Surface-Enhanced Raman Spectroscopy for Cancer Diagnostics

Fundamental Principles and Applications
Erscheinungsjahr 2026
ISBN: 978-0-443-40411-5
Verlag: Elsevier - Health Sciences Division

Buch, Englisch, 520 Seiten, Format (B × H): 191 mm x 235 mm, Gewicht: 450 g

Reihe: Micro and Nano Technologies

Surface-Enhanced Raman Spectroscopy for Cancer Diagnostics: Fundamental Principles and Applications bridges the gap between theory and practice, offering a detailed overview of surface-enhanced Raman spectroscopy (SERS) principles and its use in detecting cancer biomarkers. Starting with the basics of Raman spectroscopy and SERS, the book explores the relevance, design strategies, and applications of SERS in early cancer detection and treatment. It highlights the impact of nanotechnology on SERS, including the development of substrates and nanoprobes for both label-free and labeled detection. Following chapters discuss SERS immunoassays, imaging, and spectroscopic technologies for detecting cancer biomarkers.

Finally, the book explores non-invasive detection methods, multimodal imaging techniques, and the integration of artificial intelligence in SERS for test analysis, making it a valuable resource for researchers interested in the application of nanotechnologies in the field of cancer diagnostics and treatment.

Autoren/Hrsg.

Lin, Linley Li

Bhaskar, Seemesh

Bonyár, Attila

Thomas, Sabu

Fachgebiete

• Technische Wissenschaften Maschinenbau | Werkstoffkunde Technische Mechanik | Werkstoffkunde

Inhaltsverzeichnis

1. Introduction to Raman Spectroscopy and Surface-Enhanced Raman Spectroscopy (SERS)
2. SERS: Relevance, Design Strategies and Applications
3. Cancer: relevance of early diagnostics and treatment
4. Role of Nanotechnology in Cancer Diagnostics
5. Advancement of Nanotechnology in SERS developments: substrates and nanoprobes for label-free and labelled detection
6. SERS Immunoassays: Principles and design strategies
7. SERS-based imaging and spectroscopic technologies for cancer biomarker detection
8. SERS for pathogen detection
9. SERS-based Detection of non-invasive Cancer Biomarker: sweat, saliva, sputum, urine, and volatile organic compounds (VOCs)
10. SERS-based Detection of invasive Cancer Biomarker: nucleic acids, proteins, lipids, metabolites
11. SERS needle patch for skin cancer diagnosis
12. SERS-based Multimodal Imaging Techniques
13. SERS for intraoperative surgery guidance and tumor boundary detection
14. Deep SERS imaging technologies for non-invasive lesion diagnostics
15. Artificial Intelligence for SERS: advances in Point-of-Care test analysis
16. SERS for cancer diagnostics in clinical samples: Challenges and opportunities
17. Emerging Trends in SERS Instrumentation and Signal Enhancement Techniques
18. Biocompatibility and Biosafety Considerations in SERS Probe Design
19. Tumor detection, Cancer screening, Diagnostics assays
20. Concluding remarks: Clinical Translation and Regulatory Considerations of SERS for cancer diagnostics

Über Autor(innen)

Bhaskar, Seemesh
Dr. Seemesh Bhaskar is a Carl R. Woese Institute for Genomic Biology (IGB) fellow at the University of Illinois at Urbana-Champaign (UIUC), USA. He completed his Ph.D. from STAR Lab, Central Research Instruments Facility (CRIF), SSSIHL, and postdoctoral studies from NanoStructured Materials (NSM) group, Indian Institute of Technology (IIT), Bombay. He has pursued research internships at SASTRA University and the Indian Institute of Science, Bangalore, as part of the DST-Inspire program. He is the recipient of the prestigious DST-Inspire scholarship & fellowship, AWSAR, K. V. Rao Scientific Society (KVRSS), Young Achiever, M.Sc. Chemistry Gold medal and All-rounder Gold medal awards. His research work focuses on building effective nano-engineering protocols for photo-plasmonic biosensing at advanced interfaces comprising sustainable bioinspired polymeric hybrids.

Thomas, Sabu
Professor Sabu Thomas is currently an Emeritus Professor of Mahatma Gandhi University, Kottayam, Kerala, India. He was the former Vice Chancellor of Mahatma Gandhi University. He is a Senior Professor of Christ University, Bangalore, India. He is also a visiting Professor at the Department of Chemical Sciences, University of Johannesburg, Johannesburg, South Africa, Department of Chemical Engineering, Faculty of Engineering, Chulalongkorn University, Bangkok, Thailand, and an Adjunct Faculty in the Department of Polymer and Process Engineering, IIT Roorkee, India. He is the Chairman of the TrEST Research Park, Trivandrum, Kerala, India. The H index of Professor Thomas is 163 and he has more than 133,000 citations

Bonyár, Attila
Dr. Attila Bonyár is an associate professor and head of the Nanotechnology laboratory at the Department of Electronics Technology, Faculty of Electronics Engineering and Informatics, Budapest University of Technology and Economics, Hungary. He has two M.Sc. degrees in electrical engineering (2009) and biomedical engineering (2011), a Ph.D. (2014), and habilitation (2021) in electrical engineering. His current research activities are focused on the development of optical biosensor technologies utilizing plasmonics, low-dimensional nanomaterials, nanocomposites and nanometrology. He was elected to serve in the Hungarian Academy of Sciences (HAS) Electron Devices and Electronics Technology Scientific Committee for two terms (in 2017 and in 2021). He is the chair for IEEE NTC Nanopackaging Technical Committee (since 2022, co-chair since 2020) and actively serves in many other international committees in elected/volunteer positions.

Lin, Linley Li
Dr. Linley Li Lin is currently an Assistant Professor at Shanghai Jiao Tong University (SJTU), China. She received her B.S. and Ph.D. degrees from SJTU and worked as a postdoctoral fellow at the University of Illinois at Urbana-Champaign, USA, and SJTU. During her PhD and Postdoctoral research, she was one of the principal researchers of GERTs - a novel SERS nanotag with ultra-high sensitivity, uniformity, and photostability. Her current research interests include deep Raman techniques, surface-enhanced Raman scattering bioimaging, and Raman spectroscopic platform to study biomaterial interfaces.