Gene Action

A Historical Account
Erscheinungsjahr 2000
ISBN: 978-0-19-514131-3
Verlag: Oxford University Press

Buch, Englisch, 176 Seiten, Format (B × H): 161 mm x 240 mm, Gewicht: 435 g

As a college student, Werner Maas took a course in genetics in 1941 and wondered why so little was said about the biochemical action of genes in controlling the specific function of an organism. Just at that time, biochemists and geneticists began to investigate jointly the basis of gene action, especially in microorganisms. Thus, Maas was able to witness firsthand the spectacular developments that led in the next twenty-five years to a clear picture of the action of genes. The history of these remarkable discoveries is the core of this book.

After 1965, building on insights gained from the work with microorganisms, studies of gene action turned to animals and plants and concentrated on processes not present in microorganisms, such as embryonic development, the role of genes in diseases, and the function of the nervous system. Because of the rapidity of technical advances made in handling genes, it has been possible to learn much about these complex processes. The last part of the book deals with these developments, which are ongoing parts of the history of gene action.

Autoren/Hrsg.

Maas, Werner

Fachgebiete

• Naturwissenschaften Biowissenschaften Tierkunde / Zoologie Tiergenetik, Reproduktion
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Vorklinische Medizin: Grundlagenfächer Humangenetik
• Naturwissenschaften Biowissenschaften Biowissenschaften DNA und Transgene Organismen
• Naturwissenschaften Biowissenschaften Biowissenschaften Genetik und Genomik (nichtmedizinisch)
• Naturwissenschaften Biowissenschaften Botanik Pflanzenreproduktion, Verbreitung, Genetik

Inhaltsverzeichnis

- Preface

- Part I: The Classical Period, 1860-1940

- Prelude

- 1: Overture: The Garden of Mendel

- 2: Building a Scaffold: Genes Within Chromosomes

- Part II: One Gene-One Enzyme, 1900-1953

- Prelude

- 3: The Dawn of the One Gene-One Enzyme Hypothesis during the Classical Period

- 4: The Neurospora Era

- 5: E. coli Enters the Field

- 6: Biochemical Genetics in E. coli

- 7: The Chemical Nature of Genes

- Part III: How Genes Determine Protein Structure

- Prelude

- 8: Building a Theoretical Framework for Gene Action

- 9: Biochemical Identification of Adaptors

- 10: The Elusive Messenger

- 11: Deciphering the Code

- Part IV: Regulation of Gene Action

- Prelude

- 12: Feedback Control of Biosynthetic Pathways

- 13: Adaptive Enzymes

- 14: The Operon Model

- Part V: The Aftermath of the Operon Model

- Prelude

-

- Appendix/Further Readings