Buch, Englisch, Format (B × H): 155 mm x 235 mm
Buch, Englisch, Format (B × H): 155 mm x 235 mm
Reihe: Handbook of Experimental Pharmacology
ISBN: 978-3-032-46050-9
Verlag: Springer
This volume aims to provide a comprehensive, authoritative, and cutting-edge treatise on the revolutionary technology of Proteolysis Targeting Chimeras (PROTACs). By harnessing the cell's innate ubiquitin -proteasome system, PROTAC technology achieves targeted degradation of proteins previously considered 'undruggable', thereby profoundly expanding the frontiers of drug discovery and representing a fundamental shift in the paradigm of targeted therapy. The scope of this work will systematically traverse the entire spectrum of PROTAC development, from theoretical foundations to clinical translation. Key areas of focus include: Molecular Basis and Mechanism, Through Tools and Translation, Into Depth and Optimization, Toward the Future and Beyond.
In summary, this special volume comprehensively covers the entire PROTAC ecosystem—from fundamental biology and cutting-edge design strategies to practical development tools, clinical translation hurdles, and emerging next-generation technologies. It not only captures the current state of the science but also critically examines the challenges and opportunities that will define the future of targeted protein degradation.
Zielgruppe
Research
Autoren/Hrsg.
Fachgebiete
- Naturwissenschaften Chemie Chemie Allgemein Pharmazeutische Chemie, Medizinische Chemie
- Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Pharmakologie, Toxikologie
- Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Onkologie, Krebsforschung
Weitere Infos & Material
Introduction of Targeted Protein Degradation.- The Ubiquitin Proteasome System The Cell's Natural Destroyer.- PROTACs Proteolysis Targeting Chimeras Design and Mechanism.- PROTAC as a Potential Toolbox for the Discovery of New Targets and Drugs.- Techniques for Accelerating the Understanding of PROTAC-Based Ternary Complex.- Highthroughput Screen for Candidate PROTAC Identification.- The Exploration for the Bioavailability of PROTAC.- Multidimensional Optimization of PROTAC Design.- Expanding the E3 Ligase Landscape From Small Molecule to Biological Targeted Protein Degradation.- The delivery strategies of PROTAC.- Beyond PROTACs: Conditional Technologies and New Frontiers.- The Future of Targeted Degradation Outlook and Unanswered Questions.
