Directed C-H Bond Functionalization

Concepts and Applications
1. Auflage 2025
ISBN: 978-3-527-35419-1
Verlag: WILEY-VCH

Buch, Englisch, 576 Seiten, Format (B × H): 170 mm x 244 mm, Gewicht: 680 g

Streamlined, cost-effective, and environmentally benign concepts for the synthesis of chemical building blocks and pharmaceuticals

Directed C—H Bond Functionalization summarizes recent advances in the field of selective and efficient C—H bond functionalization using directing groups.

Written by a team of experts in the field, Directed C—H Bond Functionalization includes information on: - History of the C—H bond activation and its discovery
- In-built functional group-directed C—H functionalization, proximal C—H bond functionalization, and template-assisted distal C—H bond functionalization
- Transient-directing group-assisted C—H bond functionalization and bifunctional non-covalent template-assisted C—H functionalization
- Redox catalytic methods and metal-free directed C—H functionalization reactions
- Industrial and synthetic application of directed C—H bond functionalization in organic synthesis, medicinal, and process chemistry

With its all-encompassing approach, Directed C—H Bond Functionalization is a timely, essential reference for synthetic chemists in academia and industry working in the fields of organic synthesis, catalysis, sustainable chemistry, and drug design.

Autoren/Hrsg.

Maiti, Debabrata

Rej, Supriya

Fachgebiete

• Technische Wissenschaften Verfahrenstechnik | Chemieingenieurwesen | Biotechnologie Verfahrenstechnik, Chemieingenieurwesen
• Naturwissenschaften Chemie Organische Chemie
• Naturwissenschaften Chemie Physikalische Chemie Chemische Reaktionen, Katalyse

Inhaltsverzeichnis

Preface
1. History of Directed C-H Bond Activation and its Discovery
2. Pd-Catalyzed In-Built Functional Group-Directed C-H Functionalization
3. Traceless Directing Group in C-H Bond Functionalization
4. Removable Directing Group in Proximal C-H Functionalization
5. Removable Template-assisted Transition Metal-catalyzed Distal C-H Functionalization
6. Non-covalent Template-assisted C-H Bond Functionalization
7. Pd/norbornene (NBE) Cooperative Catalysis in C-H Bond Activation
8. Transient Directing Groups in C-H Bond Functionalization
9. Redox Catalysis in Directed C-H Functionalization
10. Emerging Metal-free Directed C-H Functionalization
11. Directed C(sp3)-H Functionalization in Asymmetric Synthesis
12. Photochemical Activations of C(sp3)-H Bonds
13. Dual Transition Metal/Photoredox Catalysis for Directed C(sp2)-H Activations
14. Industrial and Flow Application of Directed C-H Bond Functionalization
15. Applications of Directed C-H Functionalization in Medicinal and Process Chemistry

Über Autor(innen)

Debabrata Maiti is Professor and Institute Chair in the Department of Chemistry, IIT Bombay, India. He received his PhD from John Hopkins University (USA) in 2008 under the supervision of Prof. Kenneth D. Karlin. After postdoctoral studies at the Massachusetts Institute of Technology with Prof. Stephen L. Buchwald (2008-2010), he joined the Department of Chemistry at IIT Bombay in 2011. He has authored about 150 scientific publications and received numerous scientific awards. His research interests are focused on the development of new and sustainable synthetic and catalytic methodologies. He is an Associate Editor for the Journal of Organic Chemistry (ACS).
 
Supriya Rej is a Ramanujan faculty in the Department of Chemistry at IIT Dharwad, India. He received his PhD from Osaka University (Japan) in 2017 under the supervision of Prof. Kazushi Mashima and then joined Prof. Naoto Chatani's research group at the same university as a postdoctoral research associate. He was appointed as an Assistant Professor at Osaka University in 2020. He was awarded an Alexander von Humboldt postdoctoral fellowship and in 2021 joined TU Berlin (Germany) as a postdoctoral researcher with Prof. Martin Oestreich. He then became an assistant professor at Christ University in Bangalore, India, and a lecturer at the Centre of BioMedical Research (CBMR) in Lucknow, India. His current research focuses on bond activation and synthetic methodology development.