Cancer Risk.- Closing Remarks.- Hormonal Carcinogenesis—Future Perspectives.- Communications.- Cytogenetic Changes in Renal Neoplasms and During Estrogen-Induced Renal Tumorigenesis in Hamsters.- Pituitary Regulation of Sex-Differentiated Promotion of Rat Liver Carcinogenesis.- Modulation of Estrogen Metabolism by Inducers of P-4501A2: Possible Application to the Chemoprevention of Breast Cancer.- Estrogen Metabolism in Subcellular Preparations and Tissue Culture of Syrian Hamster Liver and Kidney.- Hormonal Regulation of Plasminogen Activation in the Human Endometrium.- Your Research—Our Lives.- Prostaglandin H Synthase Peroxidase Catalyzed Metabolism of Estrogens in Syrian Hamster and Rabbit Kidney.- Peroxidative Metabolism of Diethylestilbestrol in Ram Seminal Vesicle Cell Cultures: An In-Vitro Model for Studies of Estrogen-Induced Genotoxicity.- In Vivo Effects of Progesterone on Human Breast 17?-Dehydrogenase and Epithelial Cells Mitotic Activities.- DNA Adduct Profiles in Hamster Kidney Following Chronic Exposure to Various Carcinogenic and Noncarcinogenic Estrogens.- Hormone-Dependent Activation of c-Ki-ras in N-Methyl-N-Nitrosourea (MNU)-Induced Mouse Mammary Tumors.- Growth Hormone Regulation of the c-myc Gene During Sex-Differentiated Rat Liver Carcinogenesis.- Fetal Stromal Cells Produce a TGF that Elicits Hyperplasia in Adult Mammary Epithelium.- Induction of Catechol Estrogen Formation by Indole-3-Carbinol.- Cytochrome P-450 Mediated Activation and Irreversible Binding of Tamoxifen to Rat and Human Liver Proteins.- Neonatal Diethylstilbestrol Prevents Spontaneously Developing Mammary Tumors.- Hormone-Dependent Uterine Adenocarcinoma Following Developmental Treatment with Diethylstilbestrol: A Murine Model for Hormonal Carcinogenesis.- Effects of Steroidal and Stilbene Estrogens and Their Peroxidative Metabolites on Microtubular Proteins.- Properties of Micronuclei Induced by Various Estrogens in Two Different Mammalian Cell Systems.- High-Performance Liquid Chromatography Method for the Separation of Potential Metabolites of Estradiol.- Ovarian Hormones Enhance the Carcinogenic Activity of 2,3,7,8-TCDD in Rats.