Inorganic and Organometallic Transition Metal Complexes with Biological Molecules and Living Cells

Erscheinungsjahr 2017
ISBN: 978-0-12-803814-7
Verlag: Elsevier Inc

Buch, Englisch, 406 Seiten, Format (B × H): 152 mm x 229 mm, Gewicht: 545 g

Inorganic and Organometallic Transition Metal Complexes with Biological Molecules and Living Cells provides a complete overview of this important research area that is perfect for both newcomers and expert researchers in the field. Through concise chapters written and edited by esteemed experts, this book brings together a comprehensive treatment of the area previously only available through scattered, lengthy review articles in the literature. Advanced topics of research are covered, with particular focus on recent advances in the biological applications of transition metal complexes, including inorganic medicine, enzyme inhibitors, antiparasital agents, and biological imaging reagents.

Zielgruppe

<p>Inorganic chemistry, medicinal chemistry, and drug development researchers; secondarily advanced chemistry and biology students</p>

Autoren/Hrsg.

Lo, Kenneth Kam-Wing

Fachgebiete

• Naturwissenschaften Biowissenschaften Molekularbiologie
• Naturwissenschaften Chemie Organische Chemie Organometallchemie
• Naturwissenschaften Chemie Anorganische Chemie
• Naturwissenschaften Biowissenschaften Zellbiologie

Inhaltsverzeichnis

1. Luminescent Zinc Complexes as Bioprobes for Imaging Molecular Events in Live Cells 2. Cellular Uptake and Sensing Capability of Transition Metal Peptide Conjugates 3. Luminescent Rhenium(I) and Iridium(III) Complexes for Intracellular Labeling, Sensing, and Photodynamic Therapy Applications 4. Organoruthenium(II)-Arene Complexes: Structural Building Blocks for Anticancer Drug Discovery 5. Medicinal Chemistry of Metal N-Heterocyclic Carbene (NHC) Complexes 6. Metal Complexes as Delivery Systems for CO, NO, and H2S to Explore the Signaling Network of Small-Molecule Messengers 7. Antimicrobial Metallodrugs 8. Carbon Nanotubes and Related Nanohybrids Incorporating Inorganic Transition Metal Compounds and Radioactive Species as Synthetic Scaffolds for Nanomedicine Design 9. Immobilized Metal Affinity Chromatography (IMAC) for Metalloproteomics and Phosphoproteomics 10. The Analysis of Therapeutic Metal Complexes and Their Biomolecular Interactions

Über Autor(innen)

Lo, Kenneth Kam-Wing
Kenneth Lo is a Chair Professor of Inorganic Chemistry at City University of Hong Kong, specializing in luminescent inorganic and organometallic transition metal complexes for biomolecular and cellular applications. His research includes developing intracellular sensors, photoactive labels, bioimaging reagents, and photocytotoxic agents. He has received prestigious awards, including the APA Prize for Young Scientist (2005), the Distinguished Lectureship Award from the Chemical Society of Japan (2011), the Hans Freeman Lectureship from the University of Sydney (2024), and the Elsevier Lectureship Award from the Japanese Photochemistry Association (2025). He was awarded a Croucher Senior Research Fellowship (2015) and became a Fellow of the Royal Society of Chemistry (2018). Professor Lo chaired the Gordon Research Conference on Metals in Medicine (2018) and the 23rd International Symposium on Photochemistry and Photophysics of Coordination Compounds (2019). Since 2020, he has served as an Associate Editor for the ACS journal Inorganic Chemistry.