Computational Physiology

Simula Summer School 2024/2025 - Student Reports
Erscheinungsjahr 2026
ISBN: 978-3-032-28825-7
Verlag: Springer

Buch, Englisch, Band 20, 128 Seiten, Format (B × H): 155 mm x 235 mm, Gewicht: 257 g

Reihe: Simula SpringerBriefs on Computing

In this open access volume, interested readers will find a number of modern approaches to modeling excitable tissue applied to current open research questions in the field via student reports from the 2024 and 2025 Simula Summer School in Computational Physiology (SSCP). 

SSCP is co-hosted by Simula, the University of Oslo (UiO), and UCSD. The course focuses on modeling excitable tissues. Masters and PhD students conduct group research projects, and each group produces a report addressing a specific problem of importance in physiology. Reports may not necessarily represent new scientific results; rather, they can reproduce or supplement earlier computational or experimental studies. 

Reports from eight of the summer projects are included as separate chapters. The fields represented include cardiac electrophysiology (Chapters 1-3), pancreatic beta-cell electrophysiology (Chapters 4-5), subcellular cardiac calcium handling (Chapter 6), cardiac mechanics (Chapter 7), and biology-inspired AI (Chapter 8). 

Zielgruppe

Graduate

Autoren/Hrsg.

McCabe, Kimberly J.

Fachgebiete

• Interdisziplinäres Wissenschaften Wissenschaften Interdisziplinär Neurowissenschaften, Kognitionswissenschaft
• Mathematik | Informatik Mathematik Numerik und Wissenschaftliches Rechnen Numerische Mathematik
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Kardiologie, Angiologie, Phlebologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizin, Gesundheitswesen Medizintechnik, Biomedizintechnik, Medizinische Werkstoffe
• Technische Wissenschaften Maschinenbau | Werkstoffkunde Maschinenbau
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Pharmakologie, Toxikologie
• Technische Wissenschaften Sonstige Technologien | Angewandte Technik Medizintechnik, Biomedizintechnik

Inhaltsverzeichnis

Sex-Specific Effects of Doxorubicin on Cardiac Electromechanical Function: A Simulation-Based Study.- Biventricular Simulation Pipeline for Risk Stratification in Repaired Tetralogy of Fallot.- A Statistical Shape Modeling Pipeline for Assessing Arrhythmic Risk in Mitral Valve Disease Patients.- Differentiating the Roles of Metabolic Similarity and Ionic Coupling in Determining the Beta Hub Cell Phenotype.- Exploring the intrinsic and extrinsic determinants of heterogeneity in a -cell network.- Effects of cellular and subcellular geometry on store-operated calcium entry in dendritic spines.- Statistical Atlas-Based Surrogate Model of Biventricular Wall Mechanics.- Comparing the Hopfield Network and Sparse Distributed Memory Model in Pattern Completion.

Über Autor(innen)

Kimberly J. McCabe is a Senior Research Scientist at Simula Research Laboratory and the Programme Director for the Simula-UiO-UCSD Research PhD Training Programme (SUURPh). She holds a PhD in Bioengineering from the University of California, San Diego and her research focuses on subcellular modeling of cardiac mechanics and calcium handling.