Buch, Englisch, 71 Seiten, Paperback, Format (B × H): 155 mm x 235 mm, Gewicht: 154 g
Reihe: Springer Theses
Buch, Englisch, 71 Seiten, Paperback, Format (B × H): 155 mm x 235 mm, Gewicht: 154 g
Reihe: Springer Theses
ISBN: 978-3-030-09104-0
Verlag: Springer International Publishing
Cancer has become a significant threat to human health with more than eight million deaths each year, and novel methods for cancer management to improve patients’ overall survival are urgently needed. The developed multifunctional GNS nanoprobe with tip-enhanced plasmonics in the near-infrared region can be combined with (1) surface-enhanced Raman spectroscopy (SERS), (2) two-photon photoluminescence (TPL), (3) X-ray computed tomography (CT), (4) magnetic resonance imaging (MRI), (5) positron emission tomography (PET), and (6) photothermal therapy (PTT) for cancer imaging and treatment. The ability of the GNS nanoprobe to detect submillimeter intracranial brain tumors was demonstrated using PET scan – a superior non-invasive imaging modality – in a mouse animal model. In addition, delayed rechallenge with repeated cancer cell injection in cured mice did not lead to new tumor formation, indicating generation of a memorized immune response to cancer.
The biocompatible gold nanostars with superior capabilities for cancer imaging and treatment have great potential for translational medicine applications.
Zielgruppe
Research
Autoren/Hrsg.
Fachgebiete
- Naturwissenschaften Chemie Chemie Allgemein Pharmazeutische Chemie, Medizinische Chemie
- Technische Wissenschaften Technik Allgemein Nanotechnologie
- Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Onkologie, Krebsforschung
- Technische Wissenschaften Maschinenbau | Werkstoffkunde Technische Mechanik | Werkstoffkunde Materialwissenschaft: Biomaterialien, Nanomaterialien, Kohlenstoff
- Naturwissenschaften Chemie Analytische Chemie Magnetresonanz
- Naturwissenschaften Chemie Physikalische Chemie Molekulare Chemische Nanostrukturen
- Technische Wissenschaften Sonstige Technologien | Angewandte Technik Medizintechnik, Biomedizintechnik
- Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizin, Gesundheitswesen Medizintechnik, Biomedizintechnik, Medizinische Werkstoffe
Weitere Infos & Material
Introduction.- Multifunctional GNS nanoprobe development and characterization.- In vivo evaluation of GNS nanoprobe.- GNS toxicity investigation.- Sensitive brain tumor detection using GNS nanoprobe.- Photoimmunotherapy for cancer metastasis treatment.- Conclusion and future outlook.