Development and Application of Biomarkers

1. Auflage 2010
ISBN: 978-1-4398-1979-1
Verlag: CRC Press

Buch, Englisch, 297 Seiten, Format (B × H): 161 mm x 240 mm, Gewicht: 614 g

Reihe: Protein Science

First introduced to biomedical research in 1980, the term biomarker has taken on a life of its own in recent years and has come to mean a number of things. A comprehensive assessment of biomarkers, this book covers the history and current status of the application of biomarkers in diagnostics and prognostics. It explores the technology used for the study of biomarkers, and the validation of biomarkers including a comparison of the various technologies used to identify and measure biomarkers. The editors emphasize the technology underlying biomarkers and the translation of basic science to clinical laboratory technology, including the commercial development of biomarkers. The book also covers proteomics and proteomic technologies and their applications in the identification of biomarkers.

Zielgruppe

Academic and Postgraduate

Autoren/Hrsg.

Lundblad, Roger L.

Fachgebiete

• Technische Wissenschaften Verfahrenstechnik | Chemieingenieurwesen | Biotechnologie Biotechnologie
• Naturwissenschaften Biowissenschaften Molekularbiologie
• Naturwissenschaften Biowissenschaften Proteinforschung

Inhaltsverzeichnis

History of Biomarkers. Application of Biomarkers in Diagnostics and Theranostics. The Use of Proteomics to Identify Biomarkers. Carbohydrate and Polysaccharide Biomarkers. Complex Biomarkers. Analytical Technologies Used in Biomarker Research. Microarrays and Biomarkers. Use of Solid Phase lmmunoassays for Biomarker Research. Validation Issues in Development and Application of Biomarkers. Comparison of Technologies Used to Identify Biomarkers. Glossary. References.

Über Autor(innen)

Roger L. Lundblad is a highly accomplished expert in protein science and proteomics. He is well known for the rigorous application of classical protein science to more modern approaches and the development of a wealth of viable and practical applications. Dr. Lundblad is a native of San Francisco, California. He received his undergraduate education at Pacific Lutheran University and his Ph.D. degree in biochemistry at the University of Washington. After post-doctoral work in the laboratories of Stanford Moore and William Stein at the Rockefeller University, he joined the faculty of the University of North Carolina at Chapel Hill in 1968 attaining the rank of Full Professor in 1976 He joined the Hyland Division of Baxter Healthcare in 1990.

Currently Dr. Lundblad is an independent consultant and writer in biotechnology in Chapel Hill, North Carolina. He is an adjunct Professor of Pathology at the University of North Carolina at Chapel Hill and Editor-in-Chief of the Internet Journal of Genomics and Proteomics. He has authored and edited numerous books that focus both on advances in proteomics and modern applications as well as on the fundamentals of protein science. He recently co-edited Handbook of Biochemistry and Molecular Biology, Fourth Edition.