Buch, Englisch, 570 Seiten, Format (B × H): 178 mm x 254 mm
Reihe: Methods in Molecular Biology
Buch, Englisch, 570 Seiten, Format (B × H): 178 mm x 254 mm
Reihe: Methods in Molecular Biology
ISBN: 978-1-0716-5582-5
Verlag: Springer Us
This fully updated edition explores recent techniques involving computational approaches to the study of synthetic biology. Covering genetic circuit design, analysis, and optimization like the previous editions, this book focuses on protein language models, machine learning and deep learning approaches, larger-scale systems, such as metabolic networks, RNA structure prediction, as well as emerging AI-based methods. Written for the series, chapters include the kind of detailed instruction and expert implementation advice that encourages success in the pursuit of further experimentation.
Authoritative and up-to-date, serves as an ideal guide for researchers searching for improved solutions to long-standing design and modeling challenges and support for the analysis and engineering of increasingly complex biological systems.
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Weitere Infos & Material
Fine-Tuning a Protein Language Model for an Epitope Library Generation and Sequence Filtering.- Employing Protein Language Models to Predict TCR-Peptide-MHC Binding: A Comprehensive Methods Guide.- Promoter Prediction in Helicobacter pylori Strain 26695 by Using a Deep Neural Network.- Computational Design of Prokaryotic Translation Regulation Based on RNA-Binding Proteins.- Design Space Exploration of Genetic Circuits Using the UNFOLD Framework.- Synthetic Gene Circuit Analysis and Optimization.- Construction of an Enzyme-Constrained Model for Escherichia coli Using GECKO Toolbox 3.0.- Genome-Scale Metabolic Modeling of Escherichia coli and Its Chassis Design for Synthetic Biology Applications.- Data-Driven Mechanistic Modeling of Untargeted Metabolome Data.- Quantifying Turnover in Resource Economy of Synthetic Biology Applications via Stochastic Simulations.- Flexible RNA Design with Partial Constraints.- Meta-Scoring Approach to Curate Synthetic RNA 3D Structures.- RNA Tertiary Structure Prediction and Analysis Using NuFold and the NuFold Database.- Array Assembler: A Constraint-Aware Pipeline for Cas12 and Cas13 crRNA Array Design and Oligonucleotide Decomposition.- IVA Prime: Automatic Primer Design for In Vivo DNA Assembly.- Computer-Driven Construction of a Saccharomyces cerevisiae Aromatase Inhibitor Screening Platform.- Automated Replicative Lifespan Determination in Diploid Yeast Using a Microfluidic Chip and ResNet-Based Image Analysis.- Protocol for Model-Based Response-Corrected Fluorescence Quantification with Low-Cost Spectral Sensors.- Metrics for the Evaluation of 3D Segmentation in Biomolecules.- An Integrated Ecosystem for Analysis and Visualization of Large-Scale Phylogenomic Data Combining ETE Toolkit, TreeProfiler, and PhyloCloud for Scalable Phylogenomic Analysis.
