Factors Affecting Neurological Aging

Genetics, Neurology, Behavior, and Diet
Erscheinungsjahr 2021
ISBN: 978-0-12-817990-1
Verlag: Elsevier Science

Buch, Englisch, 686 Seiten, Format (B × H): 221 mm x 284 mm, Gewicht: 2064 g

Factors Affecting Neurological Aging: Genetics, Neurology, Behavior, and Diet is a comprehensive reference on the genetic and behavioral features associated with neurological aging and associated disorders. This book discusses the mechanisms underlying neurological aging and provides readers with a detailed introduction to the aging of neural connections and complexities in biological circuitries, as well as the physiological, behavioral, molecular, and cellular features of neurological aging. Finally, this comprehensive resource examines the use of animal modeling of aging and neurological disease.

Autoren/Hrsg.

Martin, Colin R.

Preedy, Victor R.

Rajendram, Rajkumar

Fachgebiete

• Interdisziplinäres Wissenschaften Wissenschaften Interdisziplinär Neurowissenschaften, Kognitionswissenschaft
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Neurologie, Klinische Neurowissenschaft
• Sozialwissenschaften Psychologie Allgemeine Psychologie Biologische Psychologie, Neuropsychologie
• Sozialwissenschaften Psychologie Allgemeine Psychologie Entwicklungspsychologie Kinder- und Jugendpsychologie

Inhaltsverzeichnis

I. Genetics, Molecular and Cellular Biology1. Genetics of frontotemporal dementia2. Aging, brain-derived neurotrophic factor (BDNF) and its polymorphism3. Aging, demented patients, and polymorphisms in cytokine genes4. RNA fragments and brain aging5. Centrosome functions and remodeling during neuronal development and centrosome abnormalities in neuronal disorders, disease, and in aging6. Brain aging and microarray analysis7. Human nuclear tau and aging8. Lipoxidation: features, neurological tissues and aging9. Aging and brain amino acids10. How 3’,5’-cyclic nucleotide phosphodiesterases change in the brain with normal aging and dementia11. The prohibitin complex in aging and neurodegeneration12. Synaptic ATPase and energy metabolism in the nervous system: roles and changes in the aging process

II. Neurological and Imaging Features13. Microstructural Imaging of the Human Brain with Normal and "Abnormal" Aging using Diffusion Magnetic Resonance Imaging14. Imaging the brain and its vascular in aging: Applications of optical coherence tomography angiography15. Potential involvement of perineuronal nets in brain aging: an anatomical point of view16. Grey-matter networks in aging17. Brain synapse-related proteins what they do and how they change in aging18. Macro- and chaperone-mediated autophagy in aging19. Neuronal L-type calcium channels in aging20. D-serine-regulated glutamatergic transmission and microglia: impact of aging21. Voltage-gated potassium channels and the aging brain22. Dendritic spine remodeling and aging23. High-density lipoprotein-cholesterol and neuroaging: memory, gyrification of the insular and frontal opercular cortex24. Astrocyte and microglial aging: morphology and modelling25. Neural scaffolding: features, profiles and the aging cerebellum26. BACE1 RNAi, memory and aging27. Aging, myelination and the optic nerve28. Linking proteostasis, brain aging, and ischemia29. Luteinizing hormone and the aging nervous system30. Insights into aging using transcranial magnetic stimulation31. Alpha rhythms: what they are and how they alter with aging32. Nicotine and its derivatives in healthy brain aging

III. Physiological Aspects33. Environmental enrichment and physiological aging34. Treadmill exercise and neuroinflammation: links with aging35. Impact of aerobic exercise on brain structure in models of aging: hippocampus and beyond36. The physiology of fitness and the brain in aging37. Aging, Babble Noise and the processing of speech perception38. The blood-brain barrier in aging

IV. Behavior And Psychopathological Aspects39. Linking aging, anticholinergic drug use, and cognitive impairment40. Cognitive Frailty: Definition, components and impact on disability, and mortality41. The physiology of the "Brain-muscle loop" in aging42. Disentangling the effects of aging and ovarian hormone loss on sleep: Implications for health and disease43. Role of DNA methylation in aging-related cognitive functioning'44. Depression in the elderly and psychobiotics

V. Diet And Nutrition45. Aging, dietary patterns and cognition46. Geriatric nutritional risk index: Application, and limitations47. Diet, inflammatory biomarkers, and brain aging48. DASH diet and brain aging49. The ketogenic diet and healthy brain aging50. Autophagy and aging: diet, exercise, and the link with the target of rapamycin complex 1 (TORC)51. Dietary Flavonoids and Brain Health in Ageing: food for Thought52. Antioxidant effects of curcumin and neuroaging53. Lipoic acid and vitamin D3 and their use in preventing brain aging54. Aging and working memory: Impact of the leucine metabolite beta hydroxy-beta-methyl butyrate55. Hydration, the brain and aging

Über Autor(innen)

Rajendram, Rajkumar
Dr Rajkumar Rajendram is a clinician-scientist with expertise in internal medicine, anaesthesia, intensive care and peri-operative medicine. He graduated with distinctions from Guy’s, King’s and St Thomas’ Medical School, King’s College London, in 2001, where he received several prizes, merits and distinctions in pre-clinical and clinical subjects.

Dr Rajendram completed specialist training in acute and general medicine in Oxford and subsequently held a Consultant appointment in Acute General Medicine at the John Radcliffe Hospital, Oxford. He also trained in anaesthesia and intensive care in London, including advanced training in regional anaesthesia and intensive care, and subsequently held a Consultant appointment in Intensive Care, Anaesthesia and Peri-operative Medicine at the Royal Free London Hospitals.

His postgraduate training has spanned internal medicine, anaesthesia, intensive care and point-of-care ultrasound (POCUS). He was awarded Fellowship of the Royal College of Anaesthetists in 2009, Fellowship of the Faculty of Intensive Care Medicine in 2013, and the European Diploma in Intensive Care Medicine in 2014. He is a Fellow of both the Royal College of Physicians of Edinburgh and the Royal College of Physicians of London.

Dr Rajendram is currently a Consultant at King Abdulaziz Medical City, Ministry of National Guard Health Affairs, Riyadh, Saudi Arabia, and holds a joint appointment as Associate Professor in the Research Unit, Department of Medical Education, at King Saud bin Abdulaziz University for Health Sciences.

His multidisciplinary clinical background has informed his research interests in nutrition, fluid management and fluid balance in health and disease, particularly in acutely and critically ill patients. His research has also addressed POCUS, COVID-19 phenotypes and nutritional support in illness. Dr Rajendram has contributed extensively to medical research and education and has authored more than 400 textbook chapters, review articles, peer-reviewed papers and conference abstracts.

Martin, Colin R.
Colin R. Martin RN, BSc, MSc, PhD, MBA, YCAP, FHEA, C.Psychol, AFBPsS, C.Sci is Professor of Clinical Psychobiology and Applied Psychoneuroimmunology and Clinical Director of the Institute of Health and Wellbeing at the University of Suffolk, UK. He is a Chartered Health Psychologist and a Chartered Scientist. He also trained in analytical biochemistry, this aspect reflecting the psychobiological focus of much of his research within mental health. He has published or has in press well over 300 research papers and book chapters. He is a keen book author and editor having written and/or edited more than 50 books. These outputs include the prophetic insight into the treatment of neurological disease, Handbook of Behavior, Food and Nutrition (2011), Nanomedicine and the Nervous System (2012), Oxidative Stress and Dietary Antioxidants in Neurological Disease (2020), Zika Virus Impact, Diagnosis, Control and Models (2021), Factors Affecting Neurodevelopment: Genetics, Neurology, Behavior and Diet (2021), Diagnosis and Treatment of Spinal Cord Injury (2022), The Neurobiology, Physiology, and Psychology of Pain (2022) and The Handbook of Lifespan Cognitive Behavioral Therapy: Childhood, Adolescence, Pregnancy, Adulthood, and Aging (2023). Professor Martin is particularly interested in all aspects of the relationship between underlying physiological substrates and behavior, particularly in how these relationships manifest in both acute and chronic psychiatric disorder. He has published original research germane to significant mental health disorders including the areas of schizophrenia, anxiety, depression, self-esteem, alcohol and drug dependency, high secure forensic mental health and personality disorder. He has a keen interest in the impact of postviral illness and is actively involved in clinical research post-Covid pandemic and in particular, the impact of Long Covid on psychological, neurological, physiological and social functioning. He is involved in collaborative International research with many European and Non-European countries.

Preedy, Victor R.
Victor R. Preedy, BSc, PhD, DSc, FRSB, FRSPH, FRCPath, FRSC, FRSM, is Professor of Clinical Biochemistry (Hon) at King’s College Hospital and Emeritus Professor of Nutritional Biochemistry at King’s College London. He also holds an Honorary Professorship at the University of Suffolk and served as the long-term Director of the Genomics Centre at King’s College London from 2006 to 2020. Professor Preedy graduated with an Honours Degree in Biology and Physiology with Pharmacology and later obtained his PhD from the University of London. He subsequently received Membership of the Royal College of Pathologists and later earned his second doctorate (DSc) in recognition of his contributions to protein metabolism. He is a Fellow of the Royal Society of Medicine, the Royal Society of Biology, the Royal College of Pathologists, the Royal Society for the Promotion of Health, the Royal Institute of Public Health and Hygiene, the Royal Society for Public Health, and the Royal Society of Chemistry. Professor Preedy has conducted research while affiliated with Imperial College London, the School of Pharmacy (now part of University College London), and the MRC Centre at Northwick Park Hospital. He has collaborated widely with international research groups in Finland, Japan, Australia, the USA, and Germany. His longstanding academic interests include health and well-being. He has published more than 750 works, including peer-reviewed research articles, abstracts, symposium presentations, reviews, and edited books.