Factors Affecting Neurodevelopment

Genetics, Neurology, Behavior, and Diet
Erscheinungsjahr 2021
ISBN: 978-0-12-817986-4
Verlag: Elsevier Science

Buch, Englisch, 684 Seiten, Format (B × H): 218 mm x 282 mm, Gewicht: 2087 g

Factors Affecting Neurodevelopment: Genetics, Neurology, Behavior, and Diet is a comprehensive reference on the genetic and behavioral features associated with proper and abnormal development. The book discusses the mechanisms underlying neurological development and provides readers with a detailed introduction to the neural connections and complexities in biological circuitries, as well as the physiological, behavioral, molecular, and cellular features of neurodevelopment. In addition, the book examines in vitro and in vivo modeling of development with stem cells and model systems.

Autoren/Hrsg.

Martin, Colin R.

Preedy, Victor R.

Rajendram, Rajkumar

Fachgebiete

• Sozialwissenschaften Psychologie Allgemeine Psychologie Entwicklungspsychologie Kinder- und Jugendpsychologie
• Sozialwissenschaften Psychologie Allgemeine Psychologie Biologische Psychologie, Neuropsychologie
• Interdisziplinäres Wissenschaften Wissenschaften Interdisziplinär Neurowissenschaften, Kognitionswissenschaft
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Neurologie, Klinische Neurowissenschaft

Inhaltsverzeichnis

I. Genetics, Molecular and Celluar Biology
1. Hereditary motor neuropathies
2. Dopamine transporter (DAT1) polymorphism and development
3. Genome wide association studies (GWAS) and neurodevelopment: Autism spectrum disorder
4. SNPs and cerebral palsy
5. Epigenetic regulation of cortical neurogenesis
6. Functions and dynamics of axonal mitochondria
7. Linking apoptosis and caspases in fetal neural tube defects
8. Brain oxidative stress in Down syndrome
9. Linking Adhesion GPCRs to Glial Cell Development and Function
10. Immunoglobulin cell adhesion molecule superfamily and neurodevelopment
11. Brain-derived neurotrophic factor (BDNF) and neurogenesis
12. slc7a5 and neural development
13. Linking SOX3, SRY and disorders of neurodevelopment
14. Neuronal Src-homology-2 (SH2)B adaptor protein-1 (Sh2b1) and brain growth
15. Effects of extrinsic factors and intracellular signalling and transcription factors regulating the development and cell fate of spinal cord ependymal cells
16. Signaling molecules controlling oligodendrocyte development and brain myelination

II. Neurological and Imaging Features
17. Fetal brain structures: imaging oriented
18. Four-dimensional (4D) ultrasonography: Methods, uses and fetal neuroscience
19. Linking histology and neurological development of the fetal and infant brain
20. Development of Corticospinal tract axons: from embryonic stage to adulthood
21. Vascular endothelial growth factor (VEGF) and neurodevelopment
22. Brain-wide connectivity architecture: developmental aspects
23. Development and pathology of the germinal matrix
24. Development of the GABAergic network in the mouse spinal cord
25. Postnatal development, electrophysiology and sensory sural nerves
26. Neuroscience of the developing axonal strata in the human fetal brain
27. Neuroactive steroids and neurodevelopment
28. Voltage and ligand-gated ion channels appearance and function in neurodevelopment
29. Features of brain development over 13 years in preterms
30. The medial pulvinar in neurodevelopment
31. Cortical sulci in the human fetal brain and development
32. The prenatal development of the human cerebellum
33. Developing cerebello-cerebral connectivity in health and disease: a focus on epilepsy
34. Prenatal exposure to progestins: impact on neurodevelopment of the child

III. Physiological Aspects
35. Brain lesion characteristics in relation to upper limb function in children with unilateral cerebral palsy
36. Maternal exercise and brain development
37. Pyramidal neurons: physiology, Pathophysiology and postnatal development
38. Working memory: physiology and neurodevelopment
39. EEG development in resting states
40. Availability and metabolism of thyroid hormones in the developing brain

IV. Behavior and Psychopathological Aspects
41. Psychosocial issues and quality of life following childhood stroke
42. Neuropsychological function following childhood stroke
43. Youths with autism and working memory
44. Linking the mesial temporal lobe, 3D probabilistic maps and development
45. Cognitive aspects of Down Syndrome
46. Adolescent cannabis use and neurocognitive development
47. The Role of Social Anxiety in Autism and the Broader Autism Phenotype: Evidence from Childhood through Adulthood
48. Impact of touch on bonding and neurodevelopment
49. Neurobehaviour and catch up growth

V. Diet and Nutrition
50. Caloric restriction and the developing brain
51. High-fat diet, tryptophan hydroxylase-2 mRNA expression and neurodevelopment

52. Bone mineral density and nutritional status in children with cerebral palsy
53. Epigallocatechin-3-gallate: Linking the neurogenesis, hippocampus and Down syndrome
54. Folic acid-to prevent spina bifida and anencephaly

Über Autor(innen)

Rajendram, Rajkumar
Dr Rajkumar Rajendram is a clinician-scientist with expertise in internal medicine, anaesthesia, intensive care and peri-operative medicine. He graduated with distinctions from Guy’s, King’s and St Thomas’ Medical School, King’s College London, in 2001, where he received several prizes, merits and distinctions in pre-clinical and clinical subjects.

Dr Rajendram completed specialist training in acute and general medicine in Oxford and subsequently held a Consultant appointment in Acute General Medicine at the John Radcliffe Hospital, Oxford. He also trained in anaesthesia and intensive care in London, including advanced training in regional anaesthesia and intensive care, and subsequently held a Consultant appointment in Intensive Care, Anaesthesia and Peri-operative Medicine at the Royal Free London Hospitals.

His postgraduate training has spanned internal medicine, anaesthesia, intensive care and point-of-care ultrasound (POCUS). He was awarded Fellowship of the Royal College of Anaesthetists in 2009, Fellowship of the Faculty of Intensive Care Medicine in 2013, and the European Diploma in Intensive Care Medicine in 2014. He is a Fellow of both the Royal College of Physicians of Edinburgh and the Royal College of Physicians of London.

Dr Rajendram is currently a Consultant at King Abdulaziz Medical City, Ministry of National Guard Health Affairs, Riyadh, Saudi Arabia, and holds a joint appointment as Associate Professor in the Research Unit, Department of Medical Education, at King Saud bin Abdulaziz University for Health Sciences.

His multidisciplinary clinical background has informed his research interests in nutrition, fluid management and fluid balance in health and disease, particularly in acutely and critically ill patients. His research has also addressed POCUS, COVID-19 phenotypes and nutritional support in illness. Dr Rajendram has contributed extensively to medical research and education and has authored more than 400 textbook chapters, review articles, peer-reviewed papers and conference abstracts.

Preedy, Victor R.
Victor R. Preedy, BSc, PhD, DSc, FRSB, FRSPH, FRCPath, FRSC, FRSM, is Professor of Clinical Biochemistry (Hon) at King’s College Hospital and Emeritus Professor of Nutritional Biochemistry at King’s College London. He also holds an Honorary Professorship at the University of Suffolk and served as the long-term Director of the Genomics Centre at King’s College London from 2006 to 2020. Professor Preedy graduated with an Honours Degree in Biology and Physiology with Pharmacology and later obtained his PhD from the University of London. He subsequently received Membership of the Royal College of Pathologists and later earned his second doctorate (DSc) in recognition of his contributions to protein metabolism. He is a Fellow of the Royal Society of Medicine, the Royal Society of Biology, the Royal College of Pathologists, the Royal Society for the Promotion of Health, the Royal Institute of Public Health and Hygiene, the Royal Society for Public Health, and the Royal Society of Chemistry. Professor Preedy has conducted research while affiliated with Imperial College London, the School of Pharmacy (now part of University College London), and the MRC Centre at Northwick Park Hospital. He has collaborated widely with international research groups in Finland, Japan, Australia, the USA, and Germany. His longstanding academic interests include health and well-being. He has published more than 750 works, including peer-reviewed research articles, abstracts, symposium presentations, reviews, and edited books.

Martin, Colin R.
Colin R. Martin RN, BSc, MSc, PhD, MBA, YCAP, FHEA, C.Psychol, AFBPsS, C.Sci is Professor of Clinical Psychobiology and Applied Psychoneuroimmunology and Clinical Director of the Institute of Health and Wellbeing at the University of Suffolk, UK. He is a Chartered Health Psychologist and a Chartered Scientist. He also trained in analytical biochemistry, this aspect reflecting the psychobiological focus of much of his research within mental health. He has published or has in press well over 300 research papers and book chapters. He is a keen book author and editor having written and/or edited more than 50 books. These outputs include the prophetic insight into the treatment of neurological disease, Handbook of Behavior, Food and Nutrition (2011), Nanomedicine and the Nervous System (2012), Oxidative Stress and Dietary Antioxidants in Neurological Disease (2020), Zika Virus Impact, Diagnosis, Control and Models (2021), Factors Affecting Neurodevelopment: Genetics, Neurology, Behavior and Diet (2021), Diagnosis and Treatment of Spinal Cord Injury (2022), The Neurobiology, Physiology, and Psychology of Pain (2022) and The Handbook of Lifespan Cognitive Behavioral Therapy: Childhood, Adolescence, Pregnancy, Adulthood, and Aging (2023). Professor Martin is particularly interested in all aspects of the relationship between underlying physiological substrates and behavior, particularly in how these relationships manifest in both acute and chronic psychiatric disorder. He has published original research germane to significant mental health disorders including the areas of schizophrenia, anxiety, depression, self-esteem, alcohol and drug dependency, high secure forensic mental health and personality disorder. He has a keen interest in the impact of postviral illness and is actively involved in clinical research post-Covid pandemic and in particular, the impact of Long Covid on psychological, neurological, physiological and social functioning. He is involved in collaborative International research with many European and Non-European countries.